Abstract This article conducts an in-depth study of the application of LED (Light-Emitting Diode) lamps in nuclear power plant lighting systems and conducts a comprehensive analysis of its impact on the power quality of the plant’s low-voltage AC power system. First of all, through a detailed discussion of the harmonic characteristics of LED lamps and the power quality requirements of nuclear power plants, it is pointed out that the harmonics of LED lamp drivers will inevitably have an impact on the power quality of low-voltage AC power systems. Therefore, the harmonic characteristics of LED lamps must comply with certain constraints. Subsequently, the application of LED lamps under different capacity transformers was analyzed and combined with relevant standards and specifications, and application suggestions for LED lamps in nuclear power plant lighting systems were put forward. Finally, measures to improve the total harmonic distortion rate of LED lamp current were discussed, emphasizing the importance of power factor correction technology. In summary, this article provides important reference and guidance for the application of LED lamps in nuclear power plants, helping to ensure the safe and stable operation of nuclear power plants.