This study investigates the effect of quality of resosurces on Total Factor Productivity of enterprises in Vietnam. Using neo-classical growth theory of Solow (1956), we hypothesize that quality of capital and labor is positively related to Total Factor Productivity of enterprises in Vietnam. The study uses the survey data extracted from the Enterprise Survey data set of World Bank in 2015 and 2009 to test the proposed hypotheses. OLS regression shows that our hypothesis is strongly supported under controlling the characteristics of enterprises.