Trade Center Research Articles

Cross-sectional association between posttraumatic stress and cognition is moderated by pulmonary functioning in world trade center responders.

Posttraumatic stress disorder (PTSD) symptomatology and poorer pulmonary function are highly prevalent psychiatric and medical conditions. In the present study, we tested for the individual, additive, and modifying associations of PTSD symptomatology and pulmonary function with cognitive performance. In this cross-sectional study, a total of 1,401 World Trade Center (WTC) responders (mean age = 53, SD = 8 years, 92% males) participated in the study. Cogstate assessment measured cognitive performance. PTSD symptomatology was measured using the trauma-specific version of the posttraumatic stress disorder checklist (PCL-17) adapted for the WTC attacks. The 1-second forced expiratory volume and forced vital capacity (FEV1/FVC) ratio was used to measure pulmonary function. Linear regressions with cognitive performance as the outcome were conducted to assess individual, additive, and moderating associations of PTSD symptomatology and pulmonary function. Higher PTSD symptomatology and poorer pulmonary function were negatively associated with cognitive performance. A 10% increase on the FEV1/FVC ratio moderated the association between PTSD symptomatology and cognition, whereby its association with cognition was stronger when PTSD symptomatology was higher (est. = 0.01, 95%CI = 0.004, 0.01, p < 0.001). When stratified by responder type, these associations persisted in trained (est. = 0.01, 95%CI = 0.01, 0.02, p < 0.001), but not in non-trained (est. = 0.004, 95% C.I. = -0.01, 0.02, p = 0.39) responders. In the presence of higher PTSD, better pulmonary functioning is associated with better cognitive performance. Early intervention efforts to mitigate preventable cognitive decline in high-risk populations should be studied, especially since intervention in one modality may have an impact on others.

On the integration of multiple criteria decision aiding and forecasting: Does it create value in portfolio selection?

A systemic integration of multiple criteria decision aiding (MCDA) and forecasting is presented for enhancing the quality of investment decisions. First, we provide a new methodological approach for combining forward-looking information, as an input to further MCDA analysis and we illustrate that the informational content of the MCDA scores is distinct from that of the original data used as input to the MCDA. Moreover, we provide very compelling evidence that the produced MCDA scores and rankings have incremental information, over and above that being contained in either the original data or the forecasts themselves. Therefore, it can be used successfully in providing methods which will have a high, a priori, chance of resulting in financial performance enhancements; to this end, we have illustrated this finding with a number of different approaches, including asset rotation and portfolio construction. Next, we show that the MCDA ranked variables can be used for both in-sample explaining and out-of-sample forecasting of critical economic variables, such as the real GDP growth or the unemployment rate, so that MCDA might be able to assist in identifying leading indicator properties for economic forecasting. The evaluation of the suggested approach entails extensive empirical testing on the various US economy market sectors, as expressed by the corresponding S&P 500 Exchange Traded Funds (ETFs), for a period of 22 years, documenting specific economic stylized facts, reported for first time in the relevant literature.

Репрезентативность показателей и объективность оценок в компаративистике: экономика Российской империи второй половины XIX столетия в современных зарубежных исследованиях

The relevance of comparative studies of the level of industrial and economic development of the Russian Empire in the second half of the XIX century is determined by the fact that their results in some cases are used to substantiate theoretical ideas about the national characteristics of the Russian economy and society in comparison with the leading countries of Industrial Revolution. In economic literature, assertions about the “catastrophic” backwardness of Russia during this period are often encountered. Modern foreign historical-economic research allows for a more objective assessment of the gap between the level of industrial and economic development of the Russian Empire and the “advanced” states. However, the authors of these studies do not always succeed in consistently applying the principle of uniform criteria for comparing different economies. In particular, it is hardly justified: in some cases, to take into account, and in others, not to take into account the population and economic potential of territorial isolated peripheral regions of the respective economies. For example, the value of historical and economic comparisons is reduced by the confusion in research between the actual territory of the Russian Empire in the middle and second half of the XIX century, its territory within the conditional “borders of 1913” and the territory within “former USSR” borders. In this regard the article notes that conclusions drawn on the basis of fragmentary and arbitrarily interpreted information can’t be considered as fully correct. According to the author, in a comparative analysis of the economies-leaders of the Industrial Revolution, it is necessary to use assessment methods that take into account the population and indicators of economic development of peripheral territories were included in trade and financial exchanges with these economies, because this inclusion strongly spired the development of economies-leaders.

The Influence of Financial Inclusion on Stock Market Participation in Nepal: Exploring the Mediating Effect of Financial Knowledge

This paper focuses on financial inclusion (FI), a fast-embracing topic with potential drivers of economic growth and the improvement of individual financial well-being. This study contributes to the existing literature by analysing how financial inclusion influences stock market participation (SMP) in Nepal, explicitly emphasising the intermediary role of economic knowledge. The study employed a causal-comparative research design, and the data were collected from 403 individual investors actively participating in the Nepal Stock Exchange (NEPSE) trading. The statistical tools used to meet the objectives of this research are descriptive statistics, factor analysis, and structure equation modelling. The study results show that FI and knowledge influence individual investor participation in the stock market. The result also indicates that FI is positively related to stock market activity, while it is essential to enhance citizens' FK significantly. Further, mediation analysis shows that FK partially mediates the relationship between FI and SMP. This suggests its pivotal role in narrowing the gap between access to financial services and actual investment behaviour. These findings underscore the critical role of FI in creating an inclusive and participatory financial ecosystem within Nepal. Longitudinal data in future research can capture the evolving dynamics of FI and its long-term impact on SMP.

Analysis of Problems and Countermeasures in Chinese Stock Market

Chinas stock is one of the most popular trading platforms with high global attention, it plays an important role in Chinese economy and global economy. With the rapid development of Chinese economy, Chinas stock market has also achieved significant achievements. It not only provides a vital platform to finance, but also optimize resource allocation. Whats more, it decreases the investors risk of the investment, and makes it is possible for government to carry out macro-economic policies through market stock. it boosts the development of Chinas financial system, and increases the ability of the Chinas financial system to anti-risks. However, there are also some problems existing in Chinese stock market, for example, the less reasonable structure of investors, serious disadvantages in the small and medium-sized GEM market governance, and frequent problems occur in the stock market trading mechanism and exchange system. This paper will as these three problems basis of starting the topic, and put forward countermeasures and strategies, which will have significant role in solving the existing problems efficiently in Chinese stock market.

Teaching the art of compassionate inquiry: involving survivors from 9/11 in social work education

ABSTRACT This paper reports findings from pedagogic research evaluating the impact of the involvement of survivors from the World Trade Center attacks in New York City in 2001 in trauma-specific social work education. A pedagogic approach to mental health education is discussed which aims to prepare students to develop trauma-informed assessment and intervention skills concurrent with their encounters with trauma survivors in field practice placements. The small-scale research involved surveying students’ evaluations at a university in New York, following exposure to first-hand accounts of survivors’ experiences. Across the three areas—confidence in knowledge of trauma, impact on learning, and preparation for field practice—the evaluation findings indicate that the students’ knowledge, gained from the involvement of 9/11 survivors, improved over time. This paper presents the background to this project, preparations involved, and findings from research evaluations with the students. The findings suggest that the involvement of those with direct and lived trauma experience in classroom teaching, whilst challenging, can yield positive impacts for students. The 9/11 survivors poignantly shared with students that their lives were changed forever in the aftermath of these events. The findings have potential global educational impact and resonance.

VOC dan Dinamika Kekuasaan di Sumenep Abad XVIII

The city of Sumenep is a traditional palace city which is located on the outskirts of the city and also close to the beach. The Palace City has the function of being the residence of kings and their families, and has a role as a place for cultural activities, government activities and the economy. Since 1705, after Sumenep came under the auspices of the VOC, elements of foreign culture began to enter into the formation of the city of Sumenep. The general aim of this research is to describe incidents or events in the past, and then use them for the learning process in the present. The research method used in this research is the historical research method which consists of five stages, first topic selection, second heuristics, third source criticism, fourth interpretation, and fifth historiography. Sumenep is located at the tip of Madura Island and occupies a strategic position that supports Sumenep as a stopping area which is often visited by ships and boats from the archipelago or from abroad. In 1705, when Mataram entered into an agreement, Sumenep as a whole became colonial territory and Sumenep was a busy trade center in the 18th century because it had a port as a stopping area for ships connecting with islands in the eastern region and had an important port for trade over long distances. Thus, the release of the Sumenep area from Mataram's control would certainly go through a long process. One of the influencing factors is the existence of an element of interest in maintaining the power that has mastered this issue.

Assessing the Competitive Advantage of Ecuador’s Shrimp Industry in the Global Market Using the Balassa Index for 2018–2022

Increased shrimp production in Ecuador might significantly boost the nation’s economic development while allowing for the sustainable exploitation of its natural resources. Business owners in Ecuador still require diagnostic tools for investment, marketing, and production planning. Therefore, this study aimed to evaluate the competitive position of Ecuador’s shrimp industry and direct competitors in the global shrimp market. Export data on shrimp from the International Trade Centre and Ecuador’s National Chamber of Aquaculture were used for the top five shrimp-exporting countries. The period 2018–2022 was chosen as the information was available at the start of the research. Balassa’s methodology was employed for the competitiveness analysis, and statistical analysis was conducted to validate the findings. The results show Ecuador has a significant competitive edge compared to its main rivals, Argentina, India, Indonesia, and Vietnam. This analysis indicates that Ecuador has the potential to win bigger market shares in the global shrimp trade despite being placed 70th and 97th, respectively, in the 2017–2018 Global Competitiveness Index and the 2018 Logistics Performance Index. Therefore, it is necessary to establish strategic production plans for Ecuadorian shrimp enterprises to adapt to the global shrimp trade demands and to advance production and supply chain technology so that Ecuador can access additional worldwide markets.

Exposure to the World Trade Center Particulate Matter Alters the Gut-Brain Axis in Early Onset Alzheimer's Disease Mice.

The September 11, 2001, catastrophe unleashed widespread destruction beyond the World Center (WTC), with fires and toxic gases leaving lasting impacts. First responders at Ground Zero faced prolonged exposure to hazardous particulate matter (PM), resulting in chronic health challenges. Among the multitude of health concerns, the potential association between the WTCPM and Alzheimer's disease (AD) has emerged as an area of intense inquiry, probing the intricate interplay between environmental factors and neurodegenerative diseases. We posit that a genetic predisposition to AD in mice results in dysregulation of the gut-brain axis following chronic exposure to WTCPM. This, in turn, may heighten the risk of AD-like symptoms in these individuals. 3xTg-AD and WT mice were intranasally administered with WTCPM collected at Ground Zero within 72 hours after the attacks. Working memory and learning and recognition memory were monitored for 4 months. Moreover, brain transcriptomic analysis and gut barrier permeability along with microbiome composition were examined. Our findings underscore the deleterious effects of WTCPM on cognitive function, as well as notable alterations in brain genes associated with synaptic plasticity, pro-survival, and inflammatory signaling pathways. Complementary, chronic exposure to the WTCPM led to increased gut permeability in AD mice and altered bacteria composition and expression of functional pathways in the gut. Our results hint at a complex interplay between gut and brain axis, suggesting potential mechanisms through which WTCPM exposure may exacerbate cognitive decline. Identifying these pathways offers opportunities for tailored interventions to alleviate neurological effects among first responders.

World Trade Center (wtc) related exposures and cardiometabolic risk among the wtc Health Program General Responder Cohort

World Trade Center (wtc) related exposures and cardiometabolic risk among the wtc Health Program General Responder Cohort

Long-term reorganization of structural and functional connectivity among World Trade Center responders with post-traumatic stress disorder: a data-driven multimodal approach

Long-term reorganization of structural and functional connectivity among World Trade Center responders with post-traumatic stress disorder: a data-driven multimodal approach

Analysis of GDP Between China and the United States

The GDP of China and the United States is one of the two largest economies in the world, and both countries play a crucial role in the global economy. The impact of their GDP growth on the global economy is also increasing. By analyzing the GDP of China and the United States, we can understand the development trends and characteristics of the two countries' economies, thereby providing reference and reference for the global economy. China and the United States are one of the world's largest trading countries, and their trade relations have a significant impact on the global economy. By analyzing the GDP of China and the United States, we can understand the trade exchanges and structure between the two countries, thereby providing reference for solving trade problems. China and the United States play an important role in global political stability. By analyzing the GDP of China and the United States, we can understand their status and influence in international politics, thereby providing support for maintaining global political stability. China's economic growth is getting faster and faster, gradually gaining a significant position globally. This article adopts a detrend approach to analyze GDP, discuss the economic conditions and possible future trends of China and the United States.

THE DYNAMICS OF EXCHANGE RATES, INFLATION, AND TRADE BALANCE IN A SMALL OPEN ECONOMY (CASE STUDY OF SIERRA LEONE)

Sierra Leone experiences a persistent trade deficit problem. Currently, there is a vacuum in the literature employing recent data and suitable approaches to address the issue of non-stationarity and dynamic interaction between macroeconomic variables in influencing the trade deficit in Sierra Leone. This study examines the relationship between Sierra Leone's trade balance, inflation, and exchange rate using quarterly data from 2005 Q1 to 2023 Q3. The focus is on understanding how the exchange rate and inflation impact Sierra Leone's trade balance in both the short and long term. To achieve this, the study utilizes the VAR/VECM model to depict the dynamic interaction between the trade balance, exchange rate, and inflation. It also employs Granger Causality analysis to determine the most appropriate ordering among the macroeconomic variables in the model and Impulse Response Function (IRF) analysis to test the hypotheses regarding the trade balance response to exchange rate shocks and inflation. The empirical results confirm the existence of cointegration, indicating a long-term balance between the trade balance, exchange rate, inflation, and other macroeconomic variables such as GDP growth and interest rate differentials. Moreover, the dynamic prediction analysis using the IRF method supports the J-curve hypothesis in Sierra Leone and suggests that inflation can reduce the performance of the trade balance. These findings highlight the need for Sierra Leone to implement a comprehensive strategy to adjust the exchange rate and curb inflation to improve the trade balance and enhance external economic stability.

Strategi Berinvestasi terhadap Keberhasilan Investasi Saham Syariah di Pasar Modal Syariah

Stocks and the Indonesian capital market coexisted in Indonesia in 1912, when the Indonesian capital market was first established. An Islamic regulation master named Abdurrahman Isa contends that stock trading exchanges are permitted in religion, including shares gave by banking organizations, where a portion of the exercises are revenue based credit. This is based on the circumstances of Muslims, who, in his opinion, are in a dhorurat state. This study made use of literature research, which uses information from books and other sources to investigate the method for putting into practice investment in sharia stocks as a tool for economic improvement. The English word investment, which means to plant, was adopted from the British language. According to the Dictionary of Capital Market and Financial Terms, "investment" refers to putting money or capital into a business with the intention of earning a profit. The Capital Market Law regulates the sharia capital market, which is a capital market that does not violate sharia law. In this instance, the Capital Market and Financial Institutions Supervisory Agency (Bapepam-LK) continues to oversee the sharia capital market. The fundamental difference between the sharia capital market and the conventional capital market is that the sharia capital market must adhere to sharia law in all transaction mechanisms and issuers traded in it. In other words, there is no significant difference between the two markets.

General characteristics of investment law in India

The aim of the work is a comprehensive analysis of investment law in India. The methodological basis of the study are official websites of specialized institutions, laws, analytical reports, articles by other scientists, etc. According to the results of the conducted research, it was found that two main legislative acts regulate investment activities in India. The first piece of legislation is the Foreign Exchange Management Act, 1999, the main objective of which is to promote foreign trade and foreign exchange and to develop and maintain the foreign exchange market in India. According to Section 5 and 6 of the Law, operations with a current currency account are allowed only on the condition that they do not have any restrictions (criminal, state, etc.). Capital account transactions mean transactions during which changes in assets or liabilities occur (referring to liabilities of resident and non-resident persons in relation to assets). The second act – Consolidated Policy on Attracting FDI in India by the Department of Trade and Industry Promotion 2020 – includes clarification of all investment norms. The policy update is in line with the policy of need to attract FDI to India, as per the plans of the Department. In conclusion, it was found that the legal system of India is based on common law, which is based on English law. According to the Constitution of India, a quasi-federal structure has been approved, which provides for the division of legislative power between the central government and the individual states. Foreign direct investment in India is governed by two main pieces of legislation. The first is the Foreign Exchange Management Act of 1999, its main objective is to facilitate foreign trade and foreign exchange and to develop and maintain the Indian foreign exchange market. The second – Consolidated policy on attracting FDI to India. Attracting foreign direct investment in India is possible in two ways: automatic investment of FDI and obtaining permission for FDI.

CPTPP Intellectual Property Rules and China's Response

In the complex and changeable international environment, due to the serious crisis of the multilateral trading system of the World Trade Organization and the influence of trade protectionism of Western countries, the United States and other developed countries try to promote trade facilitation through institutional changes and innovations in the field of intellectual property in order to seek more benefits. In order to avoid being marginalized in the reconstruction of international economic and trade rules and affecting trade exchanges between China and other countries, China formally submitted a written application to join the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) in 2021. The CPTPP, which came into effect in 2018, covers a wide range of content, comprehensive and high standards. So far, the issue of intellectual property is still one of the most important issues that some countries want to solve if they want to join the CPTPP. Although CPTPP shelve the 11 high-standard provisions in TPP, there is still a certain gap between China's intellectual property legal system and the CPTPP intellectual property rules at present. In order to successfully connect with the CPTPP intellectual property rules, it is necessary for China to conduct a comprehensive investigation of its intellectual property text and analyze the differences between it and the domestic intellectual property legal system. And put forward countermeasures.

Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN) in World Trade Center exposed firefighters: a case–control observational study protocol

BackgroundParticulate matter exposure (PM) is a cause of aerodigestive disease globally. The destruction of the World Trade Center (WTC) exposed first responders and inhabitants of New York City to WTC-PM and caused obstructive airways disease (OAD), gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE). GERD not only diminishes health-related quality of life but also gives rise to complications that extend beyond the scope of BE. GERD can incite or exacerbate allergies, sinusitis, bronchitis, and asthma. Disease features of the aerodigestive axis can overlap, often necessitating more invasive diagnostic testing and treatment modalities. This presents a need to develop novel non-invasive biomarkers of GERD, BE, airway hyperreactivity (AHR), treatment efficacy, and severity of symptoms.MethodsOur observational case-cohort study will leverage the longitudinally phenotyped Fire Department of New York (FDNY)-WTC exposed cohort to identify Biomarkers of Airway Disease, Barrett’s and Underdiagnosed Reflux Noninvasively (BAD-BURN). Our study population consists of n = 4,192 individuals from which we have randomly selected a sub-cohort control group (n = 837). We will then recruit subgroups of i. AHR only ii. GERD only iii. BE iv. GERD/BE and AHR overlap or v. No GERD or AHR, from the sub-cohort control group. We will then phenotype and examine non-invasive biomarkers of these subgroups to identify under-diagnosis and/or treatment efficacy. The findings may further contribute to the development of future biologically plausible therapies, ultimately enhance patient care and quality of life.DiscussionAlthough many studies have suggested interdependence between airway and digestive diseases, the causative factors and specific mechanisms remain unclear. The detection of the disease is further complicated by the invasiveness of conventional GERD diagnosis procedures and the limited availability of disease-specific biomarkers. The management of reflux is important, as it directly increases risk of cancer and negatively impacts quality of life. Therefore, it is vital to develop novel noninvasive disease markers that can effectively phenotype, facilitate early diagnosis of premalignant disease and identify potential therapeutic targets to improve patient care.Trial registrationName of Primary Registry: “Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)”. Trial Identifying Number: NCT05216133. Date of Registration: January 31, 2022.

Sleep disturbances across two weeks predict future mental healthcare utilization.

Insufficient sleep costs the U.S. economy over $411 billion per year. However, most studies investigating economic costs of sleep rely on one-time measures of sleep, which may be prone to recall bias and cannot capture variability in sleep. To address these gaps, we examined how sleep metrics captured from daily sleep diaries predicted medical expenditures. Participants were 391 World Trade Center responders enrolled in the World Trade Center Health Program (mean age = 54.97 years, 89% men). At baseline, participants completed 14 days of self-reported sleep and stress measures. Mean sleep, variability in sleep, and a novel measure of sleep reactivity (i.e., how much people's sleep changes in response to daily stress) were used to predict the subsequent year's medical expenditures, covarying for age, race/ethnicity, sex, medical diagnoses, and body mass index. Mean sleep efficiency did not predict mental healthcare utilization. However, greater sleep efficiency reactivity to stress (b=$191.75, p=.027), sleep duration reactivity to stress (b=$206.33, p=.040), variability in sleep efficiency (b=$339.33, p=.002), variability in sleep duration (b=$260.87, p=.004), and quadratic mean sleep duration (b=$182.37, p=.001) all predicted greater mental healthcare expenditures. Together, these sleep variables explained 12% of the unique variance in mental healthcare expenditures. No sleep variables were significantly associated with physical healthcare expenditures. People with more irregular sleep, more sleep reactivity, and either short or long sleep engage in more mental healthcare utilization. It may be important to address these individuals' sleep problems to improve mental health and reduce healthcare costs.

Sky Is the Limit: Examining the Evolution of Indo-Israel Defence Relations

The symbiotic relationship between India and Israel is underpinned by their parallel experiences following the tumultuous partition. The steadfast adherence to democratic principles, joint efforts to counter belligerent neighboring states, and the mounting specter of transnational terrorism have further cemented their bond. This research paper delves into the evolution of India&amp;apos;s diplomatic entente with Israel. Geopolitically, the two nations have collaborated in counterterrorism, defense, intelligence coordination, research, and advancements in the scientific and technological domains. Their bilateral cooperation has extended to encompass agriculture, water resource management, trade, tourism, and cultural exchange, consequently bolstering their strategic partnership for mutual benefit. This paper scrutinizes the intricate strategic alignment forged between India and Israel in 1992, which marked the conclusion of a protracted diplomatic estrangement spanning over four decades subsequent to their declarations of independence. It principally focuses on their concerted endeavors in counterterrorism, encompassing initiatives such as mutual information sharing, implementation of counterterrorism strategies, amplification of telecommunications infrastructure, and fortification of internet networks. The study supplies a comprehensive scrutiny of the multifaceted challenges confronting India in combatting terrorist threats within its borders, taking into consideration both international dynamics and domestic political barriers that influence the country&amp;apos;s collaborative pursuits with Israel. Moreover, it meticulously evaluates the catalytic role of the Narendra Modi administration in strengthening the defense alliance between the two nations.

Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency Responders.

The emergency personnel who responded to the World Trade Center (WTC) attacks endured severe occupational exposures, yet the prevalence of cognitive impairment remains unknown among WTC-exposed-FDNY-responders. The present study screened for mild and severe cognitive impairment in WTC-exposed FDNY responders using objective tests, compared prevalence rates to a cohort of non-FDNY WTC-exposed responders, and descriptively to meta-analytic estimates of MCI from global, community, and clinical populations. A sample of WTC-exposed-FDNY responders (n = 343) was recruited to complete an extensive battery of cognitive, psychological, and physical tests. The prevalences of domain-specific impairments were estimated based on the results of norm-referenced tests, and the Montreal Cognitive Assessment (MoCA), Jak/Bondi criteria, Petersen criteria, and the National Institute on Aging and Alzheimer's Association (NIA-AA) criteria were used to diagnose MCI. NIA-AA criteria were also used to diagnose severe cognitive impairment. Generalized linear models were used to compare prevalence estimates of cognitive impairment to a large sample of WTC-exposed-non-FDNY responders from the General Responder Cohort (GRC; n = 7102) who completed the MoCA during a similar time frame. Among FDNY responders under 65 years, the unadjusted prevalence of MCI varied from 52.57% to 71.37% depending on the operational definition of MCI, apart from using a conservative cut-off applied to MoCA total scores (18 < MoCA < 23), which yielded a markedly lower crude prevalence (24.31%) compared to alternative criteria. The prevalence of MCI was higher among WTC-exposed-FDNY-responders, compared to WTC-exposed-non-FDNY-GRC-responders (adjusted RR = 1.53, 95% C.I. = [1.24, 1.88], p < .001) and meta-analytic estimates from different global, community, and clinical populations. Following NIA-AA diagnostic guidelines, 4.96% of WTC-exposed-FDNY-responders met the criteria for severe impairments (95% CI = [2.91% to 7.82%]), a prevalence that remained largely unchanged after excluding responders over the age of 65 years. There is a high prevalence of mild and severe cognitive impairment among WTC-responders highlighting the putative role of occupational/environmental and disaster-related exposures in the etiology of accelerated cognitive decline.