Image registration has become one of the most widely used techniques in computer vision. Its applications include optical flow, notion analysis, tracking, face detection, and biomedical image registration. In the present work, three different techniques of image registration were implemented and applied to both Computed Tomography (CT) and Magnetic Resonance (MR) images. The first technique is based on Cross Correlation (CC). The second approach depends on Control Points' Selection (CPS) from both the reference and the input images. The last technique is based on Maximization of Mutual Information (MMI) between We two images. The registrability is calculated for each image to measure its ability to provide unambiguous registration, by providing clear correlation peaks when registered with other subimage. Then, the three registration techniques were evaluated and compared using both the Weighted Peak Signal to Noise Ratio (WPSNR) and the Normalized Cross Correlation Coefficient (NCCC). The application of the selected techniques to CT and MR images has shown that registration based on MMI has given the best results and can be used efficiently for alignment of CT and MR images.
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