The commissioning and quality assurance The Total Skin Electron Beam (TSEB) irradiation treatment is based on the AAPM's report 23, which describes the six-dual-field (Standford) technique, and the Hospital Israelita Albert Einstein (HIAE) follows this recommended guidance. The Dosimetric Materials Laboratory of the Instituto de Pesquisas Energéticas e Nucleares (IPEN-LMD) has tradition in research related to thermoluminescent materials and its clinical applications. Thus, aiming to apply the LiF:Mg,Ti, the most common TLD material, and CaSO4:Dy + Teflon produced at IPEN as easy-to-use alternatives to electron beams dosimetry and its parameters applied to TSEB, this paper reports a comparative study of the TL responses of both materials to dose evaluation in TSEB treatments. The TL response of both materials was evaluated in several TSEB parameter tests such as clinical field homogeneity, Monitor Units (MU) calculation, absorbed doses over the reference line and throughout the surface of the skin in a treatment simulation using AldersonRando anthropomorphic phantom. Results show that the field homogeneity measurements remained within ± 8% acceptance limit from AAPM Report 23, little to no energy dependency over the range of 4 o 9 MeV electron beams and, for clinical measurements and MU calculations, both TLDs present compatible results and can be used as alternative tools in TSEB dosimetry.