Objective. To evaluate the possibility of treating dyslipidemia with a medication containing red fermented rice, vitamins B3, B12, B6, B9, and coenzyme Q10. Patients and methods. The study included 24 male and female patients with dyslipidemia, the laboratory-confirmed changes in the lipid profile, which was assessed by the levels of total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triglycerides in blood tests. The treatment did not include dietary correction. All patients received a medication containing red fermented rice, vitamins B3, B12, B6, B9, and coenzyme Q10 for 6 months. The lipid profile was evaluated at three visits: before treatment and after 3 and 6 months. Data processing was performed using IBM SPSS Statistics 23.0 (USA) software package. Results. Before treatment, all 24 patients had changes in the lipid profile: total cholesterol levels ranged from 4.2 to 11.4 mmol/L, mean value – 6.6 ± 1.17 mmol/L; HDL levels from 0.7 to 2.4 mmol/L, mean value – 1.3 ± 0, 34 mmol/L; LDL levels from 2.2 to 5.9 mmol/L, mean value – 4.0 ± 0.95 mmol/L; triglyceride levels from 1.0 to 7.3 mmol/L, mean value – 2.2 ± 0.89 mmol/L. During 6 months of treatment, cholesterol levels decreased in 22 (92%) patients and ranged from 4.5 to 9.1 mmol/L, mean value – 5.09 ± 0.73 mmol/L (p < 0.01); no dynamics was observed in 1 (4%) patient, and 1 (4%) patient showed an increase in cholesterol levels. HDL levels increased in 21 (88%) patients and ranged from 1.0 to 2.5 mmol/L, mean value – 1.7 ± 0.28 mmol/L (p < 0.01); a decrease in HDL was observed in 3 (12%) patients. LDL levels decreased in 15 (63%) patients and ranged from 2.5 to 5.3 mmol/L, mean value – 3.7 ± 0.55 mmol/L (p < 0.01); in 9 (37%) patients, LDL increased. Triglyceride levels decreased in 23 (96%) patients and ranged from 0.7 to 3.3 mmol/L, mean value – 1.4 ± 0.43 mmol/L (p < 0.01); increased triglyceride levels were seen in 1 (4%) patient. Discussion. The correction of deficiencies of B vitamins and coenzyme Q10 showed a significant and clinically relevant decrease in the levels of total cholesterol, LDL and triglycerides and an increase in HDL. Conclusion. The medication containing B vitamins (pantothenic acid, pyridoxine, folic acid, cyanocobalamin), coenzyme Q10 and red fermented rice demonstrated its effectiveness in the treatment of dyslipidemia and can be used in clinical practice. Key words: dyslipidemia, coenzyme Q10, high-density lipoproteins, low-density lipoproteins, pantothenic acid, pyridoxine, triglycerides, folic acid, cholesterol, cyanocobalamin