Aim. To study prognostical significance of vasomotor disorder of coronary and brachial arteries, and traditional risk factors in development of cardiovascular complications in patients with microvascular angina (MVA) and cardial syndrome X; a retrospective 12-year observation. Material and methods. Totally, 41 patient included, with MVA (40 females/1 male), mean age at the moment of inclusion 43±4,1 y.o., 15% smokers). Endotheliumdependent vasodilation (EDV) of coronary arteries was assessed via intracoronary acetylcholine load, EDV of brachial artery — via high-resolution ultrasound in active hyperemia test. Results . It was found that in brachial EDV <4,7% group the risk of cardiovascular complications (p<0,05) is higher for 9-18 years of observation. Baseline EDV of coronary arteries in the study did not influence survival rate in MVA patients. Conclusion. Significant influence on cardiovascular events occurring in long-term follow-up of MVA patients, had the risk factors as smoking and brachial artery endothelial dysfunction.