The study of the shoreline erosion, accretion, and instability along the northwestern Mediterranean coast of Egypt between El-Dabaa – Ras El-Hekma was achieved using Digital Shoreline Analysis System (DSAS) software. The erosional/accretional changes were quantified via the End Point Rate (EPR) and Net Shoreline Movement (NSM) statistical parameters. To analyze and compute the magnitude of the shoreline displacement for the study area, three different intervals were adopted; these are long-term change (for one interval from 1990 to 2020), short-term changes (for three intervals: 1990–2000, 2000–2010, and 2010–2020), and seasonal change (for every 6 months from summer 2019 to winter 2020). Results revealed that the shoreline erosion was dominant over long-term change (1990–2020) showing an increase from −0.31 m/yr to −27.83 m/yr. The short-term shoreline analysis for the period from 1990 to 2020 with a 10-year time interval shows that the average rate changes during the first, second, and third intervals were −0.47 m/yr, −0.06 m/yr, and −1.12 m/yr; respectively. Finally, the average rate of shoreline change over the total period (1990–2020) was estimated at −0.55 m/yr. Accordingly, shoreline erosion is the dominant pattern in the study area. This erosion is mainly dependent on the major activities of unplanned coastal development. The main threats posed by the anthropogenic activities in the area are uncontrolled coastal urbanization, the lack of commitment to the setback regulations for building constructions, and the development of tourism resorts and recreational facilities which leads to habitat loss and the destruction of the natural protection system of the shore (dune).