Objective To investigate the first decompression time of TR Band hemostasis after transradial percutaneous coronary intervention (TRI), provide evidence to support and guidance for clinical nursing practice. Methods By searching Cochrane Library, OVID, PubMed, Chinese biomedical literature service system (CBM),China National Knowledge Infrastructure (CNKI), VIP database (VIP), Wanfang database, the randomized controlled trials (RCTs),controlled clinical trials (CCT)and historical cohort study (HCT)of TR Band hemostasis after coronary artery intervention were collected and analyzed. Two reviewers used bias risk assessment tool according to Cochrane recommendation Handbook 5.0 to evaluate, Meta-analysis was carried out using RevMan 5.1.5 software. Results A total of 1 881 patients in 2 RCTs and 3 CCTs were included. Compared with the first decompression time 30 min, patients in 1 h group with limb swelling and pain incidence were statistically significant difference [(OR=2.22, 95%CI 1.25-3.93, P 0.05) vs. (OR= 2.14, 95%CI 0.75-6.12, P>0.05) vs. (OR=11.73, 95%CI 0.64-215.74, P>0.05) ]; 1h compared with 2 h patients with limbs, pain, hemorrhage rate had significant difference [(OR=0.09, 95%CI -0.13--0.05, P 0.05) vs. (OR=0.95, 95%CI 0.52-1.75, P>0.05) vs. (OR=0.96, 95%CI 0.54-1.73, P>0.05) ]. Conclusions 30 min decompression after TRI can reduce operative limb swelling and pain incidence rate. There is no obvious influence between puncture site bleeding and operative limb numbness. Key words: Radial artery; Coronary artery; Interventional therapy; Hemostasis; Compressing duration; TR Band