<p indent=0mm>The structure of the novel airfoil fin heat exchanger was optimized by the synergistic enhancement method based on the entransy matching performance, and two types of nonuniform fin distribution structures were proposed. The heat transfer and flow performance of various airfoil fin distribution structures were numerically studied by using supercritical CO<sub>2</sub> as the working medium under constant heat flux boundary conditions. The results showed that considering the extremely uneven distribution of heat transfer parameters arising from the drastic changes in the physical properties of supercritical fluid, the distribution of novel airfoil fins was changed under the condition that the total heat transfer area remained constant. The matching performance between the entransy of fluid and that of the wall heat flux was improved, and the distribution uniformity of the local entransy dissipation rate in the channel was improved. Hence, the total entransy dissipation rate in the channel was reduced, and the heat transfer performance was improved. The numerical studies under the boundary condition of variable heat flux in the two-fluid coupled heat transfer process showed that the distribution mode of the novel airfoil fins changed according to the distribution characteristics of heat transfer parameters in the two-fluid coupled heat exchanger. Under the condition that the total heat transfer area remained constant, the distribution matching of the entransy of hot and cold fluid also improved, so that the local entransy dissipation rate was more uniform in the heat transfer area, and the entransy dissipation rate was reduced. The entransy distribution-matching principle provides a new idea and method for the structural optimization and improvement of heat exchangers, which has important theoretical and engineering significance.