Toxoplasmosis represents the most frequent complication affecting the CNS of AIDS patients. In Europe and South America the prevalence of toxoplasmosis is higher than in the United States (50-75% to 15%), so the risk for the AIDS-associated toxoplasmosis is higher in this area, including Romania. Most of the AIDS patients have immunoglobulin G antibodies anti-Toxoplasma in their serum, like in the general population, so most of the cases represent a reactivation of a latent infection. We present a series of 5 cases with patients, aged between 19-29 years old, who developed cerebral toxoplasmosis. Three of the patients are multi-experienced, and for two patients the cerebral toxoplasmosis was the defining AIDS infection. Three patients had a CD4 count under 100 cells/cmm at the moment of their diagnosis, with low adherence for cART and for the prophylaxis with trimethoprim-sulfamethoxazole. All patients but one had detectable HIV viral load. Two of the patients are positive for B hepatitis, one of them also for hepatitis D. The clinical manifestations were persistent headache, confusion, lethargy, hemiparesis. All patients presented high levels for immunoglobulin G anti-Toxoplasma at the moment of the clinical manifestations, one patient presented immunoglobulin M anti-Toxoplasma. The MRI examinations revealed characteristic multiple lesions. The treatment was performed using trimethoprim-sulfamethoxazole for 6 weeks. The evolution of the patients under the treatment was favorable for all the patients, with the remission of the symptoms and without neurological complications; they received trimethoprim-sulfamethoxazole prophylaxis until their CD4 >200/cmm, for another three months Although difficult to diagnose, cerebral toxoplasmosis is treatable and curable, despite of all the associated AIDS pathology.