You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 20122106 URINE TMPRSS2:ERG FUSION TRANSCRIPT INTEGRATED WITH PCA3 SCORE, GENOTYPING, AND BIOLOGICAL FEATURES ARE CORRELATED TO THE RESULTS OF PROSTATIC BIOPSIES IN MEN AT RISK OF PROSTATE CANCER Jean-Nicolas Cornu, Géraldine Cancel-Tassin, Chirstophe Egrot, Cecile Gaffory, François Haab, and Olivier Cussenot Jean-Nicolas CornuJean-Nicolas Cornu Paris, France More articles by this author , Géraldine Cancel-TassinGéraldine Cancel-Tassin Paris, France More articles by this author , Chirstophe EgrotChirstophe Egrot Paris, France More articles by this author , Cecile GafforyCecile Gaffory Paris, France More articles by this author , François HaabFrançois Haab Paris, France More articles by this author , and Olivier CussenotOlivier Cussenot Paris, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2274AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Detection of fusion gene TMPRSS2:ERG transcripts in urine have been recently described in order to refine urine-based detection of prostate cancer (PCa). Our objective was to investigate the correlation of TMPRSS2:ERG urine detection, Prostate Cancer Antigen 3 (PCA3), Prostate Specific Antigen (PSA) density, 8q24 PCa susceptibility genotypes and androgenic status with outcome and pathological findings at prostatic biopsy. METHODS Between 2007 and 2011, 291 patients at risk of PCa because of PSA>3.0 ng/mL (55%) or candidate to active surveillance protocol justifying restaging biopsy management (45%) were recruited. TMPRSS2:ERG fusion transcript (T2-score) was detected by urine assay (GenProbe, San Diego, CA, USA). PCA3-score, PSA level, bioavailable testosterone (baT) level, prostate volume, genotypes for 8q24 single nucleotide polymorphisms rs1447295 and 6983267, and usual clinical data were assessed for all patients. Univariate and multivariate analysis by logistic regression model (logit) evaluated the correlation of T2-score, PCA3, PSA density, genotype, baT level, age and familial history with biopsy results, and Gleason score. RESULTS Of 291 patients, 173 had PCa and 118 had negative biopsy. PCA3-score, PSA density and T2-score were correlated with presence of PCa (p<0.0001, p=0.046, and p<0.0001 respectively). This correlation remained strong on multivariable analysis prediction model (figure and table). PCA3-score and PSA density were significantly associated with presence of grade 4 through multivariable model (p=0.029 and p=0.03, respectively), with a trend for an association with T2-score (p=0.052). AUC for grade 4 prediction was 0.804. PCA3 score was also correlated to the percentage of positive cores at biopsy (p=0.008). CONCLUSIONS Integration of T2-score, with PCA3-score, androgenic status, genetic status and traditional clinical variables could significantly increase detection of high risk localized PCa. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e849-e850 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jean-Nicolas Cornu Paris, France More articles by this author Géraldine Cancel-Tassin Paris, France More articles by this author Chirstophe Egrot Paris, France More articles by this author Cecile Gaffory Paris, France More articles by this author François Haab Paris, France More articles by this author Olivier Cussenot Paris, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...