Air pollution poses a challenge to human life, meanwhile, air quality in human inhabitancy is usually given less attention. Therefore, the study aims at assessing air pollution at Takoradi Technical University (TTU-Akatakyi campus) and its environs. The assessment was done to determine the particulate matter in the study area using a Haz-dust Monitor-5000. Before data collection, the sampler was calibrated and set to start for 24 hours. Data recorded were analysed using Microsoft Office Excel. The results were compared to EPA-Ghana and WHO Guidelines Values. TTU Akatakyi Campus, Bokro Township, and Diamond Cement Factory recorded mean PM1 values of 3.10, 3.19, and 3.56 mg/m3, respectively. The highest PM2.5 mean value (3.57 mg/m3) was recorded at Diamond Cement Factory whereas the least PM2.5 (3.11mg/m3) was at TTU-Akatakyi Campus. The highest PM10 mean value (3.80 mg/m3) was recorded at Diamond Cement Factory while the least (3.12 mg/m3) was at TTU Akatakyi Campus. The highest recorded Total Suspended Particulate (TSP) mean value (3.62 mg/m3) was at Diamond Cement Factory while the least (3.11 mg/m3) was at TTU Akatakyi Campus. The recorded values were above EPA-Ghana and WHO guidelines, which implies that the air quality in the study area at the time of the study was harmful to human health.