Training Set Research Articles

Simple Method for Predicting the Heats of Formation of Energetic Metal–Organic Frameworks

Abstract The heats of formation (HOF) of energetic materials is crucial in determining their performance. A novel approach has been introduced to accurately predict the condensed phase HOF of energetic metal-organic frameworks (EMOFs). The experimental condensed phase HOF data of 63 EMOFs were utilized to develop and evaluate the model. This model relies on particular chemical bonds, elemental composition, and some of the specific structural parameters that can be obtained from the chemical structures of EMOFs. This model can be easily applied to EMOFs with intricate compositions and structures, without the need for complicated computer codes. Statistical parameters along with the internal and external validation approaches were employed to assess the accuracy, precision, goodness-of-fit, and goodness-of-prediction of the model. Values of the coefficients of determination in training set, as well as internal and external validation, i.e., R2, $${\text{Q}}_{{{\text{LOO}}}}^{2}$$, $${\text{Q}}_{{5{\text{-fold}}}}^{2}$$, and $$R_{{{\text{External}}}}^{2}$$ are 0.96, 0.93, 0.91, and 0.94, respectively.

Embodying Human-Like Modes of Balance Control Through Human-In-the-Loop Dyadic Learning

In this paper, we explore how humans and AIs trained to perform a virtual inverted pendulum (VIP) balancing task converge and differ in their learning and performance strategies. We create a visual analogue of disoriented IP balancing, as may be experienced by pilots suffering from spatial disorientation, and train AI models on data from human subjects performing a real-world disoriented balancing task. We then place the trained AI models in a dyadic human-in-the-loop (HITL) training setting. Episodes in which human subjects disagreed with AI actions were logged and used to fine-tune the AI model. Human subjects then performed the task while being given guidance from pretrained and dyadically fine-tuned versions of an AI model. We examine the effects of HITL training on AI performance, AI guidance on human performance, and the behavior patterns of human subjects and AI models during task performance. We find that in many cases, HITL training improves AI performance, AI guidance improves human performance, and after dyadic training the two converge on similar behavior patterns.

Verification of the MLP network-based current sensor fault classifier for vector-controlled AC motor drives

In modern drive systems, the aim is to ensure their operational safety. Damage can occur not only to the components of the motor itself but also to the power electronic devices included in the frequency converter and the sensors in the measurement circuit. Critical damage to the electric drive that makes its further exploitation impossible can be prevented by using fault-tolerant control (FTC) algorithms. These algorithms are very often combined with diagnostic methods that assess the degree and type of damage. In this paper, a fault classification algorithm using an artificial neural network (ANN) is analysed for stator phase current sensors in AC motor drives. The authors confirm that the investigated classification algorithm works equally well on two different AC motors without the need for significant modifications, such as retraining the neural network when transferring the algorithm to another object. The method uses a stator current estimator to replace faulty sensor measurements in a vector control structure. The measured and estimated currents are then subjected to a classification process using a multilayer perceptron (MLP), which has the advantage of a small structure size compared to deep learning structures. The uniqueness of the method lies in the use of data in the training set that are not dependent on the parameters of a specific motor. Four types of current sensor faults were studied, namely total signal loss, gain error, offset, and signal saturation. Simulations were performed in a MATLAB/SIMULINK environment for drive systems with an induction motor (IM) and a permanent magnet synchronous motor (PMSM). The results show that the algorithm correctly evaluates the type of damage in more than 99.6% of cases regardless of the type of motor. Therefore, the results presented here may help to develop universal diagnostic methods that will work on a wide variety of motors.

Distinguishing between aldosterone-producing adenomas and non-functional adrenocortical adenomas using the YOLOv5 network.

You Only Look Once version 5 (YOLOv5), a one-stage deep-learning (DL) algorithm for object detection and classification, offers high speed and accuracy for identifying targets. To investigate the feasibility of using the YOLOv5 algorithm to non-invasively distinguish between aldosterone-producing adenomas (APAs) and non-functional adrenocortical adenomas (NF-ACAs) on computed tomography (CT) images. A total of 235 patients who were diagnosed with ACAs between January 2011 and July 2022 were included in this study. Of the 215 patients, 81 (37.7%) had APAs and 134 (62.3%) had NF-ACAs' they were randomly divided into either the training set or the validation set at a ratio of 9:1. Another 20 patients, including 8 (40.0%) with APA and 12 (60.0%) with NF-ACA, were collected for the testing set. Five submodels (YOLOv5n, YOLOv5s, YOLOv5m, YOLOv5l, and YOLOv5x) of YOLOv5 were trained and evaluated on the datasets. In the testing set, the mAP_0.5 value for YOLOv5x (0.988) was higher than the values for YOLOv5n (0.969), YOLOv5s (0.965), YOLOv5m (0.974), and YOLOv5l (0.983). The mAP_0.5:0.95 value for YOLOv5x (0.711) was also higher than the values for YOLOv5n (0.587), YOLOv5s (0.674), YOLOv5m (0.671), and YOLOv5l (0.698) in the testing set. The inference speed of YOLOv5n was 2.4 ms in the testing set, which was the fastest among the five submodels. The YOLOv5 algorithm can accurately and efficiently distinguish between APAs and NF-ACAs on CT images, especially YOLOv5x has the best identification performance.

Deep Learning Method for Rapid Simultaneous Multistructure Temporal Bone Segmentation.

To develop and validate a deep learning algorithm for the automated segmentation of key temporal bone structures from clinical computed tomography (CT) data sets. Cross-sectional study. A total of 325 CT scans from a clinical database. A state-of-the-art deep learning (DL) algorithm (SwinUNETR) was used to train a prediction model for rapid segmentation of 9 key temporal bone structures in a data set of 325 clinical CTs. The data set was manually annotated by a specialist to serve as the ground truth. The data set was randomly split into training (n = 260) and testing (n = 65) sets. The model's performance was objectively assessed through external validation on the test set using metrics including Dice, Balanced accuracy, Hausdorff distances, and processing time. The model achieved an average Dice coefficient of 0.87 for all structures, an average balanced accuracy of 0.94, an average Hausdorff distance of 0.79 mm, and an average processing time of 9.1 seconds per CT. The present DL model for the automated simultaneous segmentation of multiple structures within the temporal bone from CTs achieved high accuracy according to currently commonly employed objective analysis. The results demonstrate the potential of the method to improve preoperative evaluation and intraoperative guidance in otologic surgery.

CLASSIFICATION OF KAZAKH MUSIC GENRES USING MACHINE LEARNING TECHNIQUES

This article analysis a Kazakh Music dataset, which consists of 800 audio tracks equally distributed across 5 different genres. The purpose of this research is to classify music genres by using machine learning algorithms Decision Tree Classifier and Logistic regression. Before the classification, the given data was pre-processed, missing or irrelevant data was removed. The given dataset was analyzed using a correlation matrix and data visualization to identify patterns. To reduce the dimension of the original dataset, the PCA method was used while maintaining variance. Several key studies aimed at analyzing and developing machine learning models applied to the classification of musical genres are reviewed. Cumulative explained variance was also plotted, which showed the maximum proportion (90%) of discrete values ​​generated from multiple individual samples taken along the Gaussian curve. A comparison of the decision tree model to a logistic regression showed that for f1 Score Logistic regression produced the best result for classical music - 82%, Decision tree classification - 75%. For other genres, the harmonic mean between precision and recall for the logistic regression model is equal to zero, which means that this model completely fails to classify the genres Zazz, Kazakh Rock, Kazakh hip hop, Kazakh pop music. Using the Decision tree classifier algorithm, the Zazz and Kazakh pop music genres were not recognized, but Kazakh Rock with an accuracy and completeness of 33%. Overall, the proposed model achieves an accuracy of 60% for the Decision Tree Classifier and 70% for the Logistic regression model on the training and validation sets. For uniform classification, the data were balanced and assessed using the cross-validation method. The approach used in this study may be useful in classifying different music genres based on audio data without relying on human listening.

An interpretable machine learning model for predicting 28-day mortality in patients with sepsis-associated liver injury.

Sepsis-Associated Liver Injury (SALI) is an independent risk factor for death from sepsis. The aim of this study was to develop an interpretable machine learning model for early prediction of 28-day mortality in patients with SALI. Data from the Medical Information Mart for Intensive Care (MIMIC-IV, v2.2, MIMIC-III, v1.4) were used in this study. The study cohort from MIMIC-IV was randomized to the training set (0.7) and the internal validation set (0.3), with MIMIC-III (2001 to 2008) as external validation. The features with more than 20% missing values were deleted and the remaining features were multiple interpolated. Lasso-CV that lasso linear model with iterative fitting along a regularization path in which the best model is selected by cross-validation was used to select important features for model development. Eight machine learning models including Random Forest (RF), Logistic Regression, Decision Tree, Extreme Gradient Boost (XGBoost), K Nearest Neighbor, Support Vector Machine, Generalized Linear Models in which the best model is selected by cross-validation (CV_glmnet), and Linear Discriminant Analysis (LDA) were developed. Shapley additive interpretation (SHAP) was used to improve the interpretability of the optimal model. At last, a total of 1043 patients were included, of whom 710 were from MIMIC-IV and 333 from MIMIC-III. Twenty-four clinically relevant parameters were selected for model construction. For the prediction of 28-day mortality of SALI in the internal validation set, the area under the curve (AUC (95% CI)) of RF was 0.79 (95% CI: 0.73-0.86), and which performed the best. Compared with the traditional disease severity scores including Oxford Acute Severity of Illness Score (OASIS), Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score II (SAPS II), Logistic Organ Dysfunction Score (LODS), Systemic Inflammatory Response Syndrome (SIRS), and Acute Physiology Score III (APS III), RF also had the best performance. SHAP analysis found that Urine output, Charlson Comorbidity Index (CCI), minimal Glasgow Coma Scale (GCS_min), blood urea nitrogen (BUN) and admission_age were the five most important features affecting RF model. Therefore, RF has good predictive ability for 28-day mortality prediction in SALI. Urine output, CCI, GCS_min, BUN and age at admission(admission_age) within 24 h after intensive care unit(ICU) admission contribute significantly to model prediction.

Cost prediction for water reuse equipment using interpretable machine learning models

During the initial stages of engineering projects management, the accurate estimation of equipment costs plays a crucial role in determining project approval decisions. However, there is a significant research gap regarding the estimation of investment costs for water reuse equipment. Additionally, cost predictions for such construction projects often suffer from limitations, including low accuracy, limited generalizability, and inefficiency. Advanced machine learning (ML) methods, renowned for their ability to model complex decision-making processes, offer powerful solutions. In this study, four traditional models and four ensemble models were employed to predict the cost of water reuse equipment. The results demonstrated that the ensemble models exhibited significantly superior predictive performance to that of traditional models with the three boosting ensemble models achieving the best performance (traditional models: training R2 = 29.77 %–94.85 %, testing R2 = 30.62 %–71.72 %; boosting ensemble models: training R2 = 97.42 %, testing R2 = 82.16 %–93.79 %). Furthermore, this study simplified the features of predictive models and identified the key variables that influence the cost of water reuse equipment using Shapley additive explanations (SHAP) method. The retrained ensemble models re-constructed based on the selected variables achieved significant predictive performance, with the Gradient Boosting Decision Tree (GBDT) outperforming the other models (training set R2 = 97.37 %, testing set R2 = 93.86 %). The water quantity, inflow conductivity, outflow conductivity, and recovery rate emerged as critical factors affecting the cost of water reuse equipment. Overall, the methods proposed in this study can enhance the versatility of cost prediction processes in environmental engineering scenarios, particularly those concerning the construction costs of water treatment equipment.

MRI radiomics based on deep learning automated segmentation to predict early recurrence of hepatocellular carcinoma.

To investigate the utility of deep learning (DL) automated segmentation-based MRI radiomic features and clinical-radiological characteristics in predicting early recurrence after curative resection of single hepatocellular carcinoma (HCC). This single-center, retrospective study included consecutive patients with surgically proven HCC who underwent contrast-enhanced MRI before curative hepatectomy from December 2009 to December 2021. Using 3D U-net-based DL algorithms, automated segmentation of the liver and HCC was performed on six MRI sequences. Radiomic features were extracted from the tumor, tumor border extensions (5 mm, 10 mm, and 20 mm), and the liver. A hybrid model incorporating the optimal radiomic signature and preoperative clinical-radiological characteristics was constructed via Cox regression analyses for early recurrence. Model discrimination was characterized with C-index and time-dependent area under the receiver operating curve (tdAUC) and compared with the widely-adopted BCLC and CNLC staging systems. Four hundred and thirty-four patients (median age, 52.0 years; 376 men) were included. Among all radiomic signatures, HCC with 5 mm tumor border extension and liver showed the optimal predictive performance (training set C-index, 0.696). By incorporating this radiomic signature, rim arterial phase hyperenhancement (APHE), and incomplete tumor "capsule," a hybrid model demonstrated a validation set C-index of 0.706 and superior 2-year tdAUC (0.743) than both the BCLC (0.550; p < 0.001) and CNLC (0.635; p = 0.032) systems. This model stratified patients into two prognostically distinct risk strata (both datasets p < 0.001). A preoperative imaging model incorporating the DL automated segmentation-based radiomic signature with rim APHE and incomplete tumor "capsule" accurately predicted early postsurgical recurrence of a single HCC. The DL automated segmentation-based MRI radiomic model with rim APHE and incomplete tumor "capsule" hold the potential to facilitate individualized risk estimation of postsurgical early recurrence in a single HCC. A hybrid model integrating MRI radiomic signature was constructed for early recurrence prediction of HCC. The hybrid model demonstrated superior 2-year AUC than the BCLC and CNLC systems. The model categorized the low-risk HCC group carried longer RFS.

Improved forecasting of the compressive strength of ultra‐high‐performance concrete (UHPC) via the CatBoost model optimized with different algorithms

AbstractThis paper focuses on the applicability of CatBoost models constructed using various optimization techniques for improved forecasting the compressive strength of ultra‐high‐performance concrete (UHPC). Phasor particle swarm optimization (PPSO), dwarf mongoose optimization (DMO), and atom search optimization (ASO), which have been very popular recently, are preferred as optimization algorithms. A comprehensive and reliable data set is used to develop the CatBoost models, which include 785 test results with 15 input features. The performance of the CatBoost models (PPSO‐CatBoost, DMO‐CatBoost, and ASO‐CatBoost) optimized with different algorithms is thoroughly assessed by means of various statistical metrics and error analysis to determine the model with the best forecasting capability, and this model is compared with the models obtained from previous studies. In addition, Shapley additive exPlanations (SHAP) analysis is used to ensure the interpretability of the forecasting models and to overcome the “black box” problem of machine learning (ML) models. The obtained results demonstrate that all CatBoost models outstandingly forecast the compressive strength of UHPC. Among these models, the DMO‐CatBoost model stands out compared to the other models in various performance metrics, such as high coefficient of determination (R2) values, low root mean squared error (RMSE), mean absolute percentage error (MAPE), and mean absolute error (MAE) values, along with a smaller error ratio. In other words, the RMSE, R2, MAPE, and MAE values of the DMO‐CatBoost model for the training set are 3.67, 0.993, 0.019, and 2.35, respectively, whereas those for the test set are 6.15, 0.978, 0.038, and 4.51. Additionally, the performance ranking of the algorithms used to optimize the hyperparameters of the CatBoost model is as follows: DMO &gt; PPSO &gt; ASO. On the other hand, SHAP analysis showed that age, fiber dosage, and cement dosage significantly influence the compressive strength of UHPC. These findings can guide structural engineers in the design and optimization of UHPC, thus assisting them in developing strategies to improve the strength properties of the material. Finally, based on the best forecasting model developed in this work, a graphical user interface has been developed to easily forecast the compressive strength of UHPC in practical applications without additional tools or software.

A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels

Glioblastoma (GBM) is the most common malignant brain tumor in adults, which remains incurable and often recurs rapidly after initial therapy. While large efforts have been dedicated to uncover genomic/transcriptomic alternations associated with the recurrence of GBMs, the evolutionary trajectories of matched pairs of primary and recurrent (P-R) GBMs remain largely elusive. It remains challenging to identify genes associated with time to relapse (TTR) and construct a stable and effective prognostic model for predicting TTR of primary GBM patients. By integrating RNA-sequencing and genomic data from multiple datasets of patient-matched longitudinal GBMs of isocitrate dehydrogenase wild-type (IDH-wt), here we examined the associations of TTR with heterogeneities between paired P-R GBMs in gene expression profiles, tumor mutation burden (TMB), and microenvironment. Our results revealed a positive correlation between TTR and transcriptomic/genomic differences between paired P-R GBMs, higher percentages of non-mesenchymal-to-mesenchymal transition and mesenchymal subtype for patients with a short TTR than for those with a long TTR, a high correlation between paired P-R GBMs in gene expression profiles and TMB, and a negative correlation between the fitting level of such a paired P-R GBM correlation and TTR. According to these observations, we identified 55 TTR-associated genes and thereby constructed a seven-gene (ZSCAN10, SIGLEC14, GHRHR, TBX15, TAS2R1, CDKL1, and CD101) prognostic model for predicting TTR of primary IDH-wt GBM patients using univariate/multivariate Cox regression analyses. The risk scores estimated by the model were significantly negatively correlated with TTR in the training set and two independent testing sets. The model also segregated IDH-wt GBM patients into two groups with significantly divergent progression-free survival outcomes and showed promising performance for predicting 1-, 2-, and 3-year progression-free survival rates in all training and testing sets. Our findings provide new insights into the molecular understanding of GBM progression at recurrence and potential targets for therapeutic treatments.

Optimizing federated learning approaches with hybrid Convolutional Neural Networks ‐ Bidirectional Encoder Representations from Transformers for precise estimation of average localization errors in wireless sensor networks

SummaryWireless sensor networks (WSNs) require precise node location in order to function properly, and they are essential in many different applications. In this research, we propose a unique method to maximize the accurate estimate of average localization errors (ALEs) in WSNs by utilizing federated learning (FL) approaches. The suggested approach combines the extraction of spatial features with collection of contextual data through integration of hybrid convolutional neural network–bidirectional encoder representations from transformers (CNN‐BERT) model. Effectively applying min–max normalization to input features minimizes data from flowing into test, validation, and training sets. The technique is centered around a collaborative learning architecture, wherein the weights of the model are iteratively assessed and modified on centralized server. The suggested methodology's effectiveness in an array of settings is illustrated by mean absolute error (MAE), mean squared error (MSE), and root mean square error (RMSE) values for node localization in WSN. Network B demonstrated accuracy with an MAE of 0.05, MSE of 0.03, and RMSE of 0.10; Network C demonstrated strong accuracy with an MAE of 0.09, MSE of 0.08, and RMSE of 0.12; and Network A generated an MAE of 0.04, MSE of 0.06, and RMSE of 0.08. Furthermore, the centralized server, which is crucial for collaborative learning, obtained exceptional MAE of 0.01, MSE of 0.02, and RMSE of 0.99 demonstrating the superiority of the FL‐optimized method in improving localization accuracy. The outcomes demonstrate the FL‐optimized hybrid model's superiority over conventional methods in providing accurate node localization in a variety of WSN settings.

Development and validation of the tic score for early detection of traumatic coagulopathy upon hospital admission: a cohort study

BackgroundCritically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the performance of a clinical score based on prehospital resuscitation parameters and vital signs at hospital admission for early diagnosis of TIC.MethodsThe score was derived from a level-1 trauma center registry (training set). It was then validated on data from two other level-1 trauma centers: first on a trauma registry (retrospective validation set), and then on a prospective cohort (prospective validation set). TIC was defined as a PTratio > 1.2 at hospital admission. Prehospital (vital signs and resuscitation care) and admission data (vital signs and laboratory parameters) were collected. We considered parameters independently associated with TIC in the score (binomial logistic regression). We estimated the score’s performance for the prediction of TIC.ResultsA total of 3489 patients were included, and among these a TIC was observed in 22% (95% CI 21–24%) of cases. Five criteria were identified and included in the TIC Score: Glasgow coma scale < 9, Shock Index > 0.9, hemoglobin < 11 g.dL−1, prehospital fluid volume > 1000 ml, and prehospital use of norepinephrine (yes/no). The score, ranging from 0 and 9 points, had good performance for the identification of TIC (AUC: 0.82, 95% CI: 0.81–0.84) without differences between the three sets used. A score value < 2 had a negative predictive value of 93% and was selected to rule-out TIC. Conversely, a score value ≥ 6 had a positive predictive value of 92% and was selected to indicate TIC.ConclusionThe TIC Score is quick and easy to calculate and can accurately identify patients with TIC upon hospital admission.

Dynamic radiological features predict pathological response after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

BackgroundNeoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is a key indicator associated with great efficacy and overall survival (OS). However, there are insufficient indicators for the reliable assessment of pCR.Methods192 patients with LA-ESCC treated with NICT from December 2019 to October 2023 were recruited. According to pCR status, patients were categorized into pCR group (22.92%) and non-pCR group (77.08%). Radiological features of pretreatment and preoperative CT images were extracted. Logistic and COX regressions were trained to predict pathological response and prognosis, respectively.ResultsFour of the selected radiological features were combined to construct an ESCC preoperative imaging score (ECPI-Score). Logistic models revealed independent associations of ECPI-Score and vascular sign with pCR, with AUC of 0.918 in the training set and 0.862 in the validation set, respectively. After grouping by ECPI-Score, a higher proportion of pCR was observed among the high-ECPI group and negative vascular sign. Kaplan Meier analysis demonstrated that recurrence-free survival (RFS) with negative vascular sign was significantly better than those with positive (P = 0.038), but not for OS (P = 0.310).ConclusionsThis study demonstrates dynamic radiological features are independent predictors of pCR for LA-ESCC treated with NICT. It will guide clinicians to make accurate treatment plans.

Different machine learning methods based on maxillary sinus in sex estimation for northwestern Chinese Han population.

Sex estimation is a critical aspect of forensic expertise. Some special anatomical structures, such as the maxillary sinus, can still maintain integrity in harsh environmental conditions and may be served as a basis for sex estimation. Due to the complex nature of sex estimation, several studies have been conducted using different machine learning algorithms to improve the accuracy of sex prediction from anatomical measurements. In this study, linear data of the maxillary sinus in the population of northwest China by using Cone-Beam Computed Tomography (CBCT) were collected and utilized to develop logistic, K-Nearest Neighbor (KNN), Support Vector Machine (SVM) and random forest (RF) models for sex estimation with R 4.3.1. CBCT images from 477 samples of Han population (75 males and 81 females, aged 5-17 years; 162 males and 159 females, aged 18-72) were used to establish and verify the model. Length (MSL), width (MSW), height (MSH) of both the left and right maxillary sinuses and distance of lateral wall between two maxillary sinuses (distance) were measured. 80% of the data were randomly picked as the training set and others were testing set. Besides, these samples were grouped by age bracket and fitted models as an attempt. Overall, the accuracy of the sex estimation for individuals over 18 years old on the testing set was 77.78%, with a slightly higher accuracy rate for males at 78.12% compared to females at 77.42%. However, accuracy of sex estimation for individuals under 18 was challenging. In comparison to logistic, KNN and SVM, RF exhibited higher accuracy rates. Moreover, incorporating age as a variable improved the accuracy of sex estimation, particularly in the 18-27 age group, where the accuracy rate increased to 88.46%. Meanwhile, all variables showed a linear correlation with age. The linear measurements of the maxillary sinus could be a valuable tool for sex estimation in individuals aged 18 and over. A robust RF model has been developed for sex estimation within the Han population residing in the northwestern region of China. The accuracy of sex estimation could be higher when age is used as a predictive variable.

MEDICAL INSURANCE PREMIUM PREDICTION WITH MACHINE LEARNING

A machine learning method for predicting health insurance rates is presented in this article. With healthcare expenditures becoming more complex, it is critical for insurance companies and policyholders to accurately estimate insurance prices. Utilizing a dataset that included medical history, demographic data, and other pertinent variables, a variety of machine learning techniques, such as ensemble methods and regression, were used to create prediction models. R-Squared and mean absolute error were two measures used to assess these models' performance. According to the developed models' results, insurance premiums can be predicted with accuracy, offering useful information for insurance counteragents. This approach has the potential to optimize pricing strategies, enhance risk assessment, and improve decision-making in the healthcare insurance sector. Machine Learning-Based Prediction of Medical Insurance Premiums Make predictions about health insurance companies based on personal traits. A dataset of policyholder attributes (such as age, gender, BMI, number of children, smoking behaviors, and geography) was gathered and preprocessed .Divide the data into sets for testing and training. Create and train a model for an artificial neural network with TensorFlow and Karas. R-squared metrics and mean R-squared error were used to assess the performance of the model. created a high R-Squared predictive model that was accurate. determined the main determinants of insurance rates. Machine learning has shown promise in estimating healthcare costs. This experiment demonstrates how well machine learning predicts medical insurance rates. Insurance companies may offer more individualized insurance plans, expedite the underwriting process, and help customers make well-informed decisions about their healthcare coverage by creating these predictive models. The created model can help policyholders make educated judgments and insurance companies establish proper prices. In the long run, our research helps the insurance industry enhance data-driven techniques, which benefits insurers as well as insured individuals in general.

A multi-parametric prognostic model based on clinicopathologic features: vessels encapsulating tumor clusters and hepatic plates predict overall survival in hepatocellular carcinoma patients

BackgroundVessels encapsulating tumor clusters (VETC) is a newly described vascular pattern that is distinct from microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Despite its importance, the current pathological diagnosis report does not include information on VETC and hepatic plates (HP). We aimed to evaluate the prognostic value of integrating VETC and HP (VETC-HP model) in the assessment of HCC.MethodsA total of 1255 HCC patients who underwent radical surgery were classified into training (879 patients) and validation (376 patients) cohorts. Additionally, 37 patients treated with lenvatinib were studied, included 31 patients in high-risk group and 6 patients in low-risk group. Least absolute shrinkage and selection operator (LASSO) regression analysis was used to establish a prognostic model for the training set. Harrell’s concordance index (C-index), time-dependent receiver operating characteristics curve (tdROC), and decision curve analysis were utilized to evaluate our model's performance by comparing it to traditional tumor node metastasis (TNM) staging for individualized prognosis.ResultsA prognostic model, VETC-HP model, based on risk scores for overall survival (OS) was established. The VETC-HP model demonstrated robust performance, with area under the curve (AUC) values of 0.832 and 0.780 for predicting 3- and 5-year OS in the training cohort, and 0.805 and 0.750 in the validation cohort, respectively. The model showed superior prediction accuracy and discrimination power compared to TNM staging, with C-index values of 0.753 and 0.672 for OS and disease-free survival (DFS) in the training cohort, and 0.728 and 0.615 in the validation cohort, respectively, compared to 0.626 and 0.573 for TNM staging in the training cohort, and 0.629 and 0.511 in the validation cohort. Thus, VETC-HP model had higher C-index than TNM stage system(p < 0.01).Furthermore, in the high-risk group, lenvatinib alone appeared to offer less clinical benefit but better disease-free survival time.ConclusionsThe VETC-HP model enhances DFS and OS prediction in HCC compared to traditional TNM staging systems. This model enables personalized temporal survival estimation, potentially improving clinical decision-making in surveillance management and treatment strategies.

Development of a CT-Based comprehensive model combining clinical, radiomics with deep learning for differentiating pulmonary metastases from noncalcified pulmonary hamartomas, a retrospective cohort study.

Clinical differentiation between pulmonary metastases and noncalcified pulmonary hamartomas (NCPH) often presents challenges, leading to potential misdiagnosis. However, the efficacy of a comprehensive model that integrates clinical features, radiomics, and deep learning (CRDL) for differential diagnosis of these two diseases remains uncertain. This study evaluated the diagnostic efficacy of a Clinical Features, Radiomics, and Deep Learning (CRDL) model in differentiating pulmonary metastases from noncalcified pulmonary hamartomas (NCPH). We retrospectively analyzed the clinical and imaging data of 256 patients from Hospital A and 85 patients from Hospital B, who were pathologically confirmed pulmonary hamartomas or pulmonary metastases after thoracic surgery. Employing Python 3.7 software suites, we extracted radiomic features and deep learning attributes from patient datasets. The cohort was divided into training set, internal validation set, and external validation set. The diagnostic performance of the constructed models was evaluated using receiver operating characteristic (ROC) curve analysis to determine their effectiveness in differentiating between pulmonary metastases and NCPH. Clinical features such as white blood cell count (WBC), platelet count (PLT), history of cancer, carcinoembryonic antigen (CEA) level, tumor marker status, lesion margin characteristics (smooth or blurred) and maximum diameter were found to have diagnostic value in differentiating between the two diseases. In the domains of radiomics and deep learning. Of the 1,130 radiomics features and 512 deep learning features, 24 and 7, respectively, were selected for model development. The area under the ROC curve (AUC) values for the four groups were 0.980, 0.979, 0.999, and 0.985 in the training set, 0.947, 0.816, 0.934, and 0.952 in the internal validation set, and 0.890, 0.904, 0.923, and 0.938 in the external validation set. This demonstrated that the CRDL model showed the greatest efficacy. The comprehensive model incorporating clinical features, radiomics, and deep learning shows promise for aiding in the differentiation between pulmonary metastases and hamartomas.

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis

BackgroundIn critically ill patients receiving invasive mechanical ventilation (IMV), it is unable to determine early which patients require tracheotomy and whether early tracheotomy is beneficial.MethodsClinical data of patients who were first admitted to the ICU and underwent invasive ventilation for more than 24 h in the Medical Information Marketplace in Intensive Care (MIMIC)-IV database were retrospectively collected. Patients were categorized into successful extubation and tracheotomy groups according to whether they were subsequently successfully extubated or underwent tracheotomy. The patients were randomly divided into model training set and validation set in a ratio of 7:3. Constructing predictive models and evaluating and validating the models. The tracheotomized patients were divided into the early tracheotomy group (< = 7 days) and the late tracheotomy group (> 7 days), and the prognosis of the two groups was analyzed.ResultsA total of 7 key variables were screened: Glasgow coma scale (GCS) score, pneumonia, traumatic intracerebral hemorrhage, hemorrhagic stroke, left and right pupil responses to light, and parenteral nutrition. The area under the receiver operator characteristic (ROC) curve of the prediction model constructed through these seven variables was 0.897 (95% CI: 0.876–0.919), and 0.896 (95% CI: 0.866–0.926) for the training and validation sets, respectively. Patients in the early tracheotomy group had a shorter length of hospital stay, IMV duration, and sedation duration compared to the late tracheotomy group (p < 0.05), but there was no statistically significant difference in survival outcomes between the two groups.ConclusionThe prediction model constructed and validated based on the MIMIC-IV database can accurately predict the outcome of tracheotomy in critically ill patients. Meanwhile, early tracheotomy in critically ill patients does not improve survival outcomes but has potential advantages in shortening the duration of hospitalization, IMV, and sedation.

Establishment of artificial intelligence model for precise histological subtyping of lung adenocarcinoma and its application to quantitative and spatial analysis.

The histological subtype of lung adenocarcinoma is a major prognostic factor. We developed a new artificial intelligence model to classify lung adenocarcinoma images into seven histological subtypes and adopted the model for whole-slide images to investigate the relationship between the distribution of histological subtypes and clinicopathological factors. Using histological subtype images, which are typical for pathologists, we trained and validated an artificial intelligence model. Then, the model was applied to whole-slide images of resected lung adenocarcinoma specimens from 147 cases. The model achieved an accuracy of 99.7% in training sets and 90.4% in validation sets consisting of typical tiles of histological subtyping for pathologists. When the model was applied to whole-slide images, the predominant subtype according to the artificial intelligence model classification matched that determined by pathologists in 75.5% of cases. The predominant subtype and tumor grade (using the WHO fourth and fifth classifications) determined by the artificial intelligence model resulted in similar recurrence-free survival curves to those determined by pathologists. Furthermore, we stratified the recurrence-free survival curves for patients with different proportions of high-grade components (solid, micropapillary and cribriform) according to the physical distribution of the high-grade component. The results suggested that tumors with centrally located high-grade components had a higher malignant potential (P<0.001 for 5-20% high-grade component). The new artificial intelligence model for histological subtyping of lung adenocarcinoma achieved high accuracy, and subtype quantification and subtype distribution analyses could be achieved. Artificial intelligence model therefore has potential for clinical application for both quantification and spatial analysis.