Imported malaria continues to be a significant cause of morbidity and mortality in the United Kingdom. Low uptake and poor compliance of chemoprophylaxis are thought to be contributory factors. Little information is available on how well health care physicians comply with malaria chemoprophylaxis when they travel to malarial areas. The aim of this study was to determine the usage and compliance of malarial chemoprophylaxis by general practitioners who have traveled to South Asia. A telephone survey of 172 general practitioners practicing in the West Yorkshire area of the UK who have traveled to South Asia. Of the 145 (84%) responding to the survey, 50 (35%) took no chemoprophylaxis, 28 (19%) did not complete the chemoprophylaxis course, and 67 (46%) were fully compliant. The reasons for noncompliance were; the belief the area visited was free from malaria (34%), no wish to take prophylaxis (18%), previous side-effects (10%), the belief of possessing long-term immunity (10%), no time to obtain prophylaxis (4%), malaria is easier to treat than to prevent (2%), costs of purchasing prophylaxis (2%), went for a short period of time and took the risk (2%), and no specific reason (18%). This study has shown that a large proportion of general practitioners questioned did not take the recommended antimalarial prophylaxis. If they themselves do not keep to the guidelines, it is of concern that they may not reinforce the taking of chemoprophylaxis by their patients. Training in travel medicine may improve chemoprophylaxis uptake by general practitioners, but until then, such physicians should not be regarded as the main provider of pretravel advice. All travelers including health care physicians should be aware, and should comply with malarial prophylaxis guidelines, with emphasis on chemoprophylaxis compliance and mosquito avoidance.