Abstract. The world of valorization of Cultural Heritage is even more focused on the virtual representation and reconstructions of digital 3D models of monuments and archaeological sites. In this scenario the quality and the performances offered by the virtual reality (VR) and augmented reality (AR) navigation take primary importance, improving the accessibility of cultural sites where the real access is not allowed for natural conditions or human possibilities. The creation of a virtual environment useful for these purposes requires a specific workflow to follow, combining different strategies in the fields of survey, 3D modelling and virtual navigation. In this work a specific case of study has been analyzed as a practical example, the church of ‘San Giorgio dei Genovesi’, settled in the Historic Centre of Palermo (Italy). The acquisition of geometric information has been obtained with the integration of Terrestrial Laser Scanner (TLS) technologies and the photogrammetric reconstruction from mini Unmanned Aerial Vehicle (UAV) equipment. The obtained point cloud has been georeferred considering a network of Ground Control Points (GCP) acquired by a Global Navigation Satellite System (GNSS) receiver. The final point cloud has been processed and properly simplified through 3D modelling procedures, to obtain a realistic and light 3D model reconstruction. The model has hence employed into a VR WEB navigation system and will be used for AR outdoor application in the future, allowing to obtain different solutions for empowering the accessibility of the cultural good. The strategy of 3D CH model reconstruction, followed in this work, could be considered a reference methodology for the development of VR gaming applications finalized to CH valorization and AR applications, applied to museums or touristic paths in historical centres.