High fidelity simulation (HFS) has emerged as a crucial tool in healthcare education due to its ability to facilitate the implementation of realistic clinical scenarios. Proficiency in Cardiopulmonary Resuscitation (CPR) is imperative for nursing professionals. This study aims to explore previous literature that investigates the effects of HFS on the acquisition and retention of CPR knowledge and skills, comparing two teaching methods: (1) traditional CPR lecture accompanied by static manikin training, and (2) CPR lecture combined with high fidelity simulation training. Although high fidelity simulators have been widely utilized in various aspects of clinical nursing, their impact on the acquisition and retention of CPR knowledge and skills in nursing education remains understudied. To bridge this research gap, this study seeks to assess the effectiveness of traditional training program and high-fidelity simulation training program in enhancing the acquisition and retention of CPR knowledge and skills among nursing students. The findings of this study will contribute to the expanding body of literature on the efficacy of HFS in nursing education, offering evidence-based recommendations for the integration of HFS into CPR training programs. Ultimately, this research aims to enhance the quality of CPR education and ensure that nursing students develop the necessary competence in this vital clinical skill.