Homeopathy medicines have been applied with positive results in agriculture, livestock and freshwater aquaculture. Commercial formulations such as Homeopatila™ have been successfully evaluated in Nile tilapia (Oreochromis niloticus) and Pacu (Piaractus mesopotamicus) with measurable effects on growth, survival, and immune response during culture, management and transport. The spotted rose snapper Lutjanus guttatus is a marine fish with meat of exceptional quality, and commercial importance because of its potential for marine aquaculture. To assess the value of homeopathy on health enhancement of the species, ten groups of 30 juveniles each (8.72 ± 4.07 g; 8.47 ± 1.24 cm) were cultivated for 30 days in 120 L fiberglass cylinders provided with continuous aeration and filtered (50 μm) seawater daily exchanged by 900%. An experimental design with five different treatments, each one with two replicates, was developed to determine the effect of three homeopathic mixes: Hel-Mix, Pav-Mix, and Hel-Mix/Pav-Mix, and two control groups: No-Medication (NM) and Ethanol 300GL (E). Homeopathic medicines (31CH) in treated groups and E in control group were sprayed (5% V/W) in commercial balanced food (Silvercup™) and supplied ad-libitum five times a day. Growth in total length and live weight was expressed as percentage increase. A significant (p These results suggest that homeopathic medicines have potential application in marine fish aquaculture. We recommend studying overall response of broodstock, larvae and juveniles treated with homeopathic medicines to improve hatchery operations from spawning to stocking size.