Rail wear is one of the phenomena caused by rolling contact of rail and wheel. Situation of rail wear changes with complexity because the contact of rail and wheel changes gradually according to the running condition of vehicles and track geometry condition. Therefore, it is important to predict the wear profile of rail continuously. However, predicting the change of rail profile due to wear has been mostly examined based on one contact condition of rail and wheel. SIMPACK, which is one of the Multi-Body Dynamics (MBD) software is very useful to analyze vehicle dynamics, contact conditions of rail and wheel and so on. In this research, the authors constructed a model for predicting of worn profile of rail incorporated in SIMPACK and carried out the analysis under the several conditions. Furthermore, we examined about the influential factor of wear of rail.