Five young adult male subjects with normal larynxes were recorded as they sustained phonation during one normal and three drug conditions. The vocal tasks included obtaining the total fundamental frequency range, tone-matching ability, and vocal fry production, and were performed by the subject (1) before drugs, (2) following injection of a tranquilizer-narcotic premedication, (3) after topical anesthesia of the larynx, and (4) during a drug-recovery period. Results showed no significant differences between conditions on any of the measures of sustained phonation. It was concluded that neither depressed cortical function nor sensory deprivation of the laryngeal mucosa alters the subject’s phonatory capabilities essential to the performance of the selected vocal tasks.