The availability of medicines, their quality, efficacy and safety in Ukraine are recognized as the COVID-19 pandemic and Russian armed aggression, the provision of medicines to the population and increasing their availability in Ukraine are becoming integral components of the state healthcare policy aimed at creating a patient-centered system, as implemented in developed European countries. E-commerce of medicines has become one of the new activities of pharmacies. As Ukraine has a large medical market and rapid digital development, e-pharmacies are becoming increasingly accessible and popular among customers. Electronic commerce in medicines (e-pharmacy) is a pharmacy that fulfills a consumer's order placed via the Internet. Despite the obvious convenience, strict regulation of activities and sufficient legislative basis, the procedural stages of selling medicines remotely remain unregulated. The main advantages of e-commerce of medicinal products in Ukraine include convenience and accessibility, a wide range of products, nationwide delivery, and expert advice. At the same time, the organizational and legal regulation of electronic trade in medicinal products in Ukraine does not regulate all the specifics of such trade, which could potentially threaten public health and safety. Further regulation is required for the delivery of prescription medicines; quality assurance of medicines; protection of the end user from violation of the rules for the sale and delivery of medicines, as well as from counterfeit and fake medicines; regulation of the issue of bringing a person to legal liability for violation of the rules for the sale and delivery of medicines; regulation of the issue of peculiarities of the use of payment transaction registers during the delivery of medicines.