The article shows the prerequisites for further improving the work of the internal affairs bodies of the Russian Federation and the Republic of Belarus to suppress the spread of narcotic drugs and psychotropic substances on the territory of the Union State. Based on the results of the generalization of materials, the legal basis for cooperation between the internal affairs bodies of the Russian Federation and the Republic of Belarus in the field of combating drug trafficking, information on the state of the drug situation in the territory of the Union State, measures to counter the spread of narcotic drugs and psychotropic substances in the territory of the Union State, some results of the implemented coordinated actions of internal affairs bodies, potential for further improvement of coopera-tion in the field of combating drug trafficking.