Background: North-eastern India is renowned for its rich bio-diversity of indigenous medicinal plants and its therapeutic properties. The tribal communities and ethnic groups residing in this region genuinely depend on the indigenous systems of medicine. They have extensive knowledge and comprehension of plants, both conventional and non-conventional, for their food and medicine, and they practice their own traditional healthcare system. Objectives:This study aims to give a systematic overview of traditional medicinal plants along with their properties used by the Scheduled Tribe (ST) communities of north-eastern region and their potential for upliftment of the socio economic status of the community. Methods: The data were collected from published paper through electronic databases viz, Google scholar, PubMed, Science Direct based on traditional medicinal plants used by the ethnic groups. Results: In this study, 236 medicinal plants were summarized with their medicinal properties used by the Scheduled Tribe people of northeastern region. Conclusion: This study provides the information on therapeutic plants which will be a valuable resource for creating an action plan and development for the herbal drug sector, with the goal of enhancing and boosting the state's economy and quality of life.