Today's machining shop floors, characterized by large variety of products in small batch sizes, require dynamic control and real-time monitoring capabilities that are responsive and adaptive to the rapid changes of production capability and functionality. It is especially true when the shop floors are combined with the e-manufacturing concept. However, a highly efficient infrastructure that can integrate the pieces of automated equipment together and link them to the e-manufacturing is still missing. The objective of this research is to develop an appropriate methodology with open architecture for real-time monitoring and remote control of networked CNC machines. A framework named Wise-ShopFloor (Web-based-integrated sensor-driven e-ShopFloor) is designed for this purpose. Within the context, this paper presents a new enabling technology to bring traditional CNC machine tools on-line with combined monitoring and control capability. Issues such as architecture design, methodology development, and prototype implementation are addressed through a milling machine case study. It is expected that the developed technology can be readily applied to real shop floor environments with increased productivity, flexibility, and responsiveness.