Human actions are suspect to various compatibility phenomena. For example, responding is faster to the side where a stimulus appears than to the opposite side, referred to as stimulus–response (S–R) compatibility. This is even true, if the response is given to a different stimulus feature, while location itself is irrelevant (Simon compatibility). In addition, responses typically produce perceivable effects on the environment. If they do so in a predictable way, responses are faster if they produce a (e.g., spatially) compatible effect on the same side than on the other side. That it, a left response is produced faster if it results predictably in a left effect than in a right effect. This effect is called response-effect (R–E) compatibility. Finally, compatibility could also exist between stimuli and the effects, which is accordingly called stimulus-effect (S–E) compatibility. Such compatibility phenomena are also relevant for applied purposes, be it in laparoscopic surgery or aviation. The present study investigates Simon and R–E compatibility for touchless gesture interactions. In line with a recent study, no effect of R–E compatibility was observed, yet irrelevant stimulus location yielded a large Simon effect. Touchless gestures thus seem to behave differently with regard to compatibility phenomena than interactions via (other) tools such as levers.