Within high-precision indoor environments, such as semiconductor fabrication or textile plants, humidity control is paramount for preserving product integrity and reducing energy expenditure. The non-uniform indoor air environment poses a significant challenge in achieving humidity regulation that meets the distinct requirements of various locations. Traditional feedback control mechanisms may lead to instability, overshooting, and oscillation in indoor parameters. This paper proposes a comprehensive method to address humidity assurance issues in high-precision indoor environments by establishing analytical expressions that link the demand parameters at different locations with air supply parameters. Using a case study, this paper examines several typical operational scenarios with diverse control objectives, including minimizing dehumidification energy consumption, minimizing air supply humidity adjustment values, and constraints on adjustable air supply inlets. This method enables rapid calculation of air supply humidity and regulation of humidity parameters at multiple locations within the indoor environment. It considers various locations, requirements, optimization targets, and precision, demonstrating that it can quickly determine the optimal air supply parameters based on the objective function. This method facilitates rapid adjustment and high-precision assurance of different humidity requirements at multiple locations, making it suitable for high-precision design and control of indoor humidity environments.