Traditional Herbal Treatment Research Articles

The role of medicinal plants in rheumatoid arthritis-an updated review

Rheumatoid arthritis (RA) is a debilitating, persistent autoimmune condition that affects by a variety of endogenous and external causes. It is distinguished by cartilage and bone deterioration. The present traditional allopathic treatment is costly and has negative side effects. Recently, some ethnopharmacological research on RA was published, including anti-RA properties and therapeutic targets of various dosage forms of Traditional Herbal Treatments (THMs). Given the increased herbalists' interest medicines among people suffers from rheumatoid arthritis, further research into their safety and efficacy is needed. The goal of this research was to carry out a comprehensive assessment of the evidence based on the use of herbal medications in the treatment of RA Randomised Clinical Trials (RCTs).Different chemical ingredients discovered in various herbal treatments have modest support for lowering pain, sensitive joint count, and stiffness. Herbal remedies were generally considered safe to use. More study is required to evaluate the effectiveness, safety, and potential medication interactions of the numerous herbal remedies advocated for RA.

A case report of effective traditional Chinese herbal and acupuncture treatment for postherpetic neuralgia in a very elderly patient 7 years after onset

A case report of effective traditional Chinese herbal and acupuncture treatment for postherpetic neuralgia in a very elderly patient 7 years after onset

In Silico Analysis Effect of Potential Antidiabetic from Dandang Gendis Extract on Aldose Reductase, Glucokinase, and GSK3β for Type 2 Diabetes Mellitus

Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Various epidemiological studies have shown a trend of increasing incidence and prevalence of diabetes mellitus in various parts of the world. Therefore, diabetes mellitus is currently a global health threat. Dandang gendis (Clinacanthus nutans) is a widely used plant as a traditional herbal treatment in Indonesia, and it has been proven that the ethanol extract of dandang gendis leaves shows an antidiabetic effect. This research aims to determine the compatibility among the flavonoid compounds in C. nutans with Aldose reductase, glucokinase, and GSK3β target drugs for type 2 diabetes mellitus using in silico method.Methods: 45 compounds were obtained from multiple sources. The screening method used Lipinski’s rule of five and Pyrx until 8 compounds were selected. Avogadro, AutoDock 4.2, and Biovia Discovery Studio 2016 were used for molecular docking and visualization analysis.Results: Molecular docking results demonstrate that the ligand-protein interaction’s binding energy was -7.31 to 35.25 kcal/mol for 1AH3, -7.55 to 0.15 kcal/mol for 1V4S, and -7.99 to -2.85 kcal/mol for 3D0E.Conclusion: We can conclude that flavonoid compounds Apigenin, Vitexin, 3,3-di-O-Methylellagic Acid, and Clinacoside C show a high binding affinity with Aldose Reductase, Glucokinase, and GSK3β proteins and have the potential to be oral antidiabetic drug compounds for Diabetes Mellitus. However, its binding affinity has not been able to exceed that of the native ligand of the protein. Further research is needed to determine the significant efficacy and potential as an antidiabetic.

A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants

Traditional medicine is a body of knowledge, skills, and practices based on traditional cultures' presumptions, beliefs, and experiences in order to maintain their health. Traditional herbal treatments are highly valued among many rural or indigenous people in many underdeveloped nations. According to the World Health Organization, about 80% of the world's population relies on traditional medicine, with 60% of rural Indians using herbal treatments. During the previous five years, utilization of herbal supplements grew from 2.5% to 12 percent. The assessment of novel medications, particularly phytochemically derived materials, has opened up a large arena for study and has aided India's shift from traditional to modern medicine. Tannins, alkaloids, carbohydrates, terpenoids, steroids, flavonoids, and phenols are some of the chemical components found in medicinal plants that have a distinct physiological effect on the human body. Medicinal plants do not only exhibit natural therapeutic properties, but also provide natural prevention against various diseases. As a result, we are attempting to summarize, gather the number of plants, and their ethnopharmacological qualities in this complete review study research.

POPULARITY OF AYURVEDIC MEDICINE AFTER COVID-19

Treatments for the current global COVID-19 pandemic are still being studied. There are many drugs like Antivirals and immunomodulators have had varying degrees of success in clinical trials. Traditional herbal treatments are widely used to treat a variety of ailments. for disease prevention and treatment, particularly in countries with limited resources. It is really worth noting that now in lower elevations, COVID-related mortality rates were lower. Countries in comparison to the western world other factors that contributed to the disparity nationality, temp, relative humidity, normal resistance, and nourishment are all factors to consider. Objective: The goal of this study was to find out popularity of traditional herbs were utilized in north India to protect against COVID. Method: From October to November 2021, a questionnaire-based study was done in Dehradun district at different place North India. The brief interview was conducted at the request of the participants. A pre-designed questionnaire was used to record responses (Annexure). The data was analyses using descriptive statistics. The interview drew a total of 500 participants. Mask was utilized by the majority of respondents 84%. The use of traditional herbs and spices was affirmed by 66% of the respondents. COVID positive was found in 4 % (n = 10) of the respondents' family members. Key world: COVID-19, Traditional herb, statistics, questionnaire, immunity

Antioxidants and its role in endocrine disorders

An excessive synthesis of ROS results in oxidative stress and results in deleterious process that damages cell structures i.e. lipids, proteins, and DNA. Oxidative stress plays a major role in various human disease states, including endocrine dysfunction. A number of diseases connected with free radicals have recently been reported in the medical field. The risk of diseases caused by oxidative stress is exacerbated by an unhealthy lifestyle, chemical exposure, pollution, cigarette smoking, drugs, illness, and stress, among other things. Antioxidants are molecules that can scavenge free radicals and aid in the reduction of oxidative stress-induced damage. Traditional herbal treatments and dietary items were the primary sources of antioxidants for ancient peoples, protecting them from free radical damage. In this article, we present a brief overview of the role of oxidative stress in a variety of common human endocrine disorders, such as diabetes and thyroid disease, as well as a discussion of the therapeutic potential of dietary antioxidant (Vitamin C & Vitamin A) techniques.

An Asian perspective on irritable bowel syndrome.

Irritable bowel syndrome (IBS) is a prevalent chronic disorder, and its epidemiology depends on the diagnostic criteria used. Recently, the Rome IV criteria for IBS were published by changing the frequency of abdominal pain and excluding abdominal discomfort from the previously used Rome III criteria. However, the recent Asian consensus on IBS recommends the inclusion of abdominal discomfort and abdominal pain as diagnostic criteria. The low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAP) diet has been proven to be effective in Western patients. Moreover, recent well-designed studies reported its effectiveness and the microbial changes after implementing it in Asian patients with IBS. However, traditional Korean foods including kimchi, one of representative FODMAP-rich food, exhibited a poor correlation with the food-related symptoms of IBS. Therefore, the low FODMAP diet protocol should be cautiously applied to IBS patients, especially to Korean patients with IBS. In Asian countries, there are lots of traditional herbal medicines and treatments for IBS; however, these studies have limitations including the heterogeneity of herbal mixtures and relatively small sample size. Therefore, well-designed studies based on large samples are required to validate complementary and alternative medicine in the treatment of Asian patients with IBS.

Flavonoid Profiles and Antioxidant Potential of Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum, a New Species from the Genus Monochoria C. Presl.

Plants of the genus Monochoria have long been utilized in food, cosmetics, and traditional herbal treatments. Thailand has the highest species diversity of this genus and a new member, Monochoria angustifolia (G. X. Wang) Boonkerd & Tungmunnithum has been recently described. This plant is called “Siam Violet Pearl” as a common name or “Khimuk Si Muang Haeng Siam” as its vernacular name with the same meaning in the Thai language. Despite their importance, little research on Monochoria species has been conducted. This study, thus, provides the results to fill in this gap by: (i) determining flavonoid phytochemical profiles of 25 natural populations of M. angustifolia covering the whole floristic regions in Thailand, and (ii) determining antioxidant activity using various antioxidant assays to investigate probable mechanisms. The results revealed that M. angustifolia presents a higher flavonoid content than the outgroup, M. hastata. Our results also revealed that flavonoids might be used to investigate Monochoria evolutionary connections and for botanical authentication. The various antioxidant assays revealed that M. angustifolia extracts preferentially act through a hydrogen atom transfer antioxidant mechanism. Pearson correlation analysis indicated significant correlations, emphasizing that the antioxidant capacity is most probably due to the complex action of several phytochemicals rather than that of a single molecule. Together, these results showed that this new species provide an attractive alternative starting material with phytochemical variety and antioxidant potential for the phytopharmaceutical industry.

Utilization of Acupuncture and Herbal Ointment Instead of Skin Graft Surgery for the Treatment of Burn Injuries: A Case Series and Literature Review.

Skin graft surgery is a standard treatment that increases the survival rate of patients with burn injuries; however, it leaves many sequelae. Conventional external preparations for the treatment of burns also have various side effects. In this retrospective case study, we assessed the cases of four patients with topical third-degree burns who did not wish to undergo the skin graft surgeries recommended by medical doctors and were thus treated using traditional medicine alone. A Korean medicine doctor administered integrative traditional medicine treatment to the patients using acupuncture and herbal ointments. Analysis of the patients' treatment photographs, quantitative evaluation indices, and vivid narratives suggested that their skin recovered well without adverse effects. Traditional Korean medicine treatment, including acupuncture and herbal ointment treatment, can be a new alternative therapeutic strategy for the treatment of patients with topical burns who do not want to undergo skin graft surgery or who have higher risks for poor surgical outcomes.

Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas.

Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (Salvia miltiorrhiza), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy.

Current updates on herbal oil vs synthetic antibiotics use for topical application

Topical skin infections represent some of the most common infectious sicknesses globally. Prevention and treatment of skin infections can involve utility of a topical antimicrobial, which may be an herbal oil and synthetic antibiotic drug. However, there's restricted evidence to aid the widespread rophylactic or healing use of topical agents. Challenges concerned inside the use of topical antimicrobials encompass growing costs of bacterial resistance, local allergy reactions. We evaluate the proof for the foremost scientific makes use of herbal oil and topical synthetic antibiotics. Herbal oils are traditional herbal treatments used to deal with several situations. 5% of plant oils used for dermatological usages, pores and skin moisturizing and skin care. The benefits of this sort of therapeutics encompass properly availability, local cultural elements and individual choices. the growing demand for herbal and organic merchandise, and the already established synergistic consequences of natural oil. Synthetic antibiotics are beneficial for topical administration to treating topical skin condition rather than the oral administration because of minimising the side effect of oral administration. Nowadays topical antibiotics is widely accepted effective and safe treatment for bacterial infection. In this review article comparison of the herbal oil Vs synthetic antibiotic drug for topical use.

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid loaded onto fluorescent mesoporous silica nanoparticles for the location and therapy of nasopharyngeal carcinoma.

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F) is a diterpenoid that is isolated and purified from the Chinese herbal medicine Pteris semipinnata L., and is known to exert antitumour activity in several kinds of malignant cancer cells by leading cancer cells to apoptosis. However, the antitumour effect of 5F in vivo is rarely reported due to the complexity of the physiological environment and limitations of 5F as a small anticancer drug. In the present study, we utilized FITC-doped nanoparticles for the accumulation and delivery of 5F in nasopharyngeal carcinoma CNE2 tumours transplanted in nude mice by the enhanced permeation and retention (EPR) effect. In vivo studies demonstrated that nanoparticles could efficiently deliver 5F in CNE2 transplanted tumours, and the tumour growth was effectively inhibited by the drug-loaded nanoparticles with minimal side effects. The study indicated the benefits of combining well-studied nanoparticles with traditional herbal medicine treatment and establishes a delivery platform for 5F chemotherapy.

Perceptions on preeclampsia and eclampsia among senior, older women, in rural Southwestern Uganda.

BackgroundEclampsia is among the leading causes of maternal mortality. It is a serious hypertensive complication of pregnancy and increases the risk of cardiovascular disease in later life. Pregnancy-related hypertension complications predispose to chronic hypertension and premature heart attacks. A significant proportion of women with preeclampsia/eclampsia does not reach the formal healthcare system or arrive too late because of certain traditional or cultural beliefs about the condition. The older, senior women in the community are knowledgeable and play a significant role in decision making regarding where mothers should seek maternal health care. Therefore, the purpose of this study was to explore the perceptions of older and senior women regarding the manifestation of, risk factors and possible causes of preeclampsia/eclampsia.MethodsWe conducted a qualitative study in rural Southwestern Uganda. The key informants were senior, older women including community elders, village health team members and traditional birth attendants who were believed to hold local knowledge and influence on birth and delivery. We purposively selected key informants and data were collected till we reached saturation point. We analyzed data using an inductive thematic approach to identify themes.ResultsWe interviewed 20 key informants with four themes identified. The ‘causes’ theme emerged from the subthemes of confusion with other conditions, spiritual beliefs and high blood pressure. The ‘risk factors’ theme emerged from the subthemes of oedema-related illnesses, poverty-induced malnutrition, and strained relationships. The ‘remedies’ theme emerged from the consistent mention of traditional herbal treatment, seek medical help, spiritual healing, emotional healing and corrective nutrition as potential solutions. The theme ‘effects of preeclampsia/eclampsia’ emerged from the mention of pregnancy complications like premature delivery, child loss, operative delivery like caesarian section delivery as well as death. There was no identifiable local name from the interviews. Women carried several myths regarding the cause and these included little blood, witchcraft, ghost attacks and stress from strained relationships including marital tension. Women were generally aware of the outcomes of eclampsia, mainly that it kills.ConclusionsEclampsia is associated with significant myths and misconceptions in this rural community. We recommend interventions to increase awareness and dispel these myths and misconceptions, increase access to antenatal preeclampsia surveillance, and facilitate timely referral for basic maternity care as means for early detection and management of preeclampsia.

ICP-MS assisted heavy metal analysis, phytochemical, proximate and antioxidant activities of Mimosa pudica L

Medicinal plants and traditional herbal treatments have been emerging as a source of highly recommended yet scientific method of disease management. Mimosa pudica Linn, the chosen plant is a commonly seen, ornamental plant also known as shy plant, touch me not, etc. Heavy metals are naturally occurring in the environment. Heavy metals exposure can cause severe health issues sometimes even lead to death in human beings. The prime aim of this work was to evaluate the presence of trace elements and heavy metals in the plant. ICP-MS was the technique employed in elemental analysis. The soil where the plant grew was also tested for mineral quantification. Flower extract of the M. pudica was also used for phytochemical analysis, proximate analysis, antibacterial activity and antioxidant activity. Elemental analysis showed that the concentration of elements in the plant was found to be in the increasing order of Cu > K > Ca > Mg > Fe > Mn > Zn > Ni > Pb > Cr > Co > As > Cd. The values of Ni, K, Pb and Cu were slightly beyond the permissible limit. Phytochemical analysis confirmed the major classes of phytochemicals which includes, glycosides, phenols, terpenoids, flavonoids, steroids, proteins, alkaloids etc. Proximate analysis expresses the physicochemical nature of the sample. The results of antioxidant activity showed a positive result. Hence the study emerges with good results suggesting that Mimosa pudica is a strong candidate in the herbal medicinal field.

SELF CARE TRADITIONAL HERBAL THERAPY FOR PSORIASIS

Background: Psoriasis a skin ailment leading to frustration, stress and social isolation is a vital health problem to be addressed. Research in the area of herbal medicine and rejuvenation practice is based on the number of Random trials in the prevalence of a disease and a survey on the number of published in the journals indexed in the subject area.
 Objective: To document successful casestudies and suggest the progressive herbal treatment plan carried out in Rajendra Herbal Research and training centre.
 Methodology:In a survey of 1000 patients with reported skin problems undergoing traditional herbal and Ayurvedic treatment, 554 had scratchy itch related skin problems, 215 bite based blisters, 32 Hair related Allopecia, 47 White patch, 36 Black patch, 49 psoriasis and 67 patients had red rashes. The group had 518 males and 482 females. Five sets of skin patients were chosen for a cohort study with 0 to 70 years of age having151, 149, 149,154 &175nos.An experiment was designed to carryout a randomized double blind placebo controlled study in 140 psoriatic patients.
 Results: Random survey of 1000 skin patients and cohort study of five sets of herbal respondents of agegroup 0-70 were tabulated.Out of the 140 treated Psoriatics, sixcase studies presented with the treatment plan followed at the Rajendra Herbal Research centresshowedsuccesstowards positive health.
 Conclusion:In all the sets females out-numbered males with the prevalence of skin problems in 11 to 40 years of age. More females of the age group 41 to 50 ended up in Psoriatic arthritis and males with Diabetes. Rajendra supportive herbal therapy for Psoriasis promises social freedom and psychological harmony.

Envenenamento fatal por mordedura de Naja Nigricollis em Angola e uso da terapia tradicional: um caso clínico em Benguela

Introdução: O envenenamento por mordedura de serpentes constitui um importante problema de Saúde Pública e uma emergência médico-cirúrgica frequente, que afecta as comunidades rurais de África. É responsável por elevado número de vítimas que podem evoluir para morte, principalmente nas áreas rurais, onde estas comunidades são as que mais sofrem por viverem longe dos serviços de saúde, acabando por submeterem-se a tratamentos tradicionais impedindo o manuseio precoce e adequado dos casos em ambiente hospitalar. O presente artigo tem como objectivo descrever o primeiro caso clínico fatal ocorrido numa criança na Província de Benguela - Angola com envenenamento por naja nigricollis, a espécie que é considerada a segunda mais perigosa de África a seguir à Dendroaspis polylepsis. Trata-se de uma criança que foi mordida de noite no pescoço e pé direito. Durante cinco dias os pais submeteram-na a tratamento tradicional fitoterapêutico com um curandeiro, tendo a mesma acorrido ao Hospital Geral de Benguela com um quadro séptico de fasceíte necrotizante grave, anemia severa tendo-se realizado a necrectomia das regiões afectadas e tratamento adequado da anemia. Resultados: A morte da criança após 4 dias nos cuidados intensivos do mesmo Hospital. Conclusões: A fatalidade deste caso clínico demonstra que apesar do manuseio clinico cirúrgico tardio adequado o espectro da gravidade do envenenamento por naja nigricollis ainda constitui uma realidade que poderia ser evitada se educássemos as nossas comunidades rurais em relação à crença do uso de terapias tradicionais nos acidentes ofídicos em Angola.

Acritical examination of the main premises of Traditional Chinese Medicine.

SummaryTraditional Chinese Medicine (TCM) consists of a plethora of therapeutic approaches aiming to both characterize and treat diseases. Its utilization has gained significant popularity in the western world and is even backed by the World Health Organization’s decision to include TCM diagnostic patterns into the new revision of the International Classification of Diseases code, the global standard for diagnostic health information. As these developments and potentially far-reaching decisions can affect modern healthcare systems and daily clinical work as well as wildlife conservation, its underlying factual basis must be critically examined. This article therefore provides an overview of the evidence underlying the basic TCM concepts, such as Qi, meridians, acupuncture, pulse and tongue diagnostics as well as traditional herbal treatments. Moreover, it discusses whether scientific literature on TCM reflects the current standard for evidence-based research, as described in good scientific practice and good clinical practice guidelines. Importantly, misinformation regarding the therapeutic efficacy of animal-derived substances has lead and currently leads to problems with wildlife preservation and animal ethics. Nevertheless, the (re-)discovery of artemisinin more than 50 years ago introduced a novel development in TCM: the commingling of Eastern and Western medicine, the appreciation of both systems. The need for more rigorous approaches, fulfilment of and agreement to current guidelines to achieve high-quality research are of utmost relevance. Thereby, ancient knowledge of herbal species and concoctions may serve as a possible treasure box rather than Pandora’s box.

Antibacterial activity, phytochemicals and essential oils in ethyl acetate extract of Cleistopholis patens

The ethyl acetate extract of Cleistopholis patens was investigated for its antibacterial activity against ten bacterial strains and compared with standard antibiotics. The extract was purified and antibacterial activities were compared with the crude extract. The multiple antibiotic resistant (MAR) index was determined using known method. The phytochemical components were examined and the essential oil components were also investigated using the GC-MS spectra analysis. The antibacterial test revealed the plant to be active against the test organisms. However, the crude extract showed larger zones of inhibition compared to the purified extract. The multiple antibiotic resistance (MAR) index ranged between 0.42 and 1.0. The phytochemical analysis revealed the presence of glycosides, steroids, phenols and tannin. Mineral content of plants are Na (24.03%), K (30.14%), Ca (32.31%), Mg (26.09%), Zn (28.09%), Fe (6.70%) and Cu (0.03%). The GC-MS analysis showed the presence of essential oils predominantly fatty acids, sterols, esters, terpenes and alcohols with fatty acid occurring in abundance. The presence of essential oil in this plant could be responsible for its biological activities and the result of this work supports the use of the plant in the traditional medicine and herbal treatment of diseases.

Hepatitis A-associated cholestasis and aplastic anemia

Hepatitis A virus (HAV) infection in children is typically an acute, self-limited illness associated with general, nonspecific symptoms. Prolonged cholestasis is a rare atypical form of HAV infection that is characterized by serum bilirubin levels higher than 10 mg/dl for more than 12 weeks. Aplastic anemia is another very rare complication of HAV. We report the case of an 11-year-old male with blood group O Rh positive who developed cholestasis followed by aplastic anemia postfulminant HAV infection. Liver function tests rapidly responded to a short course of steroid treatment. The patient had a sickle cell trait and a variant of ABCB11 gene. There was no history of traditional herbal treatment, but we noticed several cautery marks. Immunosuppressive medication was started for aplastic anemia, and he is listed for urgent bone marrow transplant. This is the first reported case of prolonged cholestasis followed by aplastic anemia complicating fulminant HAV infection in a Libyan adolescent.

Inventory of Medicinal Plants for Pregnant and Postpartum Women in Dayak Tomun of The Lopus Village Lamandau Regency of Central Kalimantan

Dayak Tomun is a traditional society living in the Lamandau Regency of Central Borneo. The Dayak society Tomun has local wisdom in the treatment and care of pregnant women and the brithing process utilizies medicinal plants. The traditional medicines were passed down from the ancestors of the Dayak. The purpose of the research was to discover, assess, and inventory medicinal plant used in the treatment and care of pregnant and postpartum women by the Dayak Tomun. The method used was a semi-structured interview and direct participatory observation of six key informants professional activities in the treatment of Dayak Tomun in the Lopus Villages. As many as 17 species of medicinal plants with 14 families. Found of these 23.53% were of member of the family Zingiberaceae. Traditional herbal treatment of pregnant and postpartum by Dayak Tomun societies many are formulated by using part of the leaves (52%), boiled (37.50%) and consumed with a drink (28%). Treatment and care of pregnant and postpartum women in Dayak Tomun should be applied and preserved so that local knowledge of Dayak Tomun society in the Lopus Villages is not lost to the next generation. The research provided information to the society about the utilization of plants used in treatment for women.