Yoga is increasingly recognized for both its physical and mental health benefits, yet its central mechanisms of action remain unclear. In addition to benefits generally associated with physical exercise, yoga may also cultivate interoception, the sense of the body's internal state, the ability to notice and respond adaptively to physiological cues. Complicating matters, yoga training varies in the relative emphasis on physical movement and the cultivation of interoceptive awareness, yet few studies have explored whether differences in emphasis impact yoga's benefits. A randomized trial explored the effects of interoceptive emphasis in yoga training on attention and subjective wellbeing. Over a 10-week period featuring classes twice each week, community-dwelling adult participants with moderate depressive symptoms (N = 58) were randomized to attend either more Movement-Focused yoga or Interoception-Focused yoga. Assessments were conducted at baseline, post-intervention, and at a one-month follow-up, which included both self-reports of mood and interoception, and task-performance on a Sustained Attention to Response Task. Relative to Movement-Focused yoga, Interoception-Focused yoga practitioners showed greater improvements in sustained attention, but no differences in self-reported mood or interoception. Yet sustained attention improvements in the Interoception-Focused group were greatest for those endorsing high levels of interoception, an effect that was absent in the Movement-Focused group. Despite an exploratory sample size, these findings support the potential for an interoceptive focus to extend yoga's attentional benefits, particularly for those who report high interoceptive awareness.