Total Score Of Quality Research Articles

Correlation between Quality of Work-Life and Job Burnout in Midwives.

Job burnout of healthcare professionals results in poor quality of care, making them leave the profession. A direct relationship between quality of work-life and job burnout is not clear among midwives. The aim of this study was to investigate the correlation between the quality of work-life and burnout in midwives. This correlational cross-sectional study was conducted by using census sampling and participation of 282 midwives working in all private and public hospitals with labor wards (n = 17) in Isfahan, Iran, in 2018. Quality of Work-life Questionnaire and Maslach Burnout Inventory were used. Partial correlation and regression analysis were used to analyze the data in SPSS.19 software. Regarding the three dimensions of job burnout, an average level of emotional exhaustion and personal accomplishment as well as a low level of depersonalization were observed in the participants. The total score of quality of work-life had a significant inverse correlation only with the dimension of emotional exhaustion (r = -0.43, p > 0.001). The dimensions of quality of work-life were predictive of 28% and 12% variance of job burnout in the dimensions of emotional exhaustion and personal accomplishment (R2 = 0.28 and R2 = 0.12, respectively). Job burnout is correlated to the quality of work life among midwives. To improve the quality of midwives' services and prevent their job burnout, especially emotional exhaustion, more attention should be paid to improving the quality of their work-life.

Validation of the Concise Assessment Scale for Children's Handwriting (BHK) in an Italian Population.

Handwriting difficulties represent a common complaint among children and may cause a significant delay in motor skills achievement. The Concise Assessment Scale for Children's Handwriting (BHK) assesses handwriting skill in clinical and experimental settings, providing a quick evaluation of handwriting quality and speed through a copying text. The aim of the present study was to validate the Italian adaptation of the BHK in a representative primary school population. Overall, 562 children aged 7-11 from 16 public primary schools of Rome were included and asked to copy a text in 5 min using cursive handwriting. Handwriting quality and copying speed were measured. The included population followed a normal distribution for the BHK quality scores. Sex influenced the total quality scores, whereas school level influenced the copying speed. The BHK quality score was higher in girls (p < 0.05) and resulted as a stable parameter along the school years, without significant variations with regard to the years spent in handwriting exercise (p = 0.76). The handwriting speed was influenced by school level, and significant differences were found for each of the grades from the second to the fifth (p < 0.05), but not for gender (p = 0.47). Both BHK measures represent a helpful tool for the characterization and assessment of children with handwriting difficulties. The present study confirms that sex influences total BHK quality score, while school level influences handwriting speed.

Assessing the Quality of Educational Services from the Viewpoint of Clinical Teachers and Medical Students Using SERVQUAL Model

Background: One of the basic steps in improving the quality of health programs is to evaluate it from the viewpoint of beneficiaries. SERVQUAL is a model that is very effective in evaluating the quality of services. Objectives: The aim of this study was to assess viewpoint of clinical teachers and medical students about the quality of educational services provided based on the SERVQUAL model in 2018. Methods: This research was descriptive-analytical and 80 medical students and clinical teachers of Shahid Beheshti Teaching Hospital in Kashan participated in it. Data collection tool was SERVQUAL standard questionnaire including 22 items and a 7-point Likert scale. Data were analyzed using SPSS 16 software and descriptive and inferential statistics (t-test) (P ≤ 0.05). Results: The expectations (optimal status) of the participants in the total score of service quality and all its dimensions were significantly higher than their perceptions (current status) (P &lt; 0.001). In other words, from the viewpoint of individuals in all dimensions of quality and their total score, there is a gap that the most significant quality gap in the guarantee dimension (-2.91 ± 1.34), and the lowest in the empathy dimension (-1.54 ± 2.02). The mean gap between the total expectations and perceptions score and its dimensions from the viewpoint of women was higher than men but was not statistically significant (P &gt; 0.05). There was also a significant relationship between the service quality gap and individuals' educational levels (P &lt; 0.05). Conclusions: In all aspects of the quality of educational services, there was a negative gap (failure to meet expectations) between expectations and their perception, and this gap was greater in dimension of confidence. The observed differences between the five dimensions of quality should be used as a guide for planning and resource allocation.

Food Security is Associated with Higher Diet Quality Among Children of the US–Affiliated Pacific Region

BackgroundThe prevalence of food insecurity and its relationship to diet quality are factors impacting the health of persons living across the United States–affiliated Pacific region (USAP). ObjectivesThe aim of this study was to describe characterize the relationship between household food security status and diet quality of 2- to 8-y-old children across jurisdictions in the USAP. MethodsBaseline data from 2- to 8-y-olds (n = 3099) enrolled in the Children’s Healthy Living Program for Remote Underserved Minority Populations in the Pacific region, an obesity prevention study conducted in communities across Alaska, American Samoa, Commonwealth of the Northern Mariana Islands (CNMI), Guam, and Hawaii, and a concomitant prevalence study in communities across the Freely Associated States (FAS) (the Federated States of Micronesia: Kosrae, Pohnpei, Chuuk, Yap; Republic of Marshall Islands; Republic of Palau) were collected in 2012. Caregivers self-reported sociodemographic data and food insecurity. Assisted by their caregiver, children completed two dietary records on nonconsecutive, randomly assigned days. The Healthy Eating Index 2005 (HEI-2005) was used to assess the diet quality. Data were summarized overall and by jurisdiction. Differences in HEI-2005 and HEI component scores among jurisdictions and by household food security status were tested using 1-factor ANOVA. ResultsHalf or more of participants from American Samoa, Guam, CNMI, and FAS reported household food insecurity (n = 295, 59.7%; n = 292, 49.9%; n = 267, 54.6%; n = 572, 69.0%, respectively). HEI-2005 scores varied by jurisdiction (P < 0.001) and were significantly lower among FAS participants (54.7 ± 1.2) than among all other jurisdictions (P < 0.05). Total diet quality scores did not differ by food security status (59.9 ± 0.8 food secure compared with 58.3 ± 1.1 food insecure, P = 0.07); however, most diet quality adequacy component scores were significantly higher and moderation component scores significantly lower among participants in food secure households than those in food insecure households. ConclusionsSignificant differences in children’s diet quality and household food security existed across USAP jurisdictions.

Relationship Between Perceived Stress and Quality of Life of Nurses Working in COVID-19 Wards

Background: Stressors during the COVID-19 pandemic, led to lack of concentration and lack of energy to achieve career goals, fatigue, poor performance, burnout and reduced quality of life of people, especially nurses. Methods: This descriptive-analytical study was done with the aim of determining the relationship between perceived stress and quality of life of nurses working in the care wards of patients with COVID-19 in hospitals affiliated to Mazandaran University of Medical Sciences (Mazandaran, Iran) during 2020-2021. Inclusion criteria included willingness to participate in the study, having at least a bachelor's degree in nursing and working in the care wards of patients COVID-19. Data collection tools included demographic information questionnaire, Cohen Perceived Stress Questionnaire and WHO Quality of Life Questionnaire. Frequency, percentage, Mean and standard deviation indices were used to describe the variables. Also, Mann-Whitney, Kruskal-Wallis and Spearman correlation coefficients were used to ass the relationship between variables. Results: The Mean (SD) age of participants was 33.48 (6.64) years. Most were female (%73.3). The total scores of quality of life and perceived stress variables of nurses were 47.63±24.31 and 27.62±4.61, respectively. Nurses' scores of quality of life domains included Physical Health, Psychological, Social Relationships and environmental domain were 46.52±12.69, 46.57±12.70, 46.39±19.45 and 50.52±10.52, respectively. Nurses' quality of life had a direct significant relationship with the variables of sleep quality and job satisfaction (P&lt;0.001). Perceived stress score also had a significant inverse relationship with physical and social dimensions and total quality of life score (P&lt;0.001). Conclusions: Based on the results of this study and the negative effects of nurses' perceived stress on their quality of life, it is necessary to pay serious attention to nurses' concerns. It is recommended to Be considered appropriate interventions to reduce perceived stress and improve the quality of life in nurses who care for patients with Covid-19.

Enhancing Workforce Capacity to Improve Immunization Data Quality using Low Dose High-Frequency Intervention Approach in Ebonyi State, Nigeria: A Randomized Controlled Study

ABSTRACT Background: Immunization data quality is poor, particularly in developing countries. This study evaluated the effect of a low-dose high-frequency (LDHF) capacity-building training approach in improving immunization data quality in Ebonyi State, Nigeria. Methods: A randomized controlled study was conducted in 145 health facilities selected through cluster sampling in Ebonyi State. The intervention comprised low but frequent training doses, supportive supervision, and peer mentoring delivered onsite by immunization officers to facility health workers. Immunization data quality was compared before and 6 months after the intervention using an interviewer-administered validated data quality self-assessment questionnaire. A percentage score ≥ 80% was classified as good quality. Variables were compared with the Student’s t and Chi-square significant tests. Findings: The total mean score of immunization data quality was higher in the intervention group, 66.8 ± 11.0, than in the control group, 55.5 ± 16.6 (P = 0.001). A higher proportion of facilities in the intervention (54.2%) than the control group (24.7%) had overall good quality data (P = 0.001). Similarly, a higher proportion of the intervention than the control group had good quality in the immunization monitoring system elements—recording, reporting, archiving, demographic information, core output, and use of evidence for action (P &lt; 0.05). Health facilities with accurate data were higher in the intervention group, 95.8%, than in the control group, 71.1% (P = 0.001). A higher proportion in the intervention (93.7%) compared to the control group (68.0%) had complete data (P = 0.001). Conclusion: The study found low-quality immunization data, which improved more in the intervention group compared to the control group. This intervention approach should be adopted and scaled up.

A narrative medicine‐based training program increases the humanistic care quality of new nurses in cancer hospital

AbstractWith the change of medical model, the cancer nurses should not only pay attention to patients' physical pain, but also patients' psychological distress, which requires cancer nurses to have a high quality of humanistic care. This study aims to explore the humanistic care quality of new nurses in cancer hospital and effects of the narrative medicine‐based training program on the new nurses of cancer hospital. A total of 101 new nurses in a cancer hospital received the narrative medicine‐based training in 2020. Before and after the training, they were investigated with humanistic care quality questionnaire and empathy ability questionnaire. The course included narrative therapy overview, narrative medicine overview, narrative nursing, psychological nursing cases of cancer patients, and so on. After training, the total score of the humanistic care and quality empathy ability increased significantly, and the comparison was statistically significant. The total score of empathy after the training (98.44 ± 2.23) was higher than the score before the training (86.35 ± 7.53) (p &lt; .05). The total score of humanistic care quality after the training (184.45 ± 14.34) was higher than the score before the training (161.45 ± 15.45) (p &lt; .01). The scores of all dimensions were statistically significant. The narrative medicine‐based training program could increase the empathy ability of the new cancer nurses and improve the humanistic care quality. This program is suitable for clinical promotion and application. The study findings could have implications for medical institute to increase the humanistic care quality of new nurses.

Effect of Teach-back and Douyin platform short video health education in women receiving infertility treatment.

To evaluate the effect of intervention by Teach-back and Douyin platform short video health education on stigma, reproductive quality of life, family intimacy and family adaptability in women receiving infertility treatment. This study is a quasi-experimental study. The intervention period is 6 weeks, and the study was implemented between January 2022 and August 2022. A total of 80 women (40 in the control group and 40 in the observation group) receiving infertility treatment were included in the study. The control group was given routine health education intervention, and the observation group was given Teach-back and Douyin platform short video health education on the basis of routine health education. The Chinese version of the Infertility Stigma Scale, the Infertility Quality of Life Questionnaire and the Family Intimacy and Adaptability Scale were used to evaluate the effects before and after the intervention. After the intervention, the total score of stigma in the observation group was significantly lower and lower than that of the control group (P < 0.05) and the total score of reproductive quality of life in the observation group was significantly higher than that of the control group (P < 0.05). The dissatisfaction score of family intimacy in the observation group was significantly lower than that of the control group (P < 0.05), and the dissatisfaction score of family adaptability in the observation group was significantly lower than that of the control group (P < 0.05). Teach-back and Douyin platform short video health education can reduce the stigma in women receiving infertility treatment and improve their reproductive quality of life, family intimacy and family adaptability.

An exploration of safety and feasibility of transoral vestibular endoscopy in the treatment of thyroid malignant tumors

Objective:To investigate the safety and feasibility of transoral vestibular endoscopy in the treatment of patients with thyroid malignant tumors. Methods:120 patients with thyroid cancer admitted to Xi 'an Central Hospital from January 2019 to December 2021 were selected and randomly divided into endoscopic surgery group（60 cases） and traditional open surgery group（60 cases）. The general operation conditions, postoperative complications and postoperative quality of life were compared between the two groups. Results:The intraoperative blood loss, indwelling drainage tube time and average length of hospital stay in the endoscopic surgery group were significantly lower than those in the traditional open surgery group （P<0.05）, while the operation time and number of lymph nodes dissected were significantly higher than those in the traditional open surgery group （P<0.05）. There was no significant differences in VAS score at 24h after surgery, white blood cell count, TgAb （+） and temporary hypothyroidism between the two groups at 24 h after operation （P >0.05）. The CRP, total drainage volume, TgAb and serum calcium in the endoscopic surgery group were higher than those in the traditional open surgery group, and the PTH and Tg were lower than those in the traditional open surgery group （P<0.05）.One case of hoarseness,2 cases of extremities numbness, 1 case of subcutaneous effusion and 2 cases of chin nerve injury occurred in the endoscopic surgery group, the total incidence of postoperative complications was 10.00%. Five cases of hoarseness, 11 cases of choking cough limbs numbness, 1 case of drinking water, 1 case of postoperative bleeding and 4 cases of subcutaneous effusion occurred in the traditional open surgery group, the total postoperative incidence of complications was 36.67%, the total incidence of complications in endoscopic surgery group was lower than that in traditional open surgery group （P<0.05）. The total scores of physiological status, social/family status, emotional status, functional status and quality of life in endoscopic surgery group were significantly lower than those in traditional open surgery group （P<0.05）. Conclusion:The application of oral vestibular endoscopy in the treatment of thyroid malignant tumors has the advantages of good surgical status and postoperative recovery, fewer postoperative complications.The patient was well tolerated,with positive safety，this technique has high clinical application value.

Investigating different dimensions of infertile women’s quality of life: a descriptive cross-sectional study

BackgroundInfertility is a major challenge in the life of women which affects their quality of life. Infertile women's quality of life is a relatively new field of research that has recently been considered by health researchers. However, there has been no standard tool for measuring different aspects of infertile women's quality of life with female factors, and general and specific tools of infertile couples have been used to assess their quality of life. This study, thus, aimed to analyze different aspects of the quality of life of infertile women.MethodsThis descriptive cross-sectional study was conducted on 320 infertile women referred to a teaching hospital affiliated with Mazandaran University of Medical Sciences and private infertility treatment centers in Sari, Iran. Demographic and fertility characteristics and the quality of life questionnaire for infertile women questionnaire (a 25-item tool was designed which measured 7 factors of psychological effects, sexual life with infertility family and social effects, infertility-related concerns, physical effects, adaptive approaches and factors preventing infertility adaptation), were recruited for data gathering. Data were analyzed using SPSS version 22. Descriptive statistics (percentage, mean, standard deviation), correlation coefficient, independent sample t-test, and multiple linear regression were used. P-values less than 0.05 were considered statistically significant.ResultsThe total mean score of infertile women's quality of life was 65.68 ± 8.91%. Findings were indicative of infertile women's quality of life in the dimensions of adaptive approach (70.48 ± 15.02%), psychological (67.88 ± 12.06%), family and social (64.63 ± 10.76%), physical, 63.42 ± 11.36%), inhibitory factors/ factors preventing adaptation (60.98 ± 8.24%), related concerns (51.52 ± 10.21%) and sexual life (40.12 ± 14.28%). According to the final multiple linear regression model, women's education (B = 2.57, p < 0.001), spouse's education (B = 1.56, p = 0.046), economic status (B = 1.64, p < 0.001), age of women (B = -0.62, p < 0.001), age of spouse (B = -0.65, p < 0.001), duration of infertility (B = -0.36, p = 0.024) and duration of marriage (B = -0.39, p = 0.022) were the final predictors of the quality of life score in infertile women of the study.ConclusionGiven that infertility causes extensive changes in individuals, families, and social dimensions of infertile women, it can affect their quality of life. We can take steps to improve the health of infertile women by promoting various dimensions of their quality of life.

Female Genital Mutilation, Sexual Quality of Life and Marital Relationship: A Case-Control Study From Iran.

Studies on the sexual consequences of female genital mutilation is mostly related to sexual function, while sexual quality of life is a more objective criterion for studying the effects of genital mutilation on the women's sexual life. The purpose of this study was to compare the sexual quality of life and marital relationship in the mutilated women with other women living in the Kurd region of Mahabad (Iran). In a case-control study, 600 married women (300 mutilated and 300 non-mutilated women) who referred to the health centers completed the sexual quality of life questionnaire (SQOL-F) as well as demographic questionnaires. Data analyzed using chi-square, independent t-test, and linear regression model with stepwise method at 95% confidence level. The mean total score of sexual quality of life in the mutilated group (40.28±16.76) was significantly lower than the control group (45.29±19.16). The chance of having a higher score of sexual quality of life in the mutilated group was 0.13 times lower than the control group. This value was 0.16 times for self-worthlessness area, 0.10 for sexual repression, 0.12 for psycho-sexual feeling, and 0.32 for sexual and marital satisfaction areas (p <0.05). In the mutilated group, the total score of sexual quality of life was significantly correlated with age, income, spouse's violence, spouse's infidelity, intercourse frequency, and residence status (P <0.05). Female genital mutilation can decrease the sexual quality of life and increase the chance of negative consequences such as spouse violence, infidelity, and intercourse reduction.

Effect of Islamic Dhikr on Pain Severity and Quality During Dressing Change in Patients with Burns

Background: Pain is a process of daily burn dressing changes. Evidence shows the effect of God’s name on reducing pain. Objectives: This study aimed to evaluate the effect of Islamic dhikr on pain severity and quality of burn dressing change. Methods: This clinical trial was performed on 71 patients with burns in 2017. Patients were selected by convenience sampling and randomly assigned to intervention and control groups. Then, 10 minutes before the start of the dressing change, the participants were asked to repeat the praises of Hazrat Fatima (PBUH). Patients in the control group received routine care. Pain severity was measured in patients before and 15, 30, 45, and 60 minutes after the dressing change with the Visual Analog Scale (VAS). The pain quality of patients was measured 15 minutes after the dressing change with the modified McGill Pain Questionnaire (MPQ). Data were analyzed using SPSS version 22 software with descriptive and analytical statistics. Results: The independent t-test showed a statistically significant difference between the experimental and control groups in terms of mean pain severity 15, 30, and 45 minutes after the dressing change (P = 0.001, P = 0.04, and 0.007, respectively). Also, the repeated-measures analysis showed that the variation of the mean pain severity scores was statistically significant across all phases of the study (F = 30.42, P &lt; 0.001). The results showed a statistically significant difference in the mean scores of sensory and emotional dimensions and the total score of pain quality between the two groups (P = 0.003, P = 0.07, and P = 0.047, respectively). Conclusions: Islamic dhikr can reduce pain during burn dressing changes.

Research Note: Responses of broiler chickens to in ovo feeding with clove and cinnamon extract under hot-humid environments

An experiment was carried out to evaluate the responses of broiler chickens to in ovo injection of aqueous extracts of clove and cinnamon under a hot-humid environment. The study involved the use of seven hundred hatching eggs from broilers (Ross 308) which were incubated with the use of standard protocol (37.8°C). The incubating eggs (100 each) were randomly selected and assigned to 7 treatments on day 17.5 of incubation, viz.: un-injected eggs (UE), eggs injected with 0.5 mL distilled water (DW), 2 mg clove (CL2), 4 mg clove (CL4), 2 mg cinnamon (CN2), 4 mg cinnamon (CN4), and 3 mg ascorbic acid (AA).Data on physiological parameters, hatchability, chick quality, and anatomical characteristics of the chicks were collected and analyzed using one-way analysis of variance. The results obtained revealed that the hatchability of eggs of AA and CN2 was higher compared to DW and UE. However, the hatchability of DW and UE was higher than those of CN4. The total chick quality scores of the control were similar to the other groups. Chick weights at hatch were similar in CL2, CN2, and AA but heavier than CN4, CL4, UE, and DW. The chick-to-egg ratio in AA was comparable to CL2 and CN2 but higher than UE, DW, CN4, and CL4. Total scores for chick quality of AA birds were similar to those of UE, CL2, and CL4 birds but higher than DW, CN2, and CN4 birds.

Respiratory and Sound Pressures, Maximum Phonation Time, Cervical Disability and Voice-Related Quality of Life of Teachers

IntroductionMany teachers report discomfort and a decrease in the quality of aerodynamic, respiratory, and cervical vocal aspects as well as of vocal self-assessment. ObjectiveCharacterize and correlate measurements of Sound Pressure Levels, Maximum Phonation Time of /a/, Maximum Respiratory Pressures, Voice-Related Quality of Life and cervical pain in teachers with vocal and musculoskeletal complaints and no organic vocal fold lesions, and compare with normative values. MethodsRetrospective study with 56 teachers. Anamnesis, video laryngoscopy, hearing screening, measurements of sound pressure and maximum phonation time, and manovacuometry were performed. Self-assessment protocols for Voice-Related Quality of Life and Neck Disability Index were completed. Resultsthere was significant higher Sound Pressure Levels; significant lower Maximum Phonation Time of /a/, Maximum Expiratory Pressure, and total and physical scores of Voice-Related Quality of Life; most participants had mild cervical disability; there was a negative correlation between Maximum Expiratory Pressure and Neck Disability Index, between Maximum Inspiratory Pressure and Maximum Sound Pressure Level, and between Neck Disability Index and Voice-Related Quality of Life. ConclusionThe results showed that there are damages and inadequacies in teachers’ vocal production which affect their quality of life. Therefore, it is necessary to pay attention to the conditions of use of the voice by professionals, and to their health education.

IMPACT OF SLEEP QUALITY ON QUALITY OF LIFE IN PATIENTS WITH ANXIETY DISORDERS

Modern scientific sources point out a close connection between depression, anxiety, psychological distress and low quality of life. The purpose of this study is to assess the impact of sleep quality on the quality of life in patients with anxiety disorders of neurotic origin. Examination of 81 patients with anxiety disorders of neurotic origin and dyssomnic disorders was carried out using clinical-psychopathological, psychodiagnostic and statistical research methods. The psychodiagnostic method included determining the level of stress load according to the PSM-25 questionnaire, the level of anxiety and depression by the HADS scale, the severity of the mental and somatic component of anxiety according to the HAM-A scale, assessing the quality of life according to the "SF-36" scale, studying sleep quality disorders according to the PSQI questionnaire.&#x0D; Depending on the level of psychological stress based on the PSM-25 scale, 3 groups were formed: group 1 included 25 (30.7%) people with a low level of stress, group 2 included 29 (35.8%) individuals with an average stress level, and group 3 included 27 people (37.4%) with a high stress level. Analysis according to the HADS scale has shown that anxiety symptoms prevail over depressive symptoms in all examined subjects. According to the HAM-A scale, the average score of the somatic and mental components in the group 1 is significantly lower compared to the group 2 (p&lt;0.001) and the group 3 (p&lt;0.001).&#x0D; This study has demonstrated that as the level of stress increases, there is a tendency for quality of life indicators to decrease in all spheres of functioning. Significantly worse sleep quality scores were found in patients with anxiety disorder and high mental stress level compared to those with moderate or low levels. There is a strong negative correlation between indicators by the "vital activity" scale and such components of sleep quality as "daytime dysfunction", "sleep latency" and the total score of sleep quality, between indicators by the scales "role functioning due to physical condition" and "daytime dysfunction". It has been found out that with increasing pain intensity, all indicators of sleep quality decline. The data obtained should be taken into account in developing patient-centred treatment plan for this group of patients.

The health-related quality of life of lung cancer patients with EGFR-TKI-related skin adverse drug reactions and its relationship with coping style and self-management.

The status and associated factors of the health-related quality of life of non-small-cell lung cancer (NSCLC) patients under targeted anti-cancer therapy have not been investigated. Self-management and coping style have been proven to be closely related to patients' health-related quality of life. Based on these observations, this study was designed to firstly assess the status of health-related quality of life, and then explore the relationships among coping styles, self-management, and health-related quality of life of NSCLC patients with skin adverse drug reactions under targeted therapy. We performed a cross-sectional study including 536 NSCLC patients with skin adverse drug reactions under targeted therapy in cancer clinics of three hospitals in China between May 2020 and May 2021. Structured questionnaires, including the Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitor 18, Cancer Patient Self-management Evaluation Scale, and Medical Coping Modes Questionnaire, were used to collect data. Relationships among coping style, self-management, and health-related quality of life were identified by Pearson correlation analysis and a multiple linear regression algorithm. The total score of health-related quality of life was 46 ± 12.84 in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy. Health-related quality of life was positively correlated with self-management (r = 0.785, P < 0.01) and facing (r = 0.807, P < 0.01) and negatively correlated with yield (r = - 0.718, P < 0.01), avoidance (r = - 0.711, P < 0.01), and the severity of skin adverse reactions (r = - 0.722, P = 0.000). Via multiple linear regression analysis, we identified some significant factors associated with health-related quality of life, including age, education level, combination of medicine, Charlson Comorbidity Index, stages of disease, facing, yield, symptom management, daily activity management, psychological and emotional management, self-efficacy, and self-management (P < 0.05). NSCLC patients with skin adverse drug reactions undergoing targeted therapy generally had a compromised health-related quality of life. The critical factors that were associated with the status of health-related quality of life were age, education level, comorbidity, the combinatorial application of drugs, stage of disease, self-management, and coping styles.

A preliminary study of comprehensive behavioral intervention for tics in Chinese children with chronic tic disorder or Tourette syndrome.

To investigate the adaptability of Comprehensive Behavioral Intervention for Tics (CBIT) for a Chinese population, and evaluate the efficacy of combined CBIT and pharmacotherapy (CBIT + PT) compared to CBIT or pharmacotherapy (PT) alone for reducing tics and for improving the quality of life (QoL) in a sample of Chinese children with chronic tic disorders (CTD) and Tourette syndrome (TS). In this 10-week randomized controlled pilot trial, 37 outpatients aged between 6 and 16 years affected by TS and CTD were randomly assigned to receive CBIT (n = 22) or PT alone (n = 15). Considering the feasibility, the patients allocated to the CBIT treatment group could further choose whether to simultaneously take medicine voluntarily, resulting in a CBIT alone group (n = 12) and a CBIT + PT group (n = 10). At baseline, no significant difference was found between the three groups in the demographic and clinical characteristics (p > 0.05). All three groups showed a significant reduction in tic severity after treatment assessed by the Yale Global Tic Severity Scale (YGTSS) severity score [F (2,33) = 35.05, p < 0.001, η p 2 = 0.51], the score of the Clinical Global Impression scale for Improvement (CGI-I) [F (1,34) = 13.87, p = 0.001, η p 2 = 0.29], and YGTSS impairment score [F (2,33) = 31.71, p < 0.001, η p 2 = 0.48]. Significant interactions were found between the time-point and group in emotional functioning [F (2,29) = 4.39, p = 0.02, η p 2 = 0.23], psychosocial functioning [F (2,29) = 5.93, p = 0.007, η p 2 = 0.29], and total QoL score [F (1,34) = 3.72, p = 0.04, η p 2 = 0.20] of Pediatric Quality of Life Inventory (PedsQL 4.0) for children suggesting a significantly larger improvement in emotional functioning, psychosocial functioning, and total QoL score of the life quality in the CBIT group for children self-report. PedsQL for proxy report only showed a significant main effect of time-point in physical functioning [F (1,33) = 8.35, p = 0.01, η p 2 = 0.2], emotional functioning [F (1,33) = 10.75, p = 0.002, η p 2 = 0.25], psychosocial functioning [F (1,34) = 11.38, p = 0.002, η p 2 = 0.26], and total Qol score [F (1,34) = 13.21, p = 0.001, η p 2 = 0.29]. CBIT is probably effective in reducing tic severity in Chinese children with tic disorders. CBIT + PT may not be superior to CBIT alone in reducing tic severity and improving quality of life. CBIT alone showed advantages in improving quality of life over CBIT + PT and PT alone. CBIT might be an appropriate treatment option for patients with tic disorder in Chinese mainland.

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults.

Sleep abnormalities are prevalent in Alzheimer's disease, with sleep quality already impaired at its preclinical stage. Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer's disease. However, previous studies are limited by either a lack of Alzheimer's disease biomarkers, reduced sample size or cross-sectional design. Understanding if, when, and how poor sleep contributes to Alzheimer's disease progression is important so that therapies can be targeted to the right phase of the disease. Using the largest cohort to date, the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study, we test the hypotheses that poor sleep is associated with core Alzheimer's disease CSF biomarkers cross-sectionally and predicts future increments of Alzheimer's disease pathology in people without identifiable symptoms of Alzheimer's disease at baseline. This study included 1168 adults aged over 50 years with CSF core Alzheimer's disease biomarkers (total tau, phosphorylated tau and amyloid-beta), cognitive performance, and sleep quality (Pittsburgh sleep quality index questionnaire) data. We used multivariate linear regressions to analyse associations between core Alzheimer's disease biomarkers and the following Pittsburgh sleep quality index measures: total score of sleep quality, binarized score (poor sleep categorized as Pittsburgh sleep quality index > 5), sleep latency, duration, efficiency and disturbance. On a subsample of 332 participants with CSF taken at baseline and after an average period of 1.5 years, we assessed the effect of baseline sleep quality on change in Alzheimer's disease biomarkers over time. Cross-sectional analyses revealed that poor sleep quality (Pittsburgh sleep quality index total > 5) was significantly associated with higher CSF t-tau; shorter sleep duration (<7 h) was associated with higher CSF p-tau and t-tau; and a higher degree of sleep disturbance (1-9 versus 0 and >9 versus 0) was associated with lower CSF amyloid-beta. Longitudinal analyses showed that greater sleep disturbances (1-9 versus 0 and >9 versus 0) were associated with a decrease in CSF Aβ42 over time. This study demonstrates that self-reported poor sleep quality is associated with greater Alzheimer's disease-related pathology in cognitively unimpaired individuals, with longitudinal results further strengthening the hypothesis that disrupted sleep may represent a risk factor for Alzheimer's disease. This highlights the need for future work to test the efficacy of preventive practices, designed to improve sleep at pre-symptomatic stages of disease, on reducing Alzheimer's disease pathology.

RF12 | PSUN118 Diet Quality and Energy Intake Mediate the Association of Food Insecurity with Adiposity

Abstract Food insecurity, the lack of consistent access to sufficient food for an active and healthy life, is associated with lower diet quality, higher BMI and adiposity, and poor metabolic health. Although lower diet quality is assumed to be responsible for the impact of food insecurity on adiposity, this hypothesis has not been previously investigated. To test the hypothesis that diet quality mediates the association of food insecurity with adiposity, we used data from the 2015-2016 National Health and Nutrition Examination Survey (NHANES, age ≥18 years, n=5821, weighted N=233,636,542). Anthropometrics included BMI, waist circumference and fat mass (measured by dual X-ray absorptiometry and expressed as percentage of total body weight). Food insecurity was assessed with the 10-item NHANES Food Security Survey Module and defined as ≥3 affirmative responses. Nutrition information was derived from 24h food recalls obtained on 2 separate occasions. Diet quality was estimated by the Healthy Eating Index-2015 (HEI), which includes a total score for overall diet quality, and sub-scores for several dietary components. Mediation analysis was conducted with the Baron and Kenny approach. A p-value &amp;lt;0.05 was considered statistically significant. The cohort included 52% women, 11% non-Hispanic Black and 15% Hispanic participants. Eighteen percent were food insecure. They reported a lower energy intake compared to food secure participants, although the difference was not significant after adjusting for demographics and income (difference [95% confidence interval] -84 [-207.36, 38.91] kcal/day, p=0.15). Total HEI and fruit scores were lower in food insecure individuals, suggesting lower diet quality (adjusted difference -1.70 [-3.09, -0.32], p=0.03; and -0.28 [-0.53, -0.02], p=0.04, respectively). Obesity was 22% more prevalent in food insecure individuals (p&amp;lt;0.01). Fat mass and waist circumference were also higher in individuals with food insecurity (adjusted difference 0.95 [0.19, 1.7] %, p=0.02; and 3.81 [1.3, 6.31] cm, p=0.01, respectively). Mediation analysis revealed that total energy intake mediated the effect of food insecurity on fat mass but not BMI or waist circumference, while total HEI partially mediated the effect of food insecurity on waist circumference but not BMI or percent fat mass. No mediation of total fruit score on BMI or adiposity was observed. In summary, our results confirm a greater prevalence of obesity and higher adiposity in food insecure individuals, despite a similar reported energy intake compared to food secure individuals. Energy intake and measures of diet quality appear to mediate some of the effect of food insecurity on overall and central adiposity, but not on BMI. This suggests that other factors, including the social determinants of health, may also play a role. Presentation: Saturday, June 11, 2022 1:18 p.m. - 1:23 p.m., Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.

SLEEP QUALITY AND AFFECTING FACTORS AMONG ELDERLY LIVING IN A NURSING HOME AT EAST NUSA TENGGARA INDONESIA

Sleep is one of the processes that greatly affects aging, It essential for mental, physical, and maintenance of physical health. Kupang East Nusa Tenggara, Indonesia, a research study in a nursing home of the elderly experience have a bad quality of sleep. This study aimed to analyze the sleep quality and the factors affecting, among old age living in a nursing home at East Nusa Tenggara Indonesia. The research design was cross-sectional with primary data on 103 elderly living in nursing homes. There was a relationship between age, gender, marital status, spouse, education background, have a chronic diseases, living arrangement, anxiety, and depression with sleep quality (p&lt;0.05). The correlation showed that there was a strong and positive patterned relationship (&lt;0.05) between the total anxiety score and the total sleep quality score (r=0.608) and the total depression score with the total sleep quality score (r=0.561) meaning that the higher of the elderly felt anxiety and depression worsened for the quality of sleep. Old age who lives alone are more susceptible to stress or depression resulting from unconvenient environment where they live. High levels of anxiety and depression in the elderly are associated with poorer sleep quality.