In this research, as part of working towards improving the IRI over equatorial region, the total electron content (TEC) derived from GPS measurements and IRI-2007 TEC predictions at Chumphon station (10.72°N,99.37°E), Thailand, during 2004–2006 is analyzed. The seasonal variation of the IRI-2007 TEC predictions is compared with the TEC from the IRI-2007 TEC model with the option of the actual F2 plasma frequency (foF2) measurements as well as the TEC from the GPS and International GNSS service (IGS). The Chumphon station is located at the equatorial region and the low latitude of 3.22°N. For a declining phase of the solar cycle (2004–2006), the study shows that the IRI-2007 TEC underestimates the IRI-2007 TEC with the foF2 observation at the nighttime by about 5 TECU. The maximum differences are about 15 TECU during daytime and 5 TECU during nighttime. The overestimation is more evident at daytime than at nighttime. When compared in terms of the root-mean square error (RMSE), we find that the highest RMSE between GPS TEC and IRI 2007 TEC is 14.840 TECU at 1230 LT in 2004 and the lowest average between them is 1.318 TECU at 0630 LT in 2006. The noon bite-out phenomena are clearly seen in the IRI-2007 TEC with and without optional foF2 measurements, but not on the GPS TEC and IGS TEC. The IRI TEC with optional foF2 measurements gives the lowest RMSE values between IRI TEC predicted and TEC measurement. However, the TEC measurements (GPS TEC and IGS TEC) are more correct to use at Chumphon station.