Traditional Machine Learning-based Methods Research Articles

Multi-Task Scenario Encrypted Traffic Classification and Parameter Analysis.

The widespread use of encrypted traffic poses challenges to network management and network security. Traditional machine learning-based methods for encrypted traffic classification no longer meet the demands of management and security. The application of deep learning technology in encrypted traffic classification significantly improves the accuracy of models. This study focuses primarily on encrypted traffic classification in the fields of network analysis and network security. To address the shortcomings of existing deep learning-based encrypted traffic classification methods in terms of computational memory consumption and interpretability, we introduce a Parameter-Efficient Fine-Tuning method for efficiently tuning the parameters of an encrypted traffic classification model. Experimentation is conducted on various classification scenarios, including Tor traffic service classification and malicious traffic classification, using multiple public datasets. Fair comparisons are made with state-of-the-art deep learning model architectures. The results indicate that the proposed method significantly reduces the scale of fine-tuning parameters and computational resource usage while achieving performance comparable to that of the existing best models. Furthermore, we interpret the learning mechanism of encrypted traffic representation in the pre-training model by analyzing the parameters and structure of the model. This comparison validates the hypothesis that the model exhibits hierarchical structure, clear organization, and distinct features.

On-Demand Centralized Resource Allocation for IoT Applications: AI-Enabled Benchmark

The development of emerging information technologies, such as the Internet of Things (IoT), edge computing, and blockchain, has triggered a significant increase in IoT application services and data volume. Ensuring satisfactory service quality for diverse IoT application services based on limited network resources has become an urgent issue. Generalized processor sharing (GPS), functioning as a central resource scheduling mechanism guiding differentiated services, stands as a key technology for implementing on-demand resource allocation. The performance prediction of GPS is a crucial step that aims to capture the actual allocated resources using various queue metrics. Some methods (mainly analytical methods) have attempted to establish upper and lower bounds or approximate solutions. Recently, artificial intelligence (AI) methods, such as deep learning, have been designed to assess performance under self-similar traffic. However, the proposed methods in the literature have been developed for specific traffic scenarios with predefined constraints, thus limiting their real-world applicability. Furthermore, the absence of a benchmark in the literature leads to an unfair performance prediction comparison. To address the drawbacks in the literature, an AI-enabled performance benchmark with comprehensive traffic-oriented experiments showcasing the performance of existing methods is presented. Specifically, three types of methods are employed: traditional approximate analytical methods, traditional machine learning-based methods, and deep learning-based methods. Following that, various traffic flows with different settings are collected, and intricate experimental analyses at both the feature and method levels under different traffic conditions are conducted. Finally, insights from the experimental analysis that may be beneficial for the future performance prediction of GPS are derived.

Securing web applications against XSS and SQLi attacks using a novel deep learning approach

Modern web application development involves handling enormous amounts of sensitive and consequential data. Security is, therefore, a crucial component of developing web applications. A web application's security is concerned with safeguarding the data it processes. The web application framework must have safeguards to stop and find application vulnerabilities. Among all web application attacks, SQL injection and XSS attacks are common, which may lead to severe damage to Web application data or web functionalities. Currently, there are many solutions provided by various study for SQLi and XSS attack detection, but most of the work shown have used either SQL/XSS payload-based detection or HTTP request-based detection. Few solutions available can detect SQLi and XSS attacks, but these methods provide very high false positive rates, and the accuracy of these models can further be improved. We proposed a novel approach for securing web applications from both cross-site scripting attacks and SQL injection attacks using decoding and standardization of SQL and XSS payloads and HTTP requests and trained our model using hybrid deep learning networks in this paper. The proposed hybrid DL model combines the strengths of CNNs in extracting features from input data and LSTMs in capturing temporal dependencies in sequential data. The soundness of our approach lies in the use of deep learning techniques that can identify subtle patterns in the data that traditional machine learning-based methods might miss. We have created a testbed dataset of Normal and SQLi/XSS HTTP requests and evaluated the performance of our model on this dataset. We have also trained and evaluated the proposed model on the Benchmark dataset HTTP CSIC 2010 and another SQL/XSS payload dataset. The experimental findings show that our proposed approach effectively identifies these attacks with high accuracy and a low percentage of false positives. Additionally, our model performed better than traditional machine learning-based methods. This soundness approach can be applied to various network security applications such as intrusion detection systems and web application firewalls. Using our model, we achieved an accuracy of 99.84%, 99.23% and 99.77% on the SQL-XSS Payload dataset, Testbed dataset and HTTP CSIC 2010 dataset, respectively.

MLACNN: an attention mechanism-based CNN architecture for predicting genome-wide DNA methylation

Methylation is an important epigenetic regulation of methylation genes that plays a crucial role in regulating biological processes. While traditional methods for detecting methylation in biological experiments are constantly improving, the development of artificial intelligence has led to the emergence of deep learning and machine learning methods as a new trend. However, traditional machine learning-based methods rely heavily on manual feature extraction, and most deep learning methods for studying methylation extract fewer features due to their simple network structures. To address this, we propose a bottomneck network based on an attention mechanism and use new methods to ensure that the deep network can learn more effective features while minimizing overfitting. This approach enables the model to learn more features from nucleotide sequences and make better predictions of methylation. The model uses three coding methods to encode the original DNA sequence and then applies feature fusion based on attention mechanisms to obtain the best fusion method. Our results demonstrate that MLACNN outperforms previous methods and achieves more satisfactory performance.

A Systematic Literature Analysis on the Fake Identification

Abstract- Rapid progress in AI, machine learning, and deep learning over the last few decades has resulted in new methodologies and tools for altering multimedia. Though the technology has generally been utilized for respectable causes such as entertainment and education, rogue people have also used it for illegal or evil purposes. High-quality and realistic fake movies, photos, or audios, for example, have been generated to disseminate disinformation and propaganda, incite political division and hatred, or even harass and blackmail people. Deepfake is a term that refers to modified, high-quality, realistic videos. To address the issues posed by Deepfake, many ways have been discussed in the literature. In this study, we undertake a systematic literature review (SLR) to offer an updated overview of the research efforts in Deepfake detection, summarizing 112 relevant papers from 2018 to 2020 that provided a range of techniques. We classify them into four categories: deep learning-based approaches, traditional machine learning-based methods, statistical techniques, and blockchain-based techniques. We also compare the detection capabilities of the various algorithms across different datasets and find that deep learning-based methods outperform other methods in Deepfake detection. Keyword: Deepfake detection, video or image manipulation, digital media forensics, systematic literature review.

SPD matrices representing artery anatomy for first-pass effect prediction by aggregated networks with multi-scale attentions

ABSTRACT First-pass Effect(FPE) for Endovascular Therapy(EVT) is associated with good clinical outcome (mRS2) of patients with Acute Ischaemic Stroke (AIS). A rapid and accurate prediction of FPE before EVT can help neurointerventionists plan the procedure and avoid delays in restoration of cerebral blood flow. However, there are rare studies focused on FPE prediction on arterial vessel anatomy immediately. The intractable difficulty lies in extracting discriminative features to represent a wide variety of vessels with irregular vessel shapes. In this paper, we propose a Symmetric Positive Definite(SPD) matrix-based feature representation extracted from the centerline of arterial vessels, encoding the global discriminative information over the artery for predicting FPE. Subsequently, a collaborative network of multi-scale Convolutional Neural Network(CNN) and Multiple Layer Perception (MLP) with specific attentions is developed. Specifically, the CNN is used for capturing the features among the multi-scale local neighbours of the curve. MLPs are used for capturing more prominent global discriminative features at different scales. The attention mechanism is used to better filter and extract the useful information for feature fusion. Quantitative experimental results demonstrate that our proposed method is able to predict FPE accurately, outperforming the manually defined features and traditional machine learning-based methods in this task, regarding the metrics of AUC, precision, sensitivity, specificity and accuracy.

Evaluation of Rice Degree of Milling Based on Bayesian Optimization and Multi-Scale Residual Model.

Traditional machine learning-based methods for the detection of rice degree of milling (DOM) that are not comprehensive in feature extraction and have low recognition rates fail to meet the demand for fast, non-destructive, and accurate detection. This paper presents a digital image processing technology combined with deep learning to implement the classification of DOM of rice. An improved multi-scale information fusion model of the InceptionResNet-Bayesian optimization algorithm (IRBOA) was constructed based on the Inception-v3 structure and residual network (ResNet) model. It enables to automatically extract more comprehensive features of rice and determine the DOM of rice. Additionally, the important hyperparameters in the model were tuned by the BOA to optimize the recognition rate of rice DOM. The results show the hyperparameters optimized using the BOA are those that would not be chosen in manual tuning. The classification precision of the IRBOA model reached 99.22%, 94.92%, and 96.55% for well-milled, reasonably well-milled, and substandard rice, respectively, with an average accuracy of no less than 96.90%. This model improved 7.41% over the traditional machine learning model and at least 1.35% over the fashionable CNN model with strong generalization performance. This method effectively completes rapid, non-destructive, and accurate intelligent detection of rice DOM, which can supply a reliable and accurate technical mean for rice processing enterprises to guide the rice processing process.

DLPR: Deep Learning-Based Enhanced Pattern Recognition Frame-Work for Improved Myoelectric Prosthesis Control

In EMG based pattern recognition (EMG-PR), deep learning-based techniques have become more prominent for their self-regulating capability to extract discriminant features from large data-sets. Moreover, the performance of traditional machine learning-based methods show limitation to categorize over a certain number of classes and degrades over a period of time. In this paper, an accurate, robust, and fast convolutional neural network-based framework for EMG pattern identification is presented. To assess the performance of the proposed system, five publicly available and benchmark data-sets of upper limb activities were used. This data-set contains 49 to 52 upper limb motions (NinaPro DB1, NinaPro DB2, and NinaPro DB3), Data with force variation, and data with arm position variation for intact and amputated subjects. The classification accuracies of 92.18% (53 classes), 91.56% (49 classes), 84.98% (49 classes of amputees), 95.67% (6 classes with force variation), and 99.12% (8 classes with arm position variation) have been observed during the testing. The performance of the proposed system is compared with the state of art techniques in the literature. The findings demonstrate that classification accuracy and time complexity have been improved significantly. For signal pre-processing and deep learning techniques, Keras which is a high-level API for TensorFlow is utilised to build profound learning models. The proposed method has been tested on the Intel Core i7 3.5GHz, 7th Gen CPU with 8GB DDR4 RAM.

BACPI: a bi-directional attention neural network for compound-protein interaction and binding affinity prediction.

The identification of compound-protein interactions (CPIs) is an essential step in the process of drug discovery. The experimental determination of CPIs is known for a large amount of funds and time it consumes. Computational model has therefore become a promising and efficient alternative for predicting novel interactions between compounds and proteins on a large scale. Most supervised machine learning prediction models are approached as a binary classification problem, which aim to predict whether there is an interaction between the compound and the protein or not. However, CPI is not a simple binary on-off relationship, but a continuous value reflects how tightly the compound binds to a particular target protein, also called binding affinity. In this study, we propose an end-to-end neural network model, called BACPI, to predict CPI and binding affinity. We employ graph attention network and convolutional neural network (CNN) to learn the representations of compounds and proteins and develop a bi-directional attention neural network model to integrate the representations. To evaluate the performance of BACPI, we use three CPI datasets and four binding affinity datasets in our experiments. The results show that, when predicting CPIs, BACPI significantly outperforms other available machine learning methods on both balanced and unbalanced datasets. This suggests that the end-to-end neural network model that predicts CPIs directly from low-level representations is more robust than traditional machine learning-based methods. And when predicting binding affinities, BACPI achieves higher performance on large datasets compared to other state-of-the-art deep learning methods. This comparison result suggests that the proposed method with bi-directional attention neural network can capture the important regions of compounds and proteins for binding affinity prediction. Data and source codes are available at https://github.com/CSUBioGroup/BACPI.

Automatic freezing-tolerant rapeseed material recognition using UAV images and deep learning

BackgroundFreezing injury is a devastating yet common damage that occurs to winter rapeseed during the overwintering period which directly reduces the yield and causes heavy economic loss. Thus, it is an important and urgent task for crop breeders to find the freezing-tolerant rapeseed materials in the process of breeding. Existing large-scale freezing-tolerant rapeseed material recognition methods mainly rely on the field investigation conducted by the agricultural experts using some professional equipments. These methods are time-consuming, inefficient and laborious. In addition, the accuracy of these traditional methods depends heavily on the knowledge and experience of the experts.MethodsTo solve these problems of existing methods, we propose a low-cost freezing-tolerant rapeseed material recognition approach using deep learning and unmanned aerial vehicle (UAV) images captured by a consumer UAV. We formulate the problem of freezing-tolerant material recognition as a binary classification problem, which can be solved well using deep learning. The proposed method can automatically and efficiently recognize the freezing-tolerant rapeseed materials from a large number of crop candidates. To train the deep learning network, we first manually construct the real dataset using the UAV images of rapeseed materials captured by the DJI Phantom 4 Pro V2.0. Then, five classic deep learning networks (AlexNet, VGGNet16, ResNet18, ResNet50 and GoogLeNet) are selected to perform the freezing-tolerant rapeseed material recognition.Result and conclusionThe accuracy of the five deep learning networks used in our work is all over 92%. Especially, ResNet50 provides the best accuracy (93.33%) in this task. In addition, we also compare deep learning networks with traditional machine learning methods. The comparison results show that the deep learning-based methods significantly outperform the traditional machine learning-based methods in our task. The experimental results show that it is feasible to recognize the freezing-tolerant rapeseed using UAV images and deep learning.

A computer-aided grading of glioma tumor using deep residual networks fusion

Background and objectives: Among different cancer types, glioma is considered as a potentially fatal brain cancer that arises from glial cells. Early diagnosis of glioma helps the physician in offering effective treatment to the patients. Magnetic Resonance Imaging (MRI)-based Computer-Aided Diagnosis for the brain tumors has attracted a lot of attention in the literature in recent years. In this paper, we propose a novel deep learning-based computer-aided diagnosis for glioma tumors.Methods: The proposed method incorporates a two-level classification of gliomas. Firstly, the tumor is classified into low-or high-grade and secondly, the low-grade tumors are classified into two types based on the presence of chromosome arms 1p/19q. The feature representations of four residual networks have been used to solve the problem by utilizing transfer learning approach. Furthermore, we have fused these trained models using a novel Dempster-shafer Theory (DST)-based fusion scheme in order to enhance the classification performance. Extensive data augmentation strategies are also utilized to avoid over-fitting of the discrimination models.Results: Extensive experiments have been performed on an MRI dataset to show the effectiveness of the method. It has been found that our method achieves 95.87% accuracy for glioma classification. The results obtained by our method have also been compared with different existing methods. The comparative study reveals that our method not only outperforms traditional machine learning-based methods, but it also produces better results to state-of-the-art deep learning-based methods.Conclusion: The fusion of different residual networks enhances the tumor classification performance. The experimental findings indicates that Dempster-shafer Theory (DST)-based fusion technique produces superior performance in comparison to other fusion schemes.

Specific emitter identification for IoT devices based on deep residual shrinkage networks

Specific emitter identification can distinguish individual transmitters by analyzing received signals and extracting inherent features of hard-ware circuits. Feature extraction is a key part of traditional machine learning-based methods, but manual extraction is generally limited by prior professional knowledge. At the same time, it has been noted that the performance of most specific emitter identification methods degrades in the low signal-to-noise ratio (SNR) environments. The deep residual shrinkage network (DRSN) is proposed for specific emitter identification, particularly in the low SNRs. The soft threshold can preserve more key features for the improvement of performance, and an identity shortcut can speed up the training process. We collect signals via the receiver to create a dataset in the actual environments. The DRSN is trained to automatically extract features and implement the classification of transmitters. Experimental results show that DRSN obtains the best accuracy under different SNRs and has less running time, which demonstrates the effectiveness of DRSN in identifying specific emitters.

KAICD: A knowledge attention-based deep learning framework for automatic ICD coding

Automatic International Classification of Diseases (ICD) coding is an important task in the future of artificial intelligence healthcare. In recent years, a lot of traditional machine learning-based methods have been proposed, and they achieved good results on this task. However, these traditional machine learning-based methods for automatic ICD coding only focus on the semantic features of clinical notes and ignore the feature extraction of ICD titles that are the descriptions of ICD codes. In this paper, we propose a knowledge attention-based deep learning framework called KAICD for automatic ICD coding. KAICD makes full use of the clinic notes and the ICD titles. The semantic features of clinic notes are extracted by a multi-scale convolutional neural network. For ICD titles, we use attention-based Bidirectional Gated Recurrent Unit (Bi-GRU) to build a knowledge database, which can offer additional information. Depending on input clinic notes, we can use the attention mechanism to obtain different knowledge vectors from the knowledge database where some ICD titles are more relevant to the input clinic notes. Last, we concatenate the knowledge vectors and the semantic features of clinic notes, and use them for the final prediction. KAICD is tested on a public dataset Medical Information Mart for Intensive Care III (MIMIC III); it achieves micro-precision of 0.502, micro-recall of 0.428, and micro-f1 of 0.462, which outperforms other competing methods. Furthermore, the results of the ablation study show that the knowledge database of ICD titles learned by the attention-based Bi-GRU enhances the feature expression and improves the prediction performance.

Indoor/Outdoor Switching Detection Using Multisensor DenseNet and LSTM

In recent years, with the widespread popularity of smart mobile devices, seamless location-based service (LBS) between indoor and outdoor (IO) space has become an emerging requirement. As the direct indicator of location and contextual status, accurate indoor/outdoor status guarantees stability and continuity for human localization and activity recognition. Rich-sensor smartphones have made possible various context sensing. However, it is challenging to realize fast and accurate IO switching detection in dynamic and complex environments with variable sensory signals. Toward this end, we propose a multisensor deep learning model to predict the IO state, which consists of four parts: 1) sensor vectors; 2) 1-D sensor DenseNet; 3) LSTM; and 4) MLP. Unlike the traditional feature engineering and fixed threshold strategy, we utilize 1-D sensor DenseNet to extract higher level features for different sensors, and then utilize LSTM to capture signal change pattern in time series. Finally, we leverage the MLP to classify indoor/outdoor scenes. We evaluated our proposed architecture on two data sets, one for only differentiating IO scenes and one for detecting the indoor/outdoor switching scenes. Extensive experimental results show that our proposed method outperforms the fixed threshold method, traditional machine learning-based methods, and other existing neural network-based methods in terms of switching delay and recognition accuracy.

DMFLDA: A Deep Learning Framework for Predicting lncRNA-Disease Associations.

A growing amount of evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the regulation of biological processes in many human diseases. However, the number of experimentally verified lncRNA-disease associations is very limited. Thus, various computational approaches are proposed to predict lncRNA-disease associations. Current matrix factorization-based methods cannot capture the complex non-linear relationship between lncRNAs and diseases, and traditional machine learning-based methods are not sufficiently powerful to learn the representation of lncRNAs and diseases. Considering these limitations in existing computational methods, we propose a deep matrix factorization model to predict lncRNA-disease associations (DMFLDA in short). DMFLDA uses a cascade of non-linear hidden layers to learn latent representation to represent lncRNAs and diseases. By using non-linear hidden layers, DMFLDA captures the more complex non-linear relationship between lncRNAs and diseases than traditional matrix factorization-based methods. In addition, DMFLDA learns features directly from the lncRNA-disease interaction matrix and thus can obtain more accurate representation learning for lncRNAs and diseases than traditional machine learning methods. The low dimensional representations of the lncRNAs and diseases are fused to estimate the new interaction value. To evaluate the performance of DMFLDA, we perform leave-one-out cross-validation and 5-fold cross-validation on known experimentally verified lncRNA-disease associations. The experimental results show that DMFLDA performs better than the existing methods. The case studies show that many predicted interactions of colorectal cancer, prostate cancer, and renal cancer have been verified by recent biomedical literature. The source code and datasets can be obtained from https://github.com/CSUBioGroup/DMFLDA.

Forecasting one-day-forward wellness conditions for community-dwelling elderly with single lead short electrocardiogram signals

BackgroundThe accelerated growth of elderly population is creating a heavy burden to the healthcare system in many developed countries and regions. Electrocardiogram (ECG) analysis has been recognized as effective approach to cardiovascular disease diagnosis and widely utilized for monitoring personalized health conditions.MethodIn this study, we present a novel approach to forecasting one-day-forward wellness conditions for community-dwelling elderly by analyzing single lead short ECG signals acquired from a station-based monitoring device. More specifically, exponentially weighted moving-average (EWMA) method is employed to eliminate the high-frequency noise from original signals at first. Then, Fisher-Yates normalization approach is used to adjust the self-evaluated wellness score distribution since the scores among different individuals are skewed. Finally, both deep learning-based and traditional machine learning-based methods are utilized for building wellness forecasting models.ResultsThe experiment results show that the deep learning-based methods achieve the best fitted forecasting performance, where the forecasting accuracy and F value are 93.21% and 91.98% respectively. The deep learning-based methods, with the merit of non-hand-crafted engineering, have superior wellness forecasting performance towards the competitive traditional machine learning-based methods.ConclusionThe developed approach in this paper is effective in wellness forecasting for community-dwelling elderly, which can provide insights in terms of implementing a cost-effective approach to informing healthcare provider about health conditions of elderly in advance and taking timely interventions to reduce the risk of malignant events.

Predicting Remaining Useful Life of Rolling Bearings Based on Deep Feature Representation and Transfer Learning

For the data-driven remaining useful life (RUL) prediction for rolling bearings, the traditional machine learning-based methods generally provide insufficient feature representation and adaptive extraction. Although deep learning-based RUL prediction methods can solve these problems to some extent, they still do not yield satisfactory predictive results due to less degradation data and inconsistent data distribution among different bearings. To solve these problems, a new RUL prediction method based on deep feature representation and transfer learning is proposed in this paper. This method includes an off-line stage and an online stage. In the off-line stage, the Hilbert–Huang transform marginal spectra of the raw vibration signal of auxiliary bearings are first calculated as the input, and then contractive denoising autoencoder is introduced to extract deep features with good and stable fault representation. Second, by using the obtained deep features and Pearson’s correlation coefficient, a new health condition assessment method is proposed to divide the whole life of each bearing into a normal state and a fast-degradation state. Finally, using the extracted deep features and their RUL values, an RUL prediction model for the fast-degradation state is trained by means of a least-square support vector machine. In the online stage, a kind of transfer learning algorithm, i.e., transfer component analysis, is introduced to sequentially adjust the features of target bearing from auxiliary bearings, and then the corresponding RUL is predicted using the corrected features. Results using the PHM Challenging 2012 data set show a significant performance improvement when using the proposed method in terms of predictive accuracy and numerical stability.

Evaluation of Cross-Validation Strategies in Sequence-Based Binding Prediction Using Deep Learning.

Binding prediction between targets and drug-like compounds through deep neural networks has generated promising results in recent years, outperforming traditional machine learning-based methods. However, the generalization capability of these classification models is still an issue to be addressed. In this work, we explored how different cross-validation strategies applied to data from different molecular databases affect to the performance of binding prediction proteochemometrics models. These strategies are (1) random splitting, (2) splitting based on K-means clustering (both of actives and inactives), (3) splitting based on source database, and (4) splitting based both in the clustering and in the source database. These schemas are applied to a deep learning proteochemometrics model and to a simple logistic regression model to be used as baseline. Additionally, two different ways of describing molecules in the model are tested: (1) by their SMILES and (2) by three fingerprints. The classification performance of our deep learning-based proteochemometrics model is comparable to the state of the art. Our results show that the lack of generalization of these models is due to a bias in public molecular databases and that a restrictive cross-validation schema based on compound clustering leads to worse but more robust and credible results. Our results also show better performance when representing molecules by their fingerprints.

DeepT3: deep convolutional neural networks accurately identify Gram-negative bacterial type III secreted effectors using the N-terminal sequence.

Various bacterial pathogens can deliver their secreted substrates also called effectors through Type III secretion systems (T3SSs) into host cells and cause diseases. Since T3SS secreted effectors (T3SEs) play important roles in pathogen-host interactions, identifying them is crucial to our understanding of the pathogenic mechanisms of T3SSs. However, the effectors display high level of sequence diversity, therefore making the identification a difficult process. There is a need to develop a novel and effective method to screen and select putative novel effectors from bacterial genomes that can be validated by a smaller number of key experiments. We develop a deep convolution neural network to directly classify any protein sequence into T3SEs or non-T3SEs, which is useful for both effector prediction and the study of sequence-function relationship. Different from traditional machine learning-based methods, our method automatically extracts T3SE-related features from a protein N-terminal sequence of 100 residues and maps it to the T3SEs space. We train and test our method on the datasets curated from 16 species, yielding an average classification accuracy of 83.7% in the 5-fold cross-validation and an accuracy of 92.6% for the test set. Moreover, when comparing with known state-of-the-art prediction methods, the accuracy of our method is 6.31-20.73% higher than previous methods on a common independent dataset. Besides, we visualize the convolutional kernels and successfully identify the key features of T3SEs, which contain important signal information for secretion. Finally, some effectors reported in the literature are used to further demonstrate the application of DeepT3. DeepT3 is freely available at: https://github.com/lje00006/DeepT3. Supplementary data are available at Bioinformatics online.