Training Awards Research Articles

NIDA‐AAAP Mentor Facilitated Training Award – Application Deadline September 30, 2024

NIDA‐AAAP Mentor Facilitated Training Award – Application Deadline September 30, 2024

Analysis of the Implementation of Re-Thinking Strategic Leadership in MSMEs for Sheet and Bed Cover Products in the City of Bandung

MSMEs in the bed linen industry often face challenges in increasingly tight market competition and changing consumer dynamics. To remain relevant and competitive in an ever-changing market, MSME leaders need to rethink their leadership strategies. Rethinking in this context includes re-evaluating business models, marketing strategies, production processes, and relationships with customers. MSME leaders need to consider new strategies that enable them to face challenges and exploit opportunities in the bedsheets industry. Based on the results of observations and in-depth interviews with MSME owners who produce bed sheets and bed covers in the Bandung area, it is clear that most of the MSME players who produce bed sheets and bed covers, especially the owners, in this case who are the leaders, have implemented re-thinking strategic leadership, especially those in the bed sheet business who produce on a large scale. . Re-thinking strategic leadership in this case means that MSME bed sheet and bed cover players have re-evaluated business models, marketing strategies, production processes and relationships with customers. MSME owners of bedsheet and bedcover products in Bandung have adopted various strategies to understand and adapt to the rapidly changing business environment. They use e-commerce and social media platforms, prioritize environmentally friendly products, adopt health protocols during the pandemic, and adjust production processes according to environmental regulations. Their strategic leadership drives adaptation through market research, product innovation, sales channel diversification, improved customer service, operational efficiency, collaboration, pricing flexibility, and human resource development. Additionally, they apply long-term thinking through SWOT analysis, market trend monitoring, competitor research, and data analysis. Team collaboration and engagement are also enhanced through cross-functional teams, open communication, shared goals, and collaborative rewards. Technology and innovation are encouraged with training, support systems, feedback loops, and innovation awards. Systemic thinking and leadership development is carried out through outreach, training, open communication, and feedback. These MSMEs also have risk awareness with appropriate risk analysis and risk mitigation as well as regular performance measurements for evaluation and strategy adjustments. MSME leaders are also considering new strategies that will enable them to face challenges and exploit opportunities in the bedsheets industry. MSME leaders in the bed linen industry have implemented strategic leadership to direct their business in a direction that is in line with the company's vision and mission. Strategic leadership involves making smart decisions, identifying market opportunities, managing risks, and developing long-term strategies. Even though the results obtained, not all MSMEs producing bed sheets are as expected.

Mapping pedagogies of education for sustainable development in Scottish higher education institutions

Sustainable Development Goal (SDG) target 4.7 promotes education for sustainable development (ESD), urging higher education institutions (HEIs) to prepare students to address global sustainability challenges. Currently, the target indicators do not assess how ESD is enacted in HEIs, making ESD provision a black box in achieving SDG 4.7. This article proposes an analytical tool based on actor–network theory (ANT) to ‘unpack’ the black box of ESD pedagogies in HEIs. ANT allows a closer look at the web of human and non-human actors and their interrelations, visually mapping how ESD pedagogical practices are enacted. Drawing on public sustainability reports and ESD-related web pages of eight Scottish HEIs, we employed a hybrid data analysis approach to produce such a map. The aggregated actor–network map reveals clusters such as university sustainability bodies, ESD-related programs, curriculum elements, co-curricular training, and sustainability awards. Also, Scottish HEI reports and web pages tend to emphasise and quantify what is taught regarding sustainability issues and not elaborate on how ESD is taught. This way, ESD pedagogical practices, connecting students, educators, and curriculum to produce transformative learning, are missing in university reporting. Making those practices visible would provide further solid evidence of Scottish HEIs’ contribution to SDG 4.7.

The National MD-PhD Program Outcomes Study: career paths followed by Black and Hispanic graduates.

Previous studies on attrition from MD-PhD programs have shown that students who self-identify as Black are more likely to withdraw before graduating than Hispanic students and students not from groups underrepresented in medicine (non-UIM). Here, we analyzed data collected for the National MD-PhD Program Outcomes Study, a national effort to track the careers of over 10,000 individuals who have graduated from MD-PhD programs over the past 60 years. On average, Black trainees took slightly longer to graduate, were less likely to choose careers in academia, and were more likely to enter nonacademic clinical practice; although, none of these differences were large. Black graduates were also more likely to choose careers in surgery or internal medicine, or entirely forego residency, and less likely to choose pediatrics, pathology, or neurology. Among those in academia, average research effort rates self-reported by Black, Hispanic, and non-UIM alumni were indistinguishable, as were rates of obtaining research grants and mentored training awards. However, the proportion of Black and Hispanic alumni who reported having NIH research grants was lower than that of non-UIM alumni, and the NIH career development to research project grant (K-to-R) conversion rate was lower for Black alumni. We propose that the reasons for these differences reflect experiences before, during, and after training and, therefore, conclude with action items that address each of these stages.

Abstract 5326: Selective deletion of estrogen receptor β in lung epithelium suppresses K-ras mutant lung tumorigenesis

Abstract Although lung cancer is the most prolific cause of global cancer-related deaths, outcomes by sex have gained traction as a means to stratify patients and tailor therapies accordingly. In recent years, females have begun to shoulder a greater burden of lung cancer diagnoses, specifically within the lung adenocarcinoma (LUAD) subtype; conversely, mortality is worsened for males. However, other sex-dependent effects in lung cancer are harder to predict. For example, hormone replacement therapy for post-menopausal women has been shown to predict better survival in some cohorts while auguring worse outcomes in others. Similar controversy exists regarding menopausal status, gender affirming care, and castration/oophorectomy status. However, there is consensus that these differential effects relate to a patient’s sex hormone composition. Estrogen, a sex hormone abounding in females, boasts well-described pro-tumor signaling in breast cancer. Unfortunately, its role in lung cancer remains elusive. Estrogen is reported to exert inflammatory properties in the lung environment, to drive immune function, and to induce proliferation of lung cancer cells. This functional antagonism has led to questions about how these compartment-specific effects are balanced. In the lung, estrogen signaling occurs mainly via estrogen receptor beta (ERβ), a nuclear hormone receptor highly expressed in lung tissue and lung tumors. ERβ is understudied relative to its sibling ERα, a well-known oncogene in breast cancer. While it is tempting to analogize ERα oncogene function to ERβ, the literature lacks consensus on the role of ERβ in lung cancer, with some authors classifying it as an oncogene and others as a tumor suppressor. In LUAD, Kras mutations encompass a quarter of driver mutations, and interaction of Kras with ERβ is understudied. Here, we tested the effects of genetic ablation of ERβ in a murine model of Kras mutant LUAD (KM-LUAD) termed CCSPCre/LSL-KrasG12D (CC-LR). Esr2 floxed mice were crossed with CC-LR mice to create a lung epithelial-specific conditional knockout of ERβ (LR/Esr2Δ/Δ). LR/Esr2Δ/Δ mice show significant decrease in tumor burden and total lung immune infiltration, indicating reduced tumor development and tumor-promoting inflammation. Of note, this effect manifests regardless of sex. RNA and protein-level analysis further suggest that ERβ deletion alters the balance of inflammatory transcription factors, resulting in skewing from STAT3- to NF-κB-driven inflammation and a net anti-tumor response. These data suggest that ERβ offers a promising early target in nascent KM-LUAD tumors with therapeutic intervention possible regardless of sex-specific effects. Acknowledgement: supported by NIH/NCI grant awarded to Seyed Javad Moghaddam (R01 CA225977); Michael J Clowers partly supported by NIH/NCI (F31 CA261121); Annamarie L Thompson supported by CPRIT Research Training Award (RP210028). Citation Format: Michael Joseph Clowers, Annamarie L. Thompson, Carlos Ignacio Rodriguez Reyna, Shanshan Deng, Seyed Javad Moghaddam. Selective deletion of estrogen receptor β in lung epithelium suppresses K-ras mutant lung tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5326.

Impact of a hypocaloric dietary intervention on antral follicle dynamics in eumenorrheic women with obesity.

Do antral follicle dynamics change in women with obesity and regular ovulatory cycles after a 6-month hypocaloric dietary intervention? After a 6-month hypocaloric dietary intervention, women with obesity and regular ovulatory cycles displayed evidence of improved antral follicle dynamics defined by the emergence of more dominant follicles, larger ovulatory follicle diameter at selection, and increased luteal progesterone concentrations compared to pre-intervention. Precise events in antral folliculogenesis must occur in order for natural and regular monthly ovulation. In healthy women of reproductive age, antral follicles are recruited for growth in a wave-like fashion, wherein a subset of follicles are selected for preferential growth, and typically, one dominant follicle culminates in ovulation. Women with obesity and regular ovulatory cycles display evidence of suppressed antral follicle development, as evidenced by fewer recruitment events, fewer selectable and dominant follicles, smaller diameter of the ovulatory follicle at selection, and a higher prevalence of luteal phase defects. While improvements in gonadotropin and ovarian steroid hormone concentrations after weight loss have been documented in eumenorrheic women with obesity, the precise impact of weight loss on antral follicle dynamics has not been evaluated. A pre-post pilot study of 12 women who participated in a 6-month hypocaloric dietary intervention. Twelve women with obesity (total body fat ≥35%) underwent transvaginal ultrasonography and venipuncture every-other-day for one inter-ovulatory interval (IOI) both before (baseline) and during the final month (Month 7) of a six-month hypocaloric dietary intervention. Participants were aged 24-34 years and had a self-reported history of regular menstrual cycles (25-35 days). Follicle number and diameter (≥2 mm) were quantified at each study visit, and individual growth profiles for all follicles ≥7 mm were determined. Blood samples were assayed for reproductive hormones. Follicle dynamics and reproductive hormone concentrations were compared pre- and post-intervention. Further, post-intervention follicle and endocrine dynamics (Month 7 IOI) were compared to an age-matched reference cohort of lean women with regular ovulatory cycles (total body fat <35%, N = 21). Participants lost an average of 11% of their original body weight with the hypocaloric dietary intervention. More dominant follicles were detected (≥10 mm) at Month 7 compared to baseline (0. 3 ± 0.4 versus 0.4 ± 0.5 follicles, P = 0.001), and ovulatory follicles were selected at larger diameters post-intervention (7.3 ± 2.0 versus 10.9 ± 2.6 mm, P = 0.007). Luteal progesterone concentrations were increased at Month 7 compared to baseline (5.3 ± 3.65 versus 6.3 ± 4.74 ng/ml, P < 0.0001). However, risk for luteal phase dysfunction as judged by the prevalence of a luteal phase length <10 days, integrated luteal progesterone levels <80 ng/ml or peak progesterone <10 ng/ml did not differ pre- versus post-intervention (all, P > 0.05). In Month 7, follicle dynamics and endocrine profiles were similar to the reference cohort across all measures. This study does not inform on the earliest stages of ovarian follicle development and is limited to providing knowledge on the later stages of antral follicle development. This study cannot fully address causation between weight loss and sustained improvements in antral follicle dynamics. The data cannot be extrapolated to comment on potential improvements in fertility and fecundity with weight loss. The small group sizes limit statistical power. The increasing prevalence of obesity necessitates an understanding of the mechanisms that underlie potential improvements in reproductive health outcomes with weight loss. Women with obesity and regular ovulatory cycles who undertook a 6-month hypocaloric dietary intervention demonstrated improvements consistent with benefits of lifestyle intervention on reproductive health even in those without overt signs of reproductive dysfunction. Potential improvements in the cellular makeup of follicles, which may underlie the restoration of normal follicle development and amelioration of subfertility, require further investigation. Cornell University, President's Council of Cornell Women, United States Department of Agriculture (Grant No. 8106), and National Institutes of Health (R01-HD0937848). B.Y.J. and H.V.B. were supported by doctoral training awards from the National Institutes of Health (T32-DK007158) and Canadian Institutes of Health Research (Grant No. 146182), respectively. The authors have no competing interests. NCT01927432 and NCT01785719.

Gearing Up: Accelerating Your CV to Promotion and Tenure.

The curriculum vitae (CV) is an important document for a faculty member and is one of the first documents reviewed by peers or evaluators when a faculty member is being considered for promotion. It catalogs the training history, accomplishments, awards, and productivity of a faculty member over time. Prior work has demonstrated how the CV should be organized and what content should be included. However, no contributions to the literature have discussed how reviewers and other academic leaders view CVs, how to structure CV entries to promote career advancement, and how CVs can become useful or limiting for faculty, regardless of whether a faculty member is actively going through the promotion process. We discuss how the CV can be seen by evaluators and concerns that can cause the CV to decelerate. We then make recommendations on how the CV can accelerate a faculty member toward academic career advancement and promotion.

Creation of an Enhanced Primary Care Registered Nurse Preceptor Role: A Pilot Project

ABSTRACT Historically, community health nursing education has not encompassed clinical sites in primary care. Primary care can be an important domain of community health nursing education. However, student practicum opportunities are limited by the number of and underutilization of RNs practicing at the full scope of their licensure (including assessment, client education, care planning and evaluation of care interventions) who can serve as student preceptors, especially in rural areas. This article describes the creation and implementation of the Enhanced Primary Care Registered Nurse (EPCRN) role in rural primary care clinics, as well as evaluates student perceptions of the EPCRN-precepted clinical experience. One nursing school used a federal training award to create the role of Enhanced Primary Care Registered Nurses (EPCRNs) to practice in federally-designated Rural Health Clinics. The EPCRNs worked in the Rural Health Clinics performing patient care and also functioned as student preceptors. Student experiences were evaluated through quantitative and qualitative methods, namely the Clinical Learning Experience, Supervision, and Nurse Teacher (CLES+T) scale and focus groups. This pilot project demonstrated positive pre-licensure student experience feedback as well as role value and sustainability for the health system. This pilot served as an example of a process for EPCRN role design within a primary care clinic site. It also demonstrated the importance of innovative, sustainable academic-practice partnerships.

Eco Friendly HRM: A Catalyst for Environmental Excellence in Hospitality

This article looks at components of human resource management (GRHM) practices to promote greater environmental performance with the goal of providing empirical proof that green HRM adoption is a key contributor to environmental performance in the hospitality industry. As a result, the part that follows summarizes the research findings and examines the literature review on GRHM practices, environmental performance, and underlying ideas. The researcher presents the research''s methodologies, findings, analysis, and conclusion in the next part.This research strategy combines literary (document) study with a qualitative methodology. The majority of local and international textbooks, papers, periodicals, sessions, websites, and electronic information, rules, laws, and regulations were employed by researchers to gather the data for this study. Google Schoolar was used to do journal searches. based on the search results discovered and choosing information that satisfies the requirements. The researcher used a systematic literature review technique to analyze the data, which entails selecting, analyzing, and interpreting a variety of data pertinent to the research topic in order to meet the study''s goals (Kitchenham and Charters, 2007).The results of numerous research demonstrate the considerable and favorable benefits of green human resource management strategies on environmental performance. Green recruitment, green training, and green awards are examples of environmentally friendly human resource management strategies that can boost an organization''s environmental performance and provide it a competitive edge Environmental protection or creating opportunities for employees to participate in ecological consultation and problem-solving groups and actively communicate with hotel industry leaders regarding environmental activities. Green performance appraisal plays an important role in achieving environmental performance as this practice provides a strategy for evaluating employee performance against environment-related standards and includes unrelated factors regarding green progress in performance feedback discussions. Environmental performance appraisal is a process through which employees are encouraged to improve their professional skills in environmental issues, thereby helping to better achieve environmental performance goals and objectives.

Impediments to Greater Diversity in the Cancer Research Workforce: Do Patterns of NCI Funding of Training and Educational Awards to Institutions With Rich Research Resources but Low Student Diversity Indicate Structural Bias?

Purpose: To examine patterns of NCI training and educational awards (T32 &amp; R25) by indicators of research capacity and student diversity. Methods: FY2019 data from the US Department of Education and NIH Exporter were used to examine student diversity and NCI funding by research capacity as defined by Carnegie Classification of Institutes of Higher Education. Results: In FY2019, the Carnegie Classification for Doctoral Universities (n = 412) included 131 “R1”_ and 135 “R2”_ research-intensive universities, and 146 other doctoral and professional universities ("DPU"_).At all Carnegie Institutions, &amp;gt;45% students were White. By Carnegie classes, compared to R2 and DPUs, R1s had the lowest proportions of African American, American Indian/Alaskan Native, Native Hawaiian and Other Pacific Islander, and female students, at both college and graduate levels. Proportions of Hispanic undergraduates were similar across Carnegie classes, and generally higher than those for Hispanic graduate students, which were lowest among R1s relative to R2s and DPUs. Asian American and nonresident alien students (undergraduate and graduate) comprised higher proportions of R1 students than those at R2s and DPUs.Schools varied by Minority Serving Institution status. For instance, numbers of Hispanic Serving Institutions were similar for R1s (16), R2s (16), and DPUs (18), but 11 R2s were Predominantly Black Institutions and only one R1 was and no DPUs. In contrast, 71 R1s were Asian American Serving Institutions, far higher than the 16 R2s and 19 DPUs with that status.Of &amp;gt;2,000 “NCI R01 and equivalent awards”_ in FY2019, &amp;gt;90% were awarded to R1s, with &amp;lt;10% at R2s and &amp;lt;1% at DPUs. Patterns by Carnegie class were similar for NCI Fellowship (F), Career Development (K), and Training Program awards (T). Conclusion: Both low student diversity at research resource-rich schools and higher diversity at schools with fewer research awards may contribute to and perpetuate few individuals from underrepresented racial and ethnic groups working in cancer research. To address this long-standing problem requires understanding how many factors and systems interact at multiple levels (e.g., individual, institutional, funding agency) to drive and block access to training and career advancement in cancer research.

WEO Newsletter.

WEO Newsletter.

Characterization of Lung Eosinophil Subsets During Respiratory Viral Infection in Mice with Pre-Existing Immunity

Abstract Eosinophils are critical cells in Type 2 immune responses and mucosal tissue homeostasis. Historically, lung eosinophilia has been linked to aberrant Th2 responses in response to inhaled allergens or as a consequence of vaccine-associated enhanced respiratory disease in viral infection. In some animal models of respiratory viral infection, lung eosinophilia has been observed in the absence of overt pathology. Here, we interrogated the phenotype and function of eosinophil subsets recruited to the lung after a sublethal, vaccine-matched intranasal challenge, modeling breakthrough infection. We observed an enrichment for eosinophils in the lungs of TIV-vaccinated mice post-challenge that were phenotypically similar to that of OVA-sensitized allergic mice, but with a marked absence of strong inflammatory cytokine signatures, detectable viral titers, and enhanced morbidity. Moreover, we did not observe an influx of eosinophils in the lungs of challenged unvaccinated mice, which were unable to control viral replication and had strong pro-inflammatory cytokine profiles. This suggests that vaccine-matched viral infection of the respiratory mucosa after priming with antigen in the periphery can result in lung eosinophilia that is neither pathological nor disease-enhancing, but correlates more so with clearance during a breakthrough infection. We longitudinally discerned the differential cellular kinetics of lung eosinophils and the lung microenvironment after breakthrough influenza infection or OVA sensitization across multiple parameters, including pathology. We are further analyzing the eosinophil compartment via RNA-seq, imaging, and spectral flow cytometry for in-depth characterization of this phenomenon. Supported by NIH Public Health Service Institutional Research T32 Training Award (AI07647) and Centers of Excellence for Influenza Research and Response (CEIRR) contract (75N93021C00014-0-9999-1).

B cell responses to membrane-presented antigens require the function of the mechanosensitive calcium channel Piezo1

Abstract It has become increasingly evident that even though B cells respond to both soluble and membrane-presented antigens in vitro, the primary mode of antigen recognition in vivo appears to be of antigens on the surfaces of antigen-presenting cells. To determine how B cells sense that an antigen is membrane associated, we investigated the role of the Piezo1 mechanosensing cation channel in human B-cell activation. We discovered that human B cells flux calcium when simply poked by a glass probe or placed on a ridged glass surface, responses that were blocked by Piezo inhibitors. Piezo1 opens in response to changes in membrane tension and we showed that B cells placed on glass but not on soft planar lipid bilayers showed increased plasma membrane tension as measured by fluorescence lifetime imaging with a membrane tension reporter. B cell calcium responses to glass surfaces and to the Piezo1 antagonist Yoda1 were independent of BCR engagement. However, critically, B cell responses to membrane-presented antigens but not to soluble anti-Ig were inhibited both by Piezo1 inhibitors and by siRNA knockdown. In the absence of Piezo-1 function B cells engaging membrane-associated anti-Ig failed to flux calcium, spread on the membrane, form an immune synapse, increase plasma membrane tension, promote actin polymerization, increase expression of CD69 or proliferate. We conclude that Piezo1 plays a pivotal role in initiation of human B cell activation to membrane antigens. Postbaccalaureate Intramural Research Training Award - NIH OITE

Avian paramyxovirus 4 has potent antitumor activity that surpasses the oncolytic effect of NDV in colon carcinoma and melanoma in vivo models

Abstract Avulaviruses make up some of the most widespread avian viral pathogens. Within the genus, APMV-1, also known as Newcastle disease virus (NDV), is the only avulavirus that has been extensively characterized and explored as an oncolytic agent. While an array of clinical and preclinical studies have shown NDV to hold much promise, the oncolytic potential of the other avulaviruses remains largely unexplored. In this study, we evaluated the in vivo anti-tumor potential of prototype strains of APMV serotypes -2, -3, -4, -6, -7, -8 and -9 in syngeneic B16–F10 melanoma and CT26.WT colon carcinoma models. All the selected viruses were able to delay tumor growth, however, treatment with APMV-4 Duck/Hong Kong/D3/1975 imparted the greatest survival benefit as well as a number of complete remissions that were protected against re-challenge in both tumor models. Infection of cancer cell lines with APMV-4 in vitro resulted in potent activation of the IFN response, and in vivo interrogation of the tumor microenvironment revealed high levels of infiltration by T cells as well as various members of the myeloid compartment. Importantly, the development of a reverse genetics approach to rescue recombinant APMV-4 viruses allowed us to successfully express GFP in the virus backbone, highlighting APMV-4 as a versatile tool that can, in the future, include therapeutic transgenes that will optimize its potential benefit in the clinic. supported in part by a Public Health Service Institutional Research Training Award AI07647

MP17-18 PROSTATE CANCER GENETIC ALTERATIONS IN HISPANIC MEN

You have accessJournal of UrologyCME1 Apr 2023MP17-18 PROSTATE CANCER GENETIC ALTERATIONS IN HISPANIC MEN Camilo Arenas-Gallo, Stephen Rhodes, Jorge A. Garcia, Lina Posada, Ilon Weinstein, Megan Prunty, Patrick Lewicki, Aaron Brant, Spyridon P. Basourakos, Christopher E. Barbieri, Fredrick R. Schumacher, and Jonathan E. Shoag Camilo Arenas-GalloCamilo Arenas-Gallo More articles by this author , Stephen RhodesStephen Rhodes More articles by this author , Jorge A. GarciaJorge A. Garcia More articles by this author , Lina PosadaLina Posada More articles by this author , Ilon WeinsteinIlon Weinstein More articles by this author , Megan PruntyMegan Prunty More articles by this author , Patrick LewickiPatrick Lewicki More articles by this author , Aaron BrantAaron Brant More articles by this author , Spyridon P. BasourakosSpyridon P. Basourakos More articles by this author , Christopher E. BarbieriChristopher E. Barbieri More articles by this author , Fredrick R. SchumacherFredrick R. Schumacher More articles by this author , and Jonathan E. ShoagJonathan E. Shoag More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003237.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer is the most common cancer among Hispanic men and a leading cause of cancer death in Hispanic countries. Differences in DNA alterations in prostate cancer among White, Black, and Asian men have been widely described. This is the first description of the DNA alterations frequency in primary and metastatic prostate cancer of Hispanic men. METHODS: We utilized the targeted next-generation sequencing tumor genomic profiles from men with prostate cancer who underwent clinical sequencing tests at academic medical centers (GENIE 11th), for a total of 4,169 patients. We used data from all institutions with the Ethnicity category available for Spanish/Hispanic, non-Hispanic White, and non-Hispanic Black men. Numbers of men by ethnicity and racial categories were analyzed via Fisher’s exact test. RESULTS: Our final cohort comprised 2,140 primary and 1,251 metastatic adenocarcinomas. Among primary cancer, TMPRSS2 alterations were less common in White men as compared with Hispanic men (32.80% vs 45.16%; p=0.017) and Black men (23.81% vs 45.16%; p=0.0009). FOXA1 alterations were present more common in Black men than Hispanic men (20.77% vs 9.20%; p=0.024). For metastatic disease, TP53 alterations were less common in White men as compared with Hispanic (44.01% vs 60.38%; p=0.023) or Black (29.36% vs 60.38%; p=<0.001) men. FOXA1 alterations occurred more frequently in White men than Hispanic men (18.85% vs 6.00%; p=0.022). No significant differences were noted in the prevalence of actionable alterations between races. As patient and tumor characteristics are unknown in this dataset, differences in these characteristics according to race were not considered in the analyses. CONCLUSIONS: There appear to be clear differences in the frequency of DNA alterations in primary and metastatic prostate cancer among Hispanic, white, and black men. Notably, we found no significant differences in the prevalence of actionable genetic alterations between the groups, suggesting that a significant number of Hispanic men could benefit from the development of targeted therapies. Source of Funding: J.E.S is supported by the Frederick J. and Theresa Dow Fund of the New York Community Trust, the Vinney Scholars Award, and a Damon Runyon Cancer Research Foundation Physician-Scientist Training Award. F.R.S. is supported by NCI CA2333216, CA043703, CA241956, and CA254566 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e219 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Camilo Arenas-Gallo More articles by this author Stephen Rhodes More articles by this author Jorge A. Garcia More articles by this author Lina Posada More articles by this author Ilon Weinstein More articles by this author Megan Prunty More articles by this author Patrick Lewicki More articles by this author Aaron Brant More articles by this author Spyridon P. Basourakos More articles by this author Christopher E. Barbieri More articles by this author Fredrick R. Schumacher More articles by this author Jonathan E. Shoag More articles by this author Expand All Advertisement PDF downloadLoading ...

MANAGEMENT OF SEWING TRAINING PROGRAM IN INCREASING THE BASIC COMPETENCE OF TRAINING PARTICIPANTS AT WORK TRAINING CENTERS, KABUPATEN SUBANG

The management of the training program is one of the success factors of the Subang Regency UPTD BLK in the awarding of the Vocational Training Award (PVA) in 2021. The sewing training program is The training program is in great demand by the community because it has ample job opportunities. This study aims to determine how far the management of sewing training programs can improve the basic competence of training participants at the UPTD BLK Subang Regency. This research uses a descriptive qualitative approach with data collection techniques namely interviews, observation, and documentation. The results of this study obtained that 1) at the planning stage, managers identify needs, develop goals, curricula, strategies, evaluation tools, facilities and training infrastructure with instructors, as well as training financing, 2) at the organizing stage, the manager forms a recruitment team, finance team, facilities and infrastructure team, reporting team, as well as instructors as training implementers, where each team works according to the implementation training schedule, 3) at the implementation stage, instructors provide teaching, guiding, and motivating participants so that they are enthusiastic about participating in the training until the program is finished, then during the training participants are active and have the motivation to learn to increase skills in sewing, then sources and learning media are also in accordance with the needs and can be used properly by training participants, 4) at the evaluation stage, the manager carries out a learning evaluation at the end of the program in the form of questions and practice. in addition, managers also carry out program evaluations to see the effectiveness of the implementation of the program, participants also take a competency test organized by the center to obtain a professional certificate. The result of organizing sewing training is an increase in knowledge, skills, and attitudes that participants feel after attending the training.

Gender bias in bangladesh civil service: a case study from 12 different cadres

This study attempts to identify the core reasons for gender bias in the Bangladesh Civil Service. The purpose is to learn about the current state of such bias and whether and to what extent women civil servants are impacted by it, as well as its consequences in terms of career growth. For this study, the researcher employed qualitative methodologies, relying mainly on primary data acquired through a questionnaire survey of 111 civil servants. Results demonstrate that in the civil service, women are subjected to a greater degree of gender bias than males, followed by the third gender. It also shows that social attitudes and lack of child care facilities are two of the key reasons for such bias and gender stereotyping, underrepresentation of women, the existing gender gap, insufficient paid maternity leaves, biased rules, and a lack of awareness might be regarded as minor sources of gender bias in this sector. Gender bias has a significant impact on postings, leadership positions, major project assignments, and challenging roles, as well as a moderate impact on other variables such as promotion, recognition for equal work, performance review, obtaining mentors and training opportunities, compensation and awards, recommendations, and recruiting, according to the data.

Award for Distinguished Contributions to Education and Training in Psychology.

This award is given by the Board of Educational Affairs in recognition of the efforts of psychologists who have made distinguished contributions to education and training, who have produced imaginative innovations, or who have been involved in the developmental phases of programs in education and training in psychology. These contributions might include important research on education and training; the development of effective materials for instruction; the establishment of workshops, conferences, or networks of communication for education and training; achievement and leadership in administration that facilitates education and training; or activity in professional organizations that promote excellence. The Career designation is added to the award at the discretion of the Education and Training Awards Committee to recognize continuous significant contributions made over a lifelong career in psychology. The 2022 recipient of the APA Distinguished Contributions to Education and Training Award in Psychology was selected by the 2021 Education and Training Awards Committee appointed by the Board of Educational Affairs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Award for Distinguished Contributions of Applications of Psychology to Education and Training: Michele Gregoire Gill.

The Board of Educational Affairs is pleased to bestow the Award for Distinguished Contributions of Applications of Psychology to Education and Training. This award acknowledges psychologists who contribute to new teaching methods or solutions to learning problems through the use of research findings or evidence-based practices. Particular emphasis is placed on the use of psychological knowledge to improve learning in educational settings, including prekindergarten to Grade 12, or in communities. The 2022 recipient of the APA Award for Distinguished Contributions of Applications of Psychology to Education and Training was selected by the 2021 Education and Training Awards Committee appointed by the Board of Educational Affairs. Michele Gregoire Gill is recognized for her influence on education and training in psychology. She founded the Galileo School for Gifted Learning, a free public K-8 charter school. The school employs a talent development model derived from the psychology of human performance and gifted achievement to build on the strengths of all students. The school's numerous awards evidence Gill's commitment to using psychological evidence to inform and sustain the development of learning environments. In 2018, APA recognized Dr. Gill as a Citizen Psychologist. She has served on the APA Council of Representatives, the Board of Educational Affairs' Coalition for Psychology in Schools and Education, and the Executive Committee of APA's Division 15: Educational Psychology. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Award for Distinguished Contributions of Applications of Psychology to Education and Training.

The Board of Educational Affairs is pleased to bestow the Award for Distinguished Contributions of Applications of Psychology to Education and Training. This award acknowledges psychologists who contribute to new teaching methods or solutions to learning problems through the use of research findings or evidence-based practices. Particular emphasis is placed on the use of psychological knowledge to improve learning in educational settings, including prekindergarten to Grade 12, or in communities. The 2022 recipient of the APA Award for Distinguished Contributions of Applications of Psychology to Education and Training was selected by the 2021 Education and Training Awards Committee appointed by the Board of Educational Affairs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).