Antibiotics have significantly helped treat various infectious diseases and thus reduced mortality rates around the globe. But over time, these pathogens have become resistant to these antimicrobial agents, worsening the scenario in life-threatening infectious diseases. Antimicrobial resistance happens when microorganisms (such as bacteria, fungi, viruses, and parasites) change when exposed to antimicrobial drugs (such as antibiotics, antifungals, antivirals, antimalarials, and anthelmintic agents). The present review study explored various Ayurvedic methods, modalities, and medicines to develop a sustainable and innovative mechanism to combat the current problem of AMR. The Ayurvedic approach to the prevention and treatment of microbial infection recognises the emergency use of modern drugs but recommends traditional herbal combinations and extracts known to balance the individual and improve health, as well as herbs that help to combat or prevent microbial infections. Some solutions can be to increase the host's immunity through therapy, and proper use of Dhatupachaka Kashaya prescribed in Ayurveda in combination with antibiotics. There is a scope for further exploration and research in this area.