Traditional Ayurvedic Formulation Research Articles

A clinical study to evaluate the efficacy of Shaliparnyadi Yusha in Garbhini Parshwagraha (Flank Rigidity with Lower Back Pain) During the Second and Third Trimester

This study investigates the efficacy of Shaliparnyadi Yusha, a traditional Ayurvedic formulation, in the management of Garbhini Parshwagraha (flank rigidity associated with lower back pain) during the second and third trimester of pregnancy. The study was conducted on 32 patients, with outcomes measured by reductions in pain and improvements in mobility. The results indicate significant relief of symptoms, supporting the use of this Ayurvedic therapy for pregnant women experiencing discomfort due to musculoskeletal strain.

Comprehensive profiling of traditional herbomineral formulation Manasamitra vatakam in rat brain following oral administration and in-silico screening of the identified compound for anti-Alzheimer's activity

Ethnopharmacological relevanceMulti-targeted drug therapy has received substantial attention for the treatment of diseases of multifactorial origin, such as neurodegenerative diseases. Manasamitra vatakam (MMV) is a traditional Ayurvedic formulation used to improve cognitive impairment and mental illness. Here we have used a unique method for leveraging the barrier properties of the intestinal and blood-brain barrier (BBB) to screen and identify the bioactive molecules against Alzheimer's disease (AD). The current method exemplifies a facile method to expedite drug discovery from traditional formulations. Aim of the studyThe present study aimed to identify the phytoconstituents of MMV that reach the brain tissue and to predict major bioactive constituents by computational docking studies. Materials and methodsAfter oral administration of the formulation, brain samples from male Sprague Dawley rats were collected at different time intervals and analyzed by liquid chromatography-mass spectrometry (LC-MS) to identify the phytoconstituents. In silico molecular docking studies were carried out to analyze the binding affinity of the compounds to the target proteins of AD using Schrodinger Maestro. The molecular dynamic studies were carried out for all the docked complexes having higher docking scores. Results34 phytoconstituents were identified by LC-MS analysis of brain homogenates. In the in silico docking study, the phytoconstituents chrysin, convolvin, rutin, galangin, palmatoside G, isoliquiritigenin, quercetin, and naringenin showed higher docking score against the target proteins of AD. These compounds may serve as the primary bioactive compounds responsible for the neuroprotective activity of the herbal formulation. Furthermore, molecular dynamic studies indicated that the galangin-acetylcholinesterase enzyme complex has the highest stability among these eight compounds. ConclusionThe study, together with previous in vivo and in vitro efficacy results, suggests that BBB-permeable compounds with high binding affinities for the target proteins of AD might be responsible for the effectiveness of MMV against AD.

Phytochemical Analysis and In Vitro Evaluation of Antidiabetic Potential of Banana Bract Lehya

Banana Bract Lehya, a traditional Ayurvedic formulation, has gained recognition for its potential therapeutic applications. This study aimed to prepare and evaluate the physicochemical properties and biological activities of Banana Bract Lehya. The lehya was prepared using banana bract powder (Musa paradisiaca), jaggery, tamarind, and a blend of spices including cumin, ajwain, ginger, fennel, and black pepper. Phytochemical screening revealed the presence of various bioactive compounds, with high concentrations of flavonoids and phenolic compounds, and moderate levels of tannins and terpenoids. Physicochemical analysis showed a pH of 6.20, loss on drying of 70%, total ash content of 3.2%, and total solid content of 96%. Organoleptic evaluation indicated a light brown and black color, pungent and spicy taste, and jelly-like texture. The total phenolic content was 78.5 ± 3.2 mg GAE/g, while the total flavonoid content was 42.3 ± 2.1 mg QE/g. Antioxidant activity, assessed by DPPH free radical scavenging assay, showed an IC50 value of 127.6 ± 5.4 μg/mL, compared to ascorbic acid's 23.8 ± 1.2 μg/mL. Glucose adsorption capacity increased with rising glucose concentration, suggesting potential anti-diabetic effects. The lehya exhibited concentration-dependent inhibition of α-amylase and α-glucosidase enzymes, with IC50 values of 156.3 ± 7.2 μg/mL and 143.7 ± 6.5 μg/mL, respectively, compared to acarbose's 83.2 ± 3.8 μg/mL and 95.6 ± 4.1 μg/mL. These findings provide valuable insights into the composition, physicochemical properties, and potential health benefits of Banana Bract Lehya.

CRITICAL REVIEW OF PASHANBHINNA RASA ON ASHMARI WITH SPECIAL REFERENCE TO UROLITHIASIS

Ayurveda, an ancient system of medicine, addresses numerous disorders related to the Mutravaha Srotas (uri-nary system), such as Mutrakricchra (dysuria), Mutraghata (obstructive uropathy), and Mutrashmari (urinary calculi). Among these, Mutrashmari, corresponding to urolithiasis in modern medicine, is one of the most com-mon and distressing conditions, characterised by the formation of stones within the urinary tract. Sushruta iden-tifies two primary mechanisms of stone formation: urine stagnation and supersaturation and crystallisation of urinary crystalloids. Urolithiasis affects approximately 12% of the global population, with a high recurrence rate, especially in males. This review aims to provide a comprehensive analysis of Pashanbhinna Rasa, a herbo-mineral formulation from the Bhaishajya Ratnavali, Ashmari Prakaran, assessing its efficacy in treating Ash-mari (urolithiasis)—the study endeavours to bridge the knowledge gap in contemporary literature regarding this formulation. A thorough literature review focused on references to Pashanbhinna Rasa in classical Ayurvedic texts and modern scientific studies. The review highlights Pashanbhinna Rasa's multifaceted approach to man-aging urolithiasis. The herbo-mineral components of Pashanbhinna Rasa are believed to exert a synergistic ef-fect, potentially dissolving stones, preventing their formation, and providing symptomatic relief. This critical review elucidates the potential of Pashanbhinna Rasa as an effective treatment for urolithiasis. While traditional Ayurvedic formulations offer promising therapeutic benefits, further clinical studies are necessary to validate their efficacy scientifically. Establishing Pashanbhinna Rasa as a standardised treatment could integrate Ayur-vedic wisdom with modern medical practice, offering a holistic approach to managing urolithiasis.

The effect of an Indian traditional Ayurvedic formulation (Rasa-sindoor) on Parkinson disease mouse model

The effect of an Indian traditional Ayurvedic formulation (Rasa-sindoor) on Parkinson disease mouse model

Efficacy of Ayurveda interventions and lifestyle versus lifestyle interventions alone in grade I and II non-alcoholic fatty liver disease: Protocol for a multicenter exploratory pilot randomized controlled trial

Abstract INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health issue affecting 20%–30% of adults, with dominance in men, particularly in the obese population. Current interventions focus on lifestyle modifications, highlighting the need for effective pharmacological options. This study explores the clinical efficacy of Arogyavardhini Vati and Pippalyadyasava, traditional Ayurvedic formulations, in the management of NAFLD. BACKGROUND AND RATIONALE: With Ayurvedic medicine emphasizing holistic well-being, this study is aimed to assess the efficacy of Ayurveda interventions viz., Arogyavardhini Vati and Pippalyadyasava combined with lifestyle modifications in grade I and II NAFLD. MATERIALS AND METHODS: The study includes individuals aged 18–60 years and diagnosed with NAFLD of grade I or II. The intervention arm receives Arogyavardhini Vati and Pippalyadyasava along with lifestyle modifications, while the control group adopts lifestyle modifications for 90 days. Both groups are then followed up for more than 30 days with lifestyle modifications ongoing. Primary outcomes include the change in the fibroscan score and controlled attenuation parameter value or magnetic resonance imaging proton density fat fraction. Secondary outcomes are changes in liver function markers, lipid profile, HbA1C, Body Mass Index, and Fatty Liver Index. CONCLUSION: This study may inform about the efficacy of the Ayurvedic interventions adjuvant to lifestyle modification in the management of NAFLD. TRIAL REGISTRATION: CTRI/2022/02/040321 dated February 15, 2022.

Formulation and Evaluation of Herbal Churna for Constipation

Formulation and evaluation of herbal churna for constipation. • Churna is a very famous ayurvedic medicine for constipation. It is a traditional ayurvedic medicine. • The goal of treatment relives the cause of constipation and to promote regular and predictable bowel movement. • Regulates bowel movement. • Relieves frequent and chronic constipation. • Helps to pass stool more smoothly. • churna is a very famous Ayurvedic medicine for constipation. It is not a traditional Ayurvedic medicine. • It is a proprietary Ayurvedic medicine. It means that the formula of Kayam churna is not mentioned in any Traditional Ayurvedic text books. • The manufacturer of Churna, Sheth Brothers, formulated a combination of few Ayurvedic herbs that benefit in constipation, blended them into powder form and labelled it as churna. • As the standardization of herbal formulation is great concern for its safety and efficacy for that reason this work is aimed to formulation comparative evaluation of churna with marketed product. Churna, a traditional Ayurvedic formulation, has been used for centuries to treat constipation. The powder, composed of a blend of natural herbs and ingredients, stimulates bowel movements, softens stools, and relieves straining during defecation. With its natural and safe composition, Churna offers a cost-effective and minimally invasive solution for managing constipation. These abstract reviews the ingredients, preparation, and pharmacological properties of Churna, highlighting its potential as a natural remedy for constipation relief..

Standardization and Quality Assessment of Drakshavaleha: Insights from Three Marketed Brands

Drakshavaleha, a traditional Ayurvedic formulation, is widely used for its therapeutic benefits in treating respiratory and digestive ailments. This study aims to standardize and evaluate the quality of Drakshavaleha from three different marketed brands through a comprehensive assessment of their physicochemical and pharmacognostical properties, alongside an estimation of toxic heavy metals content and microbial contamination, and phytochemical profiles. Materials and Methods: Three brands of Drakshavaleha were meticulously assessed through a range of tests, including organoleptic analysis, physicochemical evaluations, heavy metal content analysis, microbial contamination assessments, and qualitative phytochemical screenings. Standardized protocols and methodologies from pharmacopoeias were used for all evaluations to ensure reliable and consistent results. Results and Discussion: The findings indicated notable variations in the evaluation parameters of the different brands. Physicochemical and Pharmaceutical analysis revealed disparities in pH levels and total reducing sugar levels. Heavy metal testing and microbial contamination levels were within acceptable ranges for all samples. The qualitative phytochemical screening identified differences in the concentration of key active ingredients, potentially impacting therapeutic efficacy. Conclusion: This study underscores the importance of standardization in maintaining the safety and efficacy of Ayurvedic formulations. By identifying variations in quality and safety parameters, it provides critical insights for manufacturers to improve their production processes. Ultimately, this research advocates for enhanced quality assurance practices to uphold the integrity of Ayurvedic medicine in the global market.

Pharmaceutical Preparation of Amrita Guggulu and its Clinical Efficacy on Vatarakta

This study scrabbles about into the pharmaceutical preparation of Amrita Guggulu, a traditional Ayurvedic formulation known for its therapeutic properties. The focus of the research is on assessing the clinical efficacy of Amrita Guggulu in managing Vatarakta, a condition characterized by vitiated Vata as well as Pitta and associated with inflammatory joint disorders. The pharmaceutical preparation involves meticulous formulation techniques, ensuring the quality and potency of the final product. Standardization parameters include the selection of authentic raw materials, adherence to traditional preparation methods and quality control measures. Clinical Trial Design: The clinical trial was designed as a randomized, double-blind study to assess the efficacy of Amrita Guggulu in patients diagnosed with Vatarakta. Participants were randomly assigned to either the treatment group receiving Amrita Guggulu group A or group B. A comprehensive clinical trial was conducted to evaluate the efficacy of Amrita Guggulu in patients diagnosed with Vatarakta. Key parameters such as joint pain, inflammation in joint, tenderness, burning sensation in affected area, skin rashes and tingling sensation were selected for the study. Overall improvement was assessed using standardized tools and patient-reported outcomes. Result: Preliminary findings indicate promising results, suggesting that Amrita Guggulu may play a significant role in alleviating symptoms associated with Vatarakta. The observed effects include a reduction in joint pain, improved joint function, and decreased inflammatory markers. Conclusion: This research contributes valuable insights into the pharmaceutical preparation of Amrita Guggulu and highlights its potential as an effective intervention for Vatarakta. On the basis of this clinical trial, we can say that S. Uric acid is not the confirmatory parameter for the decision of Vatarakta (gout). Further studies and long-term observations are recommended to solidify these findings and establish Amrita Guggulu as a viable therapeutic option in managing inflammatory joint disorders.

A comparative study on the antagonistic effect of an ayurvedic preparation- Kutajarishta and its components on E.coli.

In our study, we examined the effect of kutajarishta and its constituents on five strains of E.coli, one of the causative organisms of colitis. Colitis is an inflammation of colon caused due to micro-organisms like E.coli, Shigella Campylobacter, Salmonella and Yersinia sp. Our study deals with the self-generated herbal fermentation of traditional ayurvedic formulations for colitis the Arishtas and Asavas. They are alcoholic medications prepared by allowing herbal juices or their decoctions to undergo fermentation along with dhataki flowers (Woodfordia fruticosa) and sugars. Dhataki flowers are fermentation initiators. Kutajarishtas also an ayurvedic formulation of Holarrhena sp (kudasaal), Gmelina arborea (Shivan), Woodfordia fruticosa (dhataki flowers), water, raisins and jaggery and can be used to treat colitis. To test the antimicrobial activity of kutajarishta, five strains of E.coli were isolated and confirmed by Indole, Methyl red, Voges-Proskauer and Citrate utilization (IMViC) tests. Alcoholic and aqueous extract of kudasaal and shivan were prepared and the effect of alcoholic and aqueous extract of kutajarishta, kudasaal and shivan were seen against five strains of E.coli by using agar well diffusion method. Further, compound purification from aqueous and alcoholic extract was done by TLC. Kutajarishta is most effective against all the five strains of E. coli as compared to kudasaal and shivan plant extracts. From the study, it can be concluded that the Kudasaal plant extract is more effective than shivan plant extract. Aqueous extracts of kudasaal and shivan are more effective than alcoholic kudasaal and shivan extracts. From the initial screening of all the three extracts we concluded that kutajarishta has maximum antibacterial activity due to the interaction of toxins with the phyto-constituents of the plant.

A Clinical Case Study on Janu Sandhivata (Knee Arthritis) to evaluate the effect of Combined Panchakarma procedure and Internal Traditional Ayurvedic Formulations

Being commonest form of articular disorders Janu Sandhivata (Knee Arthritis) causes a huge hindrance in day to day activities of the sufferer like walking, dressing, bathing etc. It is the disease of old age. It’s mainly effect the weight bearing joint of the body specially knee, hip, lumber spine. As per the Ayurvedic classical references Shula, Sotha, Vata- Poornadriti Sparsha and difficulty in flexion and extension of the Sandhi are the symptoms. There are lots of treatment available in contemporary fields includes NSAID Administration, Intra articular Steroids or eventually surgical intervention in the form of Knee replacement. With this regard there is a need of safe effective and affordable treatment options. In present case study it is tried to explode the Panchakarma procedure like Abhangya, Patra Pinda Shedana therapy, Kashaya Vasti along with few traditional Ayurvedic formulations particularly for Bilateral Knee Osteoarthritis for 30 days duration of treatment it can be concluded that symptoms of severe Osteoarthritis may also be merged with Ayurvedic interventions significantly.

Результати оцінки безпечності для споживачів добавки дієтичної «Тайро Ультра», створеної для підтримки нормальної функції щитоподібної залози

In recent years, Ukraine has seen an increase in consumer interest in dietary supplements made on the basis of traditional Ayurvedic recipes and containing natural organic-mineral complexes. Monitoring their safety for consumer’s health is an urgent task of modern preventive medicine. Aim. Generalization of the results of a comprehensive sanitary and hygienic assessment of the safety for consumers the dietary supplement «Tyro Ultra», created to support the normal function of the thyroid gland. Materials and Мethods. Residual concentrations of pesticides were estimated by the methods of ultra-high-performance highspeed mass spectrometric liquid chromatography with electron spray ionization (Waters, USA) and gas chromatography; the content of heavy metals – by the atomic emission method (Shimadsu ICPE - 9820); content of radionuclides – by spectrometry; investigated microbiological indicators. Results. It has been established that the dietary supplement «Tyro Ultra» meets the requirements of Ukrainian legislation; its chemical and microbiological composition does not pose a threat to the health of consumers, provided that the method and dosage of the dietary supplement are in accordance with the manufacturer's recommendations. According to the review of scientific sources, the components of the «Tyro Ultra» formulation have the potential to normalize metabolism, optimize the chemical composition of the diet, and create optimal dietary conditions to support the normal functioning of the thyroid gland. Conclusions. Assessing the safety of traditional Ayurvedic formulations is an important and at the same time difficult task due to their multi-component composition. Further studies of products made on the basis of traditional recipes will contribute to the expansion of our imagination about means that have the potential of targeted influence on the level of adaptation capabilities of the human body in conditions of negative impact on the environment. Keywords: dietary supplements, sanitary and hygienic assessment, thyroid gland.

Ayurvedic treatment regime of Ovarian Cyst: A Case Report

Introduction: Ovarian cysts are fluid-filled sacs that develop on or within the ovaries, which are part of a woman's reproductive system. Most ovarian cysts are benign (non-cancerous) and do not cause any symptoms. However, in some cases, ovarian cysts can grow larger, rupture, become painful, or cause other complications. Hormonal contraceptives and Surgery only the treatment follow by modern system of medicine. A hormonal contraceptive contributes untoward effect. In Ayurveda it can be correlated with Granthi (Kaphaja Granthi). Methods: In this present case study, a 36 years old woman patient consulted to the OPD with the complaint of Pelvic pain come and go, Bloating in the abdomen, Changes in menstrual patterns, and Pain during sexual intercourse. She had also brought her ultrasonography (USG) and finding suggested a right ovarian complex cyst measuring 36mm×36mmx34mm. She was supposed to be treated with traditional ayurvedic formulations; the case was treated for three months with a combination of different traditional Ayurvedic drugs, with the goal of relieving symptoms and dissolving the ovarian cyst. This patient was treated with traditional Ayurvedic formulations like Varunadi Kashyam, Guggulu Panchapala Churnam, Dashmoola Kwatha, Ajmoodadi Choorna. Result: Only Ayurvedic medicines were used during the course of the treatment. Follow-up USG showed complete disappearance of cyst and symptoms also subsided to a great extent. Discussion: The present study emphasizes the role of Ayurveda in bringing a positive result in the management of ovarian cyst.

In- vitro Antioxidant and Anti-aging activity of a Traditional Ayurvedic Formulation

Aging is an inevitable process for all living organisms. When the skin ages, Reactive Oxygen Species (ROS) are generated, which results in an increase in Hyaluronidase, Collagenase and Elastase, further contributing to skin aging. Amalaki Rasayana (AR) which is a traditional Ayurvedic preparation was investigated to assess its anti-oxidant and anti-aging properties. In order to assess radical scavenging activity, plant extracts/formulations were tested for their ability to scavenge DPPH and nitric oxide radicals. The alcoholic extract was prepared with Amalaki Rasayana (AR) and used for phyto-chemical, anti- oxidant and anti- aging studies. The phyto-chemical screening revealed the presence of tannins, alkaloids and flavonoids. The in- vitro anti- oxidant activity of Amlaki Rasayana (AR) was carried out by DPPH and Nitric oxide radical scavenging assay method. The DPPH assay revealed the concentration dependent scavenging activity with the extract and the results are comparable with standard quercetin. The percentage inhibition was more at 1000 μg/ml of the ethanol extract in Nitric oxide scavenging assay. The in- vitro anti- aging potential was evaluated by anti- collagenase assay method using FALGPA as substrate. The ethanol extract exhibited significant inhibition on collagenase enzyme which was comparable to standard EDTA. The ethanol extract of Amlaki Rasayana (AR) showed significant anti- oxidant and anti- aging activity which may be attributed to phyto- constituents such as flavonoids, alkaloids and tannins. This study offers scientific validation of Amlaki Rasayana (AR) for anti- aging activity and can be recommended to be taken internally for aging problems.

COMPARATIVE PHYSICOCHEMICAL EVALUATION OF ASHWAGANDHARISTA FORMULATIONS: TRADITIONAL VS. MODERN METHODS

Ashwagandharista, a traditional Ayurvedic formulation, is prepared using traditional and modern methods. This study aims to compare the physicochemical properties of Ashwagandharista formulations prepared by traditional and modern methods. Samples were collected from both traditional and modern manufacturing units. Physicochemical parameters such as pH, density, viscosity, total solid content, and ash value were evaluated according to standard procedures. The results revealed significant differences in various physicochemical parameters between the traditional and modern formulations of Ashwagandharista. The findings suggest that the manufacturing method significantly influences the physicochemical properties of Ashwagandharista formulations.

SAMYAK PRAYOGAM SARVESHAM SIDDHIRAKHYATI KARMANAM WSR TO PUSHYANUGA CHURNA

Ayurveda is an ancient health science that helps in the eradication of diseases as well as maintaining the health of a healthy person. The main purpose of it is to maintain the health of healthy individuals and cure the disease of diseased ones. There are a number of classical formulations successfully practiced by Ayurveda physicians for treating various ailments. One such multidrug classical formulation is Pushyanuga Churna which is a widely practiced Ayurveda formulation. Pushyanuga Churna is a traditional Ayurvedic formulation prescribed for the treatment of various female reproductive disorders like Swetapradara, Asrigdara, U.T.I., etc.

Ameliorating effect of polyherbal formulation (Febrojith) on acute and chronic inflammatory model via inhibiting inflammation and oxidative stress

Ethnopharmacological relevanceInflammation is a complex biological response of the tissue to noxious stimuli, which causes several debilitating inflammatory disorders. Currently, various conventional medicines are available, but their consumption causes adverse effects, hence researchers focused on alternatives like medical herbs from natural sources, as one of the most promising sources of therapeutic agents for inflammation. Febrojith is a well-known traditional Ayurvedic formulation obtained from the treasures of Ayurveda with a unique blend of herbs that are used effectively in preventing and combating a broad spectrum of infections, fevers, and also enhancing immunity for many years. However, its anti-inflammatory, efficacy and underlying mechanism remained unexplored. Aim of the studyIn the present study, we investigated the chemical characterization and in vivo anti-inflammatory efficacy of Febrojith (FB) on acute and chronic inflammatory models via inhibiting inflammation and oxidative stress. Materials and methodsFB was analyzed for chemical characterization & its phytoconstituents by UV–Vis spectrum, FT-IR, and GC-MS analysis. The anti-inflammatory activity of FB was studied on carrageenan-induced acute and adjuvant-induced chronic experimental models. The inflammatory cytokines and mediators were measured using the ELISA & Colorimetry techniques. Histopathology and cytology of paw tissue and synovium were analyzed by H&E and Papanicolau's (PAP)-staining methods. Results100 mg/kg bwt was found to be a potent dose from the carrageenan model and evaluated its effect in the adjuvant-induced chronic arthritic model. In the chronic model, 84% of edema inhibition was observed at the dose of 100 mg/kg bwt. Moreover, the supplementation of FB was shown to significantly (p ≤ 0.05) decrease the TBARS level and activity of myeloperoxidase in the paw tissue. In addition, adjuvant-induced production of various pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, PGE2, NO and COX-2 were suppressed in inflamed rats subjected to FB supplementation. It also revealed that FB supplementation significantly (p ≤ 0.05) reduced the haematological markers. From the histopathology and cytological analysis, we found a reduction in the edema formation, and infiltration of inflammatory cells after the supplementation of FB. ConclusionIn conclusion, FB might be used as an effective and potent drug against inflammation.

Traditional Ayurvedic Formulation in the Management of COVID-19

Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that belongs to the coronavirus family. The first case was reported in December 2019, and the disease has become a pandemic. Impaired immune regulation is one of the factors that play a role in its pathogenesis and results in poor outcomes of COVID-19 patients. There have been many studies with drug candidates used as antivirals or immunomodulators. However, the results of these investigations showed that the drug candidates were not significantly effective against the disease. Meanwhile, people believe that consuming herbal immunomodulators can prevent or even cure COVID-19. Unfortunately, specific preclinical and clinical trials to evaluate the effects of herbal immunoregulators have not been conducted. Certain natural compounds might be effective for the treatment of COVID-19 based on general concepts from previous experiments. This review discusses some herbal agents extracted from various plants, including Curcuma longa, Cinchona, Ashwagandh aand Lianhuaqingwen, which are considered for the treatment of COVID-19. In addition, we discuss the pros and cons of utilising herbal medicine during the COVID-19 pandemic, draw some conclusions, and make recommendations at the end of the session.

Role of Ayurveda in Trichomonas Vaginitis- A Case Report.

Health of a woman plays a very important role in family which reflects on society too. Most women suffer with vaginal infection; among them Trichomonas vaginitis is very common. Though it is projected to be 40 to 50% in the age group of childbearing women, the incidence of trichomonas infection is about 10-15%. The inflammation and itching at the site of the vulva and vagina indicate the sign of probably of trichomonas vaginitis. Methodology: In this present case study, Patient age 47 year came to OPD with complaint of pain lower abdomen off and on since 2 yrs , pt had no other symptom . On basis of these complaints along with P/A examination, P/V and P/S examination have been done, which reveals trichomonas infection. She was supposed to be treated with traditional ayurvedic formulations; the case was treated for 7 days with a combination of different traditional Ayurvedic drugs, and sthanik chikitsa with the goal of relieving symptoms and curing the disease. This patient was treated with traditional Ayurvedic formulations like Triphala Guggulu, Chandraprabha Vati, Gandhak Rasayana, Sthanik Chikitsa - Yoni Dhawana (Vaginal douche) with Panchvalkala Kwatha followed by Yoni Pichu with Jatyadi Taila once in a day for 7 days. Result: Only traditional Ayurvedic medicines were used during the course of the treatment. Follow-up showed complete disappearance of strawberry appearance of cervix and symptoms also subsided to a great extent. Discussion: The present study emphasizes the role of Ayurveda in bringing a positive result in the management of Trichomonas vaginitis

Review on Artocarpus nobilis Thw. (Moraceae): An Endemic Plant of Sri Lanka

The genus Artocarpus consists of about 50 species of large evergreen trees with various medicinal and economical uses. Artocarpus nobilis (Family: Moraceae) is commonly referred to as Ceylon breadfruit and it is endemic to Sri Lanka. Synonyms of A. nobilis are Artocarpus imperialis André, Artocarpus pubescens Moon and Saccus nobilis (Thwaites) Kuntze. Extracts from leaves, bark, fruits and latex are rich in phytochemical compounds such as flavanones, flavonoids, triterpenoids, xanthones, stilbenes and chalcones. These bioactive compounds contribute to various pharmacological properties of Ceylon breadfruit (Artocarpus nobilis). It is used in Ayurvedic and folk medicine to treat asthma, diarrhea, worm infestations and wound healing. It also used in traditional ayurvedic formulations like Chandana guli wattoruwa. Several research that has been carried out on this plant include the evaluation of antibacterial activity, anti-inflammatory activity, antioxidant, antifungal, biosorption and Glutathione-S transferase inhibitory activities. Apart from these it is a productive source of edible fruit and yield good timber. A combination of traditional and new technologies will be important in the future to develop therapeutic products from Artocarpus nobilis. In this present review, attempts on providing comprehensive information on research conducted on A. nobilis.