The West African sub-region bore the brunt of the world's largest Ebola outbreak, significantly impacting the economic activities and trade shares of the affected countries. This study seeks to examine the repercussions of the Ebola Virus Disease (EVD) on the trade shares of affected countries and to explore the potential influence of ECOWAS membership on intra-regional trade in West Africa. Using the Poison Pseudo Maximum Likelihood (PPML) estimation technique, an analysis of the augmented gravity model of international trade was conducted. The findings indicate a two-fold reduction in the trade shares of affected countries with their intra-regional partners due to the Ebola Virus Disease. Additionally, with Mauritania expressing its desire to join the ECOWAS sub-region, there is a need to explore the impact of the Regional Economic Community on intra-regional trade. Furthermore, the study reveals that ECOWAS membership has the potential to double trade levels in West Africa. The findings also suggest that Mauritania stands to gain significant benefits from becoming a member of the ECOWAS. In conclusion, this study highlights the necessity for ECOWAS to proactively respond to disease outbreaks and underscores the importance of increased research investment. Moreover, it emphasizes the need for the ECOWAS to further improve infrastructure to facilitate intra-regional trade, especially in transportation.