Total Response Research Articles

Effect of dietary supplementation of Spirulina platensis powder on performance, some serum biochemistry, digestive enzymes, microbial content, antioxidant parameters and immune responses of growing Japanese quail

This study was performed to examine the influences of Spirulina platensis powder (SPP) on growth performance, physiological status, blood biochemistry, and intestinal microbial population in quail. 240-10-days old Japanese quail chicks were distributed into five groups. Each group had four replicate pens with 12 birds each. The first group received a basal diet (control group). Groups from two to five received the basal diet with SPP at levels of 1.5, 3.0, 4.5, and 6.0% as dietary ingredients, respectively. Results clarified significantly higher live body weight and body weight gain (p < 0.001) with significant enhancements (p < 0.001) in feed conversion values for groups that received SPP levels, especially 4.5% compared with the control and other groups. Birds fed on a diet containing SPP had significantly higher amylase, trypsin and lipase levels (p < 0.001) than the control. Intestinal Lactobacillus sp. was significantly increased, and Escherichia coli and Salamonella populations were significantly decreased by dietary SPP levels (p < 0.001). Liver function, total lipid profile, antioxidant parameters and immune response were significantly affected by SPP levels compared with the control (p < 0.001). In conclusion, the inclusion of SPP until 4.5% in quail diets could improve the growth performance, intestinal microbial population and serum biochemical constituents of growing quail.

Spin mixing conductance and spin magnetoresistance of the iridate/manganite interface

We present results on experimental studies of spin current, measured under spin pumping at ferromag-netic resonance in wide frequency band 2-20 GHz for SrIrO3/La0.7Sr0.3MnO3 heterostructures fabricated by RF magnetron sputtering at high temperature. The epitaxial growth of the thin film in heterostructure by a cube-on-cube mechanism was confirmed by XRD and TEM analysis. Taking into account the con-tribution of anisotropic magnetoresistance the spin current was estimated as 1/3 of the total response. We show that both real and imaginary parts of spin mixing conductance are valuable for heterostructures with strong spin-orbit interaction in SrIrO3. Imaginary part of spin mixing conductance was estimated by means of shift of ferromagnetic resonance field of La0.7Sr0.3MnO3 layer in heterostructure. The spin mag-netoresistance was evaluated from angular dependencies of magnetoresistance measured in planar Hall configuration. In order to extract the influence of anisotropic magnetoresistance a La0.7Sr0.3MnO3 film was measured as well. The spin Hall angle for heterostructure was found higher than for interface Pt/ La0.7Sr0.3MnO3.

Effect of transcutaneous auricular vagus nerve stimulation on functional connectivity in the related brain regions of patients with depression based on the resting-state fMRI

To explore the brain effect mechanism and the correlation between brain functional imaging and cognitive function in treatment of depressive disorder (DD) with transcutaneous auricular vagus nerve stimulation (taVNS) based on the resting-state functional magenetic reasonance imaging (rs-fMRI). Thirty-two DD patients were included in a depression group and 32 subjects of healthy condition were enrolled in a normal group. In the depression group, the taVNS was applied to bilateral Xin (CO15) and Shen (CO10), at disperse-dense wave, 4 Hz/20 Hz in frequency and current intensity ≤20 mA depending on patient's tolerance, 30 min each time, twice daily. The duration of treatment consisted of 8 weeks. The patients of two groups were undertaken rs-fMRI scanning. The scores of Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) and Wisconsin card sorting test (WCST) were observed in the normal group at baseline and the depression group before and after treatment separately. The differential brain regions were observed before and after treatment in the two groups and the value of degree centrality (DC) of fMRI was obtained. Their correlation was analyzed in terms of HAMD, HAMA and WCST scores. The scores of HAMD and HAMA in the depression group were all higher than those in the normal group (P<0.05). After treatment, the scores of HAMD and HAMA were lower than those before treatment in the depression group; the scores of total responses, response errors and perseverative errors of WCST were all lower than those before treatment (P<0.05). The brain regions with significant differences included the left inferior temporal gyrus, the left cerebellar peduncles region 1, the left insula, the right putamen, the bilateral supplementary motor area and the right middle frontal gyrus. After treatment, the value of DC in left supplementary motor area was negatively correlated to HAMD and HAMA scores respectively (r=-0.324, P=0.012; r=-0.310, P=0.015); the value of DC in left cerebellar peduncles region 1 was negatively correlated to the total responses of WCST (r=-0.322, P=0.013), and the left insula was positively correlated to the total responses of WCST (r=0.271, P=0.036). The taVNS can modulate the intensity of the functional activities of some brain regions so as to relieve depressive symptoms and improve cognitive function.

Neutral Magic‐Angle Bilayer Graphene: Condon Instability and Chiral Resonances

The full optical response of twisted bilayer graphene at the neutrality point close to the magic angle within the continuum model (CM) is discussed. First, three different channels consistent with the underlying symmetry are identified, yielding the total, magnetic, and chiral response. Second, the full optical response in the immediate vicinity of the magic angle is numerically calculated, which provides a direct mapping of the CM onto an effective two‐band model. It is, further, shown that the ground state of the CM in the immediate vicinity of is unstable toward transverse current fluctuations, a so‐called Condon instability. Third, due to the large counterflow, the acoustic plasmonic excitations with typical wave numbers have larger energies than the optical ones and their energy density may be largely enhanced at certain frequencies which are denominated as chiral resonances. Finally, symmetry relations for the optical response and their consequences for the chiral response are discussed.

Awareness Level About Cervical Cancer, Human Papillomavirus (HPV) and Corresponding Vaccine Among Women Living in the Western Region of Saudi Arabia.

Background In this study, we aimed to evaluate the knowledge and awareness about cervical cancer, human papillomavirus (HPV) and its vaccine among women living in the western region of Saudi Arabia. Methodology Using a cross-sectional online survey, this study assesses the knowledge and awareness level of HPV and the risk factors of cervical cancer among women living in the western region of Saudi Arabia. The design of the questionnaire is based on several earlier studies in different populations. Results The total completed responses include a sample of 624 that was subjected to statistical analysis; the analysis showed that only 34.6% were aware of HPV. Participants who belonged to the 21-30 and 31-40-year-old groups had comparatively more awareness than other age groups (p<0.001). Most (83.8%) believed that it would cause cervical cancer. Less than half (45.8%) knew that there is a vaccine against HPV infection. When we assessed the willingness to receive the vaccine, it was found that 75.8% were willing to take it. Conclusions The study found that women in the western region of Saudi Arabia have limited knowledge of cervical cancer and HPV and its vaccine. There is a need to educate and promote awareness of HPV and its complications for women in the western region of Saudi Arabia.

Instrumental learning and behavioral persistence in children with attention-deficit/hyperactivity-disorder: does reinforcement frequency matter?

Prominent theoretical accounts of attention-deficit/hyperactivity-disorder (ADHD) hypothesize that reinforcement learning deficits underlie symptoms of ADHD. The Dynamic Developmental Theory and the Dopamine Transfer Deficit hypothesis assume impairments in both the acquisition and extinction of behavior, especially when learning occurs under partial (non-continuous) reinforcement, and subsequently the Partial Reinforcement Extinction Effect (PREE). Few studies have evaluated instrumental learning in ADHD and the results are inconsistent. The current study investigates instrumental learning under partial and continuous reinforcement schedules and subsequent behavioral persistence when reinforcement is withheld (extinction) in children with and without ADHD. Large well-defined samples of children with ADHD (n = 93) and typically developing (TD) children (n = 73) completed a simple instrumental learning task. The children completed acquisition under continuous (100%) or partial (20%) reinforcement, followed by a 4-min extinction phase. Two-way (diagnosis by condition) ANOVAs evaluated responses needed to reach the learning criterion during acquisition, and target and total responses during extinction. Children with ADHD required more trials to reach criterion compared to TD children under both continuous and partial reinforcement. After partial reinforcement, children with ADHD executed fewer target responses during extinction than TD children. Children with ADHD executed more responses than TD children during extinction, irrespective of learning condition. The findings demonstrate general difficulties in instrumental learning in ADHD, that is, slower learning irrespective of reinforcement schedule. They also show faster extinction following learning under partial reinforcement in those with ADHD, that is, a diminished PREE. Children with ADHD executed more responses during extinction. Results are theoretically important, with clinical implications for understanding and managing learning difficulties in those with ADHD, as they suggest poorer reinforcement learning and lower behavioral persistence.

Total neoadjuvant therapy in rectal cancer: a network meta-analysis of randomized trials.

To assess the efficacy of total neoadjuvant therapy (TNT) for rectal carcinoma in comparison with conventional chemoradiotherapy (CRT). A systematic review was performed according to the PRISMA guidelines. A Bayesian network meta-analysis was done using NetMetaXL and WinBUGS. This study was registered in PROSPERO on March 3, 2022 (No. CRD-42022307867). Outcomes of 2,719 patients from 10 randomized trials between 2010 and 2022 were selected. Of these 1,191 (44%) had conventional long-course CRT (50-54 Gy) and capecitabine, 506 (18%) had induction chemotherapy followed by CRT (50-54 Gy) and capecitabine (iTNT), 230 (9%) had long-course CRT (50-54 Gy) followed by consolidation chemotherapy (cTNT), and 792 (29%) undergone modified short-course radiotherapy (25 Gy) with subsequent chemotherapy (mTNT). Total pathologic complete response (pCR) was 20% in the iTNT group, 21% in the mTNT group, 22% in the cTNT group, and 12% in the CRT group. Statistically significant difference in pCR rates was detected when comparing iTNT with CRT (odds ratio [OR], 1.76; 95% credible interval [CrI], 1.06-2.8), mTNT with CRT (OR, 1.90; 95% CrI, 1.25-2.74), and cTNT with CRT groups (OR, 2.54; 95% CrI, 1.26-5.08). No differences were found in R0 resection rates. No significant difference was found in long-term outcomes. The early administration of systemic chemotherapy in the TNT regimen has improved short-term outcomes, though long-term results are underreported. Randomized trials with survival as the endpoint are necessary to evaluate the possible advantages of TNT modes.

Decoding algae under abnormal temperature variability with odorant as a responsive indicator

Harmful algal blooms impair the aesthetic quality and healthy performance of in-situ water. Worse yet, dramatic temperature variability arises additional difficulty in algal-induced risk assessment, which is so far poorly explored. Microcystis aeruginosa (FACHB 905), was selected to explore the odor-producing pattern (β-cyclocitral, the major odorant of the test alga) under several temperature-varying scenarios. Significant differences were observed in total β-cyclocitral yield between these scenarios, e.g., a rapid yield response as a result of acute temperature variation. Yield response was not only dependent on absolute temperature, but influenced by temperature variability stress. Acute increase (AI) or sequential increase (SI) in temperature caused extra production response, while the opposite was observed in groups with acute decrease (AD) and sequential decrease (SD) in temperature. Cell growth in AD group showed severe inhibition, with the specific growth rates fluctuating around half of that in 16-control. Whereas, SD could relieve such detrimental growth effects. Cell quota of β-cyclocitral yield was sensitive to temperature variation, with notable increase in AI and SI. Further, peaks in cell quota for SI group (79.3 %) were higher than for AI group (57.9 %). Cell quota variations in temperature-varying conditions contributed to the total yield response (R2 = 0.566–0.980) more than cell intensity variations (R2 = 0.0397–0.548). Further, it was also found that the internal mechanism by reactive oxygen species and pigments varied in various thermal scenarios. Overall, it was demonstrated that more than absolute value differences, temperature varying patterns across time influence algal behavior and related hazards, which should be noted in resource water quality management.

Тест пищевых установок (ЕАТ-26): оценка психометрических характеристик и факторной структуры на неклинической выборке 876 студенток

&lt;p style="text-align: justify;"&gt;The Eating Attitudes Test (EAT-26) is widely used all over the world, including Russia, for screening eating disorders, however, the psychometric characteristics and factorial structure of the questionnaire have not yet been studied on Russian non-clinical samples. This study involved 876 female students aged 17&amp;ndash;26 (M=20.11&amp;plusmn;1.79) from three cities (Moscow, Ryazan, and Arkhangelsk). All respondents were asked to fill out an adapted Russian version of EAT-26. To assess the retest reliability, 48 students from Ryazan filled out the questionnaire twice with an interval of one month. To assess construct validity, 293 female students from Ryazan filled out the Body Appreciation Scale (BAS) to assess a positive attitude towards the body, 281 students from Arkhangelsk filled out the Hospital Anxiety and Depression Scale (HADS). As a result, descriptive statistics of the total score and responses to individual items of EAT-26 were obtained. In accordance with the critical value of EAT-26 (&amp;ge;20), the risk group for eating disorders included 13.5% of the respondents. The high internal consistency (Cronbach's alpha &amp;mdash; 0.883) and retest reliability (r=0.865) of the EAT-26 total were shown. The confirmatory factor analyses failed to confirm the three-factor structure originally proposed by the authors of the questionnaire. Confirmatory factor analysis confirmed a five-factor model (&amp;chi;&lt;sup&gt;2&lt;/sup&gt;=226.584, df=81, p&amp;lt;10&lt;sup&gt;-6&lt;/sup&gt;, CFI=0.970, RMSEA=0.046, 90% CI [0.038; 0.052] with 15 items included (EAT-15), which has high rates of internal consistency and retest reliability (Cronbach's alpha &amp;mdash; 0.840; r=0.861). Psychometric characteristics and indicators of reliability and validity of EAT-26, EAT-15, and the five selected scales are given.&lt;/p&gt;

Contribution of sensory nerves to cutaneous reactive hyperaemia in non-Hispanic Black and White young adults.

What is the central question of this study? Does cutaneous sensory nerve-mediated vasodilatation differ between non-Hispanic Black and White young adults? What is the main finding and its importance? The magnitude of cutaneous reactive hyperaemia is lower in non-Hispanic Black relative to non-Hispanic White young adults, but the overall sensory nerve contribution is the same, suggesting that sensory nerve function is similar in both non-Hispanic Black and White young adults. The aim of this study was to assess cutaneous sensory nerve function, independent of nitric oxide, in non-Hispanic Black and White young adults. We tested the hypothesis that cutaneous reactive hyperaemia and sensory nerve-mediated vasodilatation would be lower in non-Hispanic Black young adults relative to non-Hispanic White young adults. Twenty-four participants who self-identified as non-Hispanic Black (n=12) or non-Hispanic White (n=12) were recruited. All participants underwent three bouts of reactive hyperaemia. An index of skin blood flow was measured continuously using laser-Doppler flowmetry at a control site and at a site treated with topical 4% lignocaine to inhibit sensory nerve function. Peak reactive hyperaemia was lower in non-Hispanic Black relative to non-Hispanic White participants (P<0.001). Total reactive hyperaemiawas lower in non-Hispanic Black [mean (SD); control, 4085(955)%CVCmax s; lignocaine, 2127 (639) percent maximal cutaneous vascular conductance * seconds, %CVCmax s] relative to non-Hispanic White [control: 6820 (1179)%CVCmax s; lignocaine, 3573 (712)%CVCmax s] participants (P<0.001 for both sites). There was no difference between groups for the calculated contribution of sensory nerves to either the peak [non-Hispanic Black, 25 (14)%; non-Hispanic White, 19 (13)%] or total reactive hyperaemic response [non-Hispanic Black, 48 (10)%; non-Hispanic White, 47 (10)%]. These data suggest that cutaneous reactive hyperaemia is lower in non-Hispanic Black young adults, but the sensory nerve contribution is similar in non-Hispanic Black and White young adults.

ABILITY, MOTIVATION, OPPORTUNITY-ENHANCING HRM PRACTICES AND CORPORATE ENVIRONMENTAL CITIZENSHIP: REVISITING THE MODERATING ROLE OF ORGANISATIONAL LEARNING CAPABILITY IN MALAYSIAN CONSTRUCTION COMPANIES

This study examines the connection between ability, motivation, opportunity-enhancing HRM practices and corporate environmental citizenship. Organisational learning capability is also introduced as a moderator between the connections of AMO-enhancing HRM practices and corporate environmental citizenship. Systematic sampling technique was utilized to determine the study sample with a total response of 150. The study found that ability and opportunity-enhancing HRM practices are related to corporate environmental citizenship except for motivation-enhancing HRM practices. Similarly, organisational learning capability has no moderating effect on such relationships. In addition to that, this study has provided a comprehensive understanding of corporate environmental citizenship in the construction industry in Malaysia. This substantially adds a new dimension to the literature.

The Drivers of Stress in Women Employees Caused by the Pandemic COVID-2019

The rationale of this article is to study and evaluate the stress faced by individuals, especially Indian working women within their families, during the outbreak of the COVID-19 pandemic. Through this study, the authors aim to highlight the impact of the pandemic on Indian women grappling with mental and emotional distress. For this study, primary research techniques have been used. A survey instrument was constructed and circulated among women working from home or employees of any firm. Based on the survey, focused group interviews were conducted with randomly selected females. The total responses for this study were 203. The study results were collated and a statistical analysis of multivariate regression was used to conclude the findings. From this study, three factors contributed to the overall stress levels faced by working women induced by the COVID-19 pandemic: depression, nervousness and anxiety. Many studies have examined healthcare workers and their stress levels during the global pandemic. However, there is little literature on Indian working women, especially those working in I.T. and manufacturing companies. This article aims to identify the factors that can lead to stress and burnout in Indian working women specifically during the COVID-19 pandemic.

State of research in adult Hospital Medicine: Updated results of a national survey and longitudinal analysis of national data.

We sought to understand the current state of research in adult Hospital Medicine by repeating a 2018 survey of leaders in Hospital Medicine with changes to improve the response rate of surveyed programs. We also analyzed the public sources of federal research funding and MEDLINE-indexed publications from 2010 through 2019 among members of the Society of Hospital Medicine (SHM). Of the 102 contacted leaders of Hospital Medicine groups across the country, 49 responded, for a total response rate of 48%. Among the 3397 faculty members represented in responding programs, 72 (2%) of faculty were identified as conducting research for more than 50% of their time. Respondents noted difficulties at every stage of the research development pipeline, from a lack of mentors to running a fellowship program to a lack of applicants seeking further research training. Improvements to our research training pipeline will be essential to the long-term improvement of our profession.

Abstract 1667: Elimusertib shows stronger antitumor activity than standard of care chemotherapy in pediatric solid tumor models

Abstract Elimusertib is a small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR) currently being tested in clinical trials. Despite the known anti-tumor activity in various cancer entities, its effect on many pediatric malignancies remains unknown. We assessed the preclinical activity of elimusertib in a cohort of over 40 cell lines and 30 patient-derived xenograft (PDX) models derived from pediatric solid tumors. Elimusertib reduced tumor growth in all PDX models, with 50% of them achieving stable disease, partial or total response, even in those derived from relapsed tumors. Moreover, elimusertib outperformed the effect of standard of care chemotherapy, particularly in alveolar rhabdomysarcoma. Molecular characterization of the models provide information on response biomarkers with diagnostic potential. In summary, elimusertib shows strong preclinical anti-tumor activity in pediatric solid tumor models, that may translate to clinically meaningful responses in patients. Citation Format: Fabian Fadi Pusch, Heathcliff Dorado García, Robin Xu, Dennis Guergen, Yi Bei, Lotte Brueckner, Claudia Roeefzaad, Jennifer von Stebut, Victor Bardinet, María del Rocío Chamorro Gonzalez, Angelika Eggert, Johannes H. Schulte, Patrick Hundsdoerfer, Georg Seifert, Kerstin Haase, Beat Schaefer, Marco Wachtel, Anja A. Kühl, Michael Ortiz, Antje M. Wengner, Monika Scheer, Anton G. Henssen. Elimusertib shows stronger antitumor activity than standard of care chemotherapy in pediatric solid tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1667.

To the question of the history of methods for teaching listening comprehension

The article presents the history of teaching methods for listening comprehension in Russian and foreign language teaching since the middle of the 20th century till the present day. In the framework of the Grammar- and Lexis-translation methods listening is not an obligatory part of foreign language learning and is considered as a supporting passive skill. In contrast, oral speech perception becomes of primary importance in the Audiolingual and Total physical response methods and Natural approach. For the first time, technology such as language labs and various audio materials comes into use. Next, the Strategy-based approach is designed for teaching listening. The Communicative approach and Content Based Instruction are characterised with balanced teaching of all skills. Thus, the article distinguishes the period when listening comprehension was not compulsory (till the middle of the 20th century); the period, when it played a key role in language teaching (60–70s) and the period when all skills are believed to be equally important (since 80s). A new milestone in listening research is 90s when new approaches for classification of listening skills, micro-skills and types are designed. At this time, a psycholinguistic side of speech perception becomes of interest. In the 21st century significance of teaching listening is reflected in Common European Framework of Reference (CEFR). The article shows a changing status of listening during the considered time period — from a supporting passive skill to a complex active skill involving a number of processes.

Lumateperone in Pooled Late-Phase Schizophrenia Trials: Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed

AbstractBackgroundLumateperone is an FDA-approved antipsychotic to treat schizophrenia and depressive episodes associated with bipolar I or bipolar II disorder as monotherapy and as adjunctive therapy with lithium or valproate. This post hoc analysis investigated the efficacy and tolerability of lumateperone in patients with schizophrenia via number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH).MethodsData were pooled from three late-phase 4–6 week placebo-controlled studies of lumateperone 42 mg/day in adults with schizophrenia and an acute exacerbation of psychosis (Study 005 [NCT01499563], Study 301 [NCT02282761], Study 302 [NCT02469155]). NNT and NNH were calculated vs placebo for several different Positive and Negative Syndrome Scale [PANSS] Total score response cutoffs (percent reduction from baseline) and for adverse events (AEs), respectively.ResultsIn the two informative studies (placebo, n=221; lumateperone, n=224), the NNT vs placebo for lumateperone was statistically significant for PANSS Total score reductions from baseline to 4 weeks/endpoint of ≥20% (NNT=9, 95% confidence interval [CI] 5–36) and ≥30% (NNT=8; 95%CI 5–21). In all studies pooled (placebo, n=412; lumateperone, n=406), study discontinuations due to AEs were uncommon and the NNH (389) was not statistically significant from placebo. The only AE with NNH vs placebo &lt;10 was somnolence/sedation (NNH=8; 95%CI 6–12). With lumateperone treatment, weight gain ≥7% from baseline was similar to placebo (NNH=112) and fewer patients experienced akathisia than placebo. Lumateperone LHH ratios were &gt;&gt;1 for all AEs (range 13.6–48.6) except somnolence/sedation (LHH~1).ConclusionLumateperone’s benefit-risk profile was favorable in late-phase schizophrenia trials.FundingIntra-Cellular Therapies, Inc.

Prevalence and risk factors of chronic respiratory symptoms in public and private school teachers in north-western Ethiopia: results from a multicentre cross-sectional study

ObjectiveThis study aimed to investigate the prevalence and risk factors of chronic respiratory symptoms among school teachers in Gondar city, north-western Ethiopia.DesignA school-based cross-sectional study was conducted from April to...

MP66-09 ASSESSING FINANCIAL LITERACY AND WELLBEING OF UROLOGY RESIDENTS

You have accessJournal of UrologyCME1 Apr 2023MP66-09 ASSESSING FINANCIAL LITERACY AND WELLBEING OF UROLOGY RESIDENTS Katherine Sinchek, Kyle Dymanus, Morgan Salkowski, Christopher Coogan, and Alexander Chow Katherine SinchekKatherine Sinchek More articles by this author , Kyle DymanusKyle Dymanus More articles by this author , Morgan SalkowskiMorgan Salkowski More articles by this author , Christopher CooganChristopher Coogan More articles by this author , and Alexander ChowAlexander Chow More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003329.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Physicians accrue significant debt throughout their medical education yet report less experience with and instruction in personal finance management than their age-matched peers. Our study aims to evaluate financial status, literacy, and attitudes in urology residents across the United States. METHODS: A web-based survey was sent to 146 ACGME-accredited urology residency programs in the United States. Respondents were asked to answer 50 questions covering personal debt, financial status, and willingness to participate in formal education on personal finance during residency. The survey included a validated questionnaire authored by the Financial Industry Regulatory Authority (FINRA) to provide objective data regarding financial literacy. RESULTS: 99 total responses were received from urology residents located in 23 states. Financial and debt status are reported in Table 1. 88 respondents answered the financial literacy portion of the survey, with an average correct score of 53% (+/-22.5%). Residents that reported their knowledge of personal finance and investing as high (7%) or above average (26%) were more likely to have higher scores than those reporting their knowledge as limited (38%) or having no knowledge (11%) (p=0.01). Lower debt level (<$100,000) was associated with a higher literacy score (p=0.01). Residents cited lack of time (75%), lack of resources (51%), and challenging subject matter (47%) as reasons for their limited financial knowledge. CONCLUSIONS: Responses indicate a high debt burden yet limited literacy in personal finance based on quantitative measures provided by the FINRA assessment. Although most residents reported confidence in ability to meet monthly costs of living, a survey of savings versus debt depicts residents in a precarious position. Formal education in personal finance was also assessed, highlighting a disparity in resident interest and what programs currently offer. While most residents reported having access to personal finance educational programming at their programs, almost all respondents indicated they did not feel it was adequate for their needs. These results suggest that the addition of a formal course on personal finances would be well-received and lead to improved financial wellbeing in this group. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e935 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Katherine Sinchek More articles by this author Kyle Dymanus More articles by this author Morgan Salkowski More articles by this author Christopher Coogan More articles by this author Alexander Chow More articles by this author Expand All Advertisement PDF downloadLoading ...

Postprandial Inflammatory and Metabolic Responses Induced by Authentic Mytilinis Cheese: A Preliminary, Crossover, Nutritional Intervention in Healthy Adults.

Several Mediterranean traditional cheeses may present a beneficial effect on postprandial metabolic and inflammatory modulation due to the presence of bioactive components. The objective of the present preliminary nutritional intervention was the investigation of the postprandial metabolic responses after the intake of traditional Authentic Mytilinis cheese in olive oil with herbs, compared to the corresponding responses after consumption of Italian Parmesan cheese, in healthy participants. A pilot crossover, randomized, single-blinded, intervention clinical trial was conducted in 10 healthy men and women subjects, aged 18-30 years, after random allocation into the control and the intervention groups. The participants received a high-fat carbohydrate meal containing either Authentic Mytilinis cheese (the authentic nonrefrigerated recipe) or Italian Parmesan PDO cheese. After a washout week, the participants consumed the same meals conversely. Differences in the postprandial responses of glucose, triglycerides, uric acid and serum total, HDL and LDL cholesterol levels, as well as of the plasma total antioxidant capacity according to the FRAP method, were determined between groups for fasting, 30 min, 1.5 h, and 3 h after meal intake. The results suggested that meals did not significantly affect postprandial metabolic and inflammatory responses. However, Authentic L Mytilinis cheese resulted in a lower increase of LDL cholesterol (p > 0.05) and induced a significant decrease of serum triglycerides (p < 0.05) in the last 1.5 h after a meal, compared to Italian Parmesan cheese. Further investigation with large prospective studies is necessary to validate the current findings.

Effects of motor imagery based brain-computer interface on upper limb function and attention in stroke patients with hemiplegia: a randomized controlled trial

BackgroundSeeking positive and comprehensive rehabilitation methods after stroke is an urgent problem to be solved, which is very important to improve the dysfunction of stroke. The aim of this study was to investigate the effects of motor imagery-based brain-computer interface training (MI-BCI) on upper limb function and attention in stroke patients with hemiplegia.MethodsSixty stroke patients with impairment of upper extremity function and decreased attention were randomly assigned to the control group (CR group) or the experimental group (BCI group) in a 1:1 ratio. Patients in the CR group received conventional rehabilitation. Patients in the BCI group received 20 min of MI-BCI training five times a week for 3 weeks (15 sessions) in addition to conventional rehabilitation. The primary outcome measures were the changes in Fugl-Meyer Motor Function Assessment of Upper Extremities (FMA-UE) and Attention Network Test (ANT) from baseline to 3 weeks.ResultsAbout 93% of the patients completed the allocated training. Compared with the CR group, among those in the BCI group, FMA-UE was increased by 8.0 points (95%CI, 5.0 to 10.0; P < 0.001). Alert network response time (32.4ms; 95%CI, 58.4 to 85.6; P < 0.001), orienting network response (5.6ms; 95%CI, 29.8 to 55.8; P = 0.010), and corrects number (8.0; 95%CI, 17.0 to 28.0; P < 0.001) also increased in the BCI group compared with the CR group. Additionally, the executive control network response time (− 105.9ms; 95%CI, − 68.3 to − 23.6; P = 0.002), the total average response time (− 244.8ms; 95%CI, − 155.8 to − 66.2; P = 0.002), and total time (− 122.0ms; 95%CI, − 80.0 to − 35.0; P = 0.001) were reduced in the BCI group compared with the CR group.ConclusionMI-BCI combined with conventional rehabilitation training could better enhance upper limb motor function and attention in stroke patients. This training method may be feasible and suitable for individuals with stroke.Trial registration: This study was registered in the Chinese Clinical Trial Registry with Portal Number ChiCTR2100050430(27/08/2021).