AbstractThis paper addresses the trajectory tracking problem for a class of uncertain manipulator systems under the effect of external disturbances. The main challenges lie in the input constraints and the lack of measurements of joint velocities. An extend‐state‐observer is utilized to estimate the velocity signals; then, a neural‐network‐based adaptive controller is proposed to solve the problem, where a term based on the nominal model is included to enhance the tracking ability, and the effect of uncertainties and disturbances are compensated by a neural‐network term. Compared with the existing methods, the main distinctive features of the presented approach are: (i) The control law is guaranteed to be bounded by design, instead of directly bounded by a saturation function. (ii) The trade‐off between the performance and robustness of the presented controller can be easily tuned by a parameter that depends on the size of model uncertainties and external disturbances. By virtue of the Lyapunov theorem, the convergence properties of the proposed controller are rigorously proved. The performance of the controller is validated via both simulations and experiments conducted on a two‐degree‐of‐freedom robot manipulator.