Solar power towers (SPTs) integrated with thermal energy storage are promising solutions for solar energy utilisation. Supercritical CO2 power cycles are acknowledged as an attractive option for dry-cooling SPT plants. However, abundant low-grade waste heat exists in the SCO2 gas cooler, which is directly dissipated to the ambient. In order to further improve the performance of SCO2-based SPT plants, organic Rankine cycle (ORC) systems can be introduced as a bottoming cycle subsystem. In this paper, an ORC subsystem is added to four different SCO2 cycle layouts, i.e., recuperated (RE), recompression (RC), intercooling (IC), and partial cooling (PC) cycles, to form combined cycle systems for SPT applications. A parametric study reveals that the thermal efficiency of the power block (i.e., the whole power cycle system), and the salt temperature difference across the receiver are the determining factors of the thermo-economic performance of SPT-SCO2-ORC plants. Design optimisation and annual performance evaluations are implemented using actual weather data in Delingha, China. Compared to the SPT plant with a standalone recuperated SCO2 cycle system, the annual electricity generation is increased by 19 % by integrating a bottoming ORC subsystem. The SPT-RC-ORC system produces the maximum electricity generation of 123 GW·h/year, while the SPT-RE-ORC system achieves the lowest levelised cost of electricity (LCOE) of 0.12 $/kW·h and the minimum payback time of 8.8 years. A wide range of solar irradiance conditions is further considered to generalise the performance evaluation of such combined cycle systems, with results showing that with the highest solar irradiance investigated (3700 sunshine hours, 1000 W/m2·h), the LCOE of the SPT-RE-ORC plant can be as low as 0.07 $/kW·h and the payback time is as short as 6 years. This study investigates optimal SCO2-ORC configurations for SPT applications based on annual performance evaluations, and presents preliminary assessments of the thermo-economic potential of ushc SPT-SCO2-ORC plants across a variety of solar resource conditions.