The aim of the current research is to extrapolate the results of a cross-sectional study of patient and caregiver productivity loss in the first year after an acute coronary syndrome (ACS) or stroke conducted in seven European countries to 13 other European countries in which patient-level data collection was not feasible (Austria, Bulgaria, Croatia, Czech Republic, Denmark, Finland, Germany, Greece, Italy, Norway, Romania, Slovakia, Slovenia). The original study used a validated questionnaire to collect total time loss including patient initial hospitalisation and sick-leave, patient absenteeism after return to work, patient presenteeism and caregiver time. Patients included represented only those who could return to work, because of a specific interest in presenteeism. Mean total lost time from the original study was extrapolated and valued using national labor costs (€2017, updated to 2018). To ensure a conservative basis for extrapolation, we statistically identified and excluded extreme outliers from the original dataset (ACS N=8/196; Stroke N=5/198). The 13 countries were grouped according to their GDP and geography into Northern/Western and Southern/Eastern Europe. The original study estimated a mean (±SD) loss of 70.2±83.8 and 67.6±82.4 workdays for ACS and stroke patients respectively. After excluding extreme outliers, the annual time lost was 56.7±12.3 workdays per ACS patient/caregiver and 59.3±14.0 workdays per Stroke patient/caregiver. In Northern/Western Europe, this time loss resulted in mean (country range) indirect costs of €17,241 (€13,051-23,053) for ACS and €17,735 (€13,425-23,714) for Stroke. In Southern/Eastern Europe, estimated indirect costs amounted to €5,121 (€2,430-7,978) for ACS and €5,268 (€2,500-8,207) for Stroke. These estimates depend on countries’ healthcare/social welfare systems. Total productivity loss for a patient and caregiver in the first year after ACS/Stroke in Europe is substantial, amounting up to 60 workdays (25% of annual workdays). Further research in productivity loss and indirect costs should be conducted.