The experimental site was carried out at Agricultural College and Research Institute, TNAU, Coimbatore, during Rabi season of 2018-19 to evaluate the pre and post-emergence herbicides on weed control and yield of irrigated sesame (Sesamum indicum L.). The experiment was laid out in Randomized Complete Block Design with three replications. The results of the experiment concluded that application of pendimethalin at 750g ha-1 as pre-emergence followed by one-hand weeding at 30 days after sowing documented lower total weed density and higher weed control efficiency compared to other treatments and also found superior seed yield (843 kg ha-1). In addition, non-availability of pre-emergence herbicide at the appropriate time, application of early post- emergence of imazythapyr 35 a.e. + imazamox 35 a.e. @ 30 g a.i. ha-1 with hand weeding on 40 days after sowing was found to be better than hand weeding twice at 20 and 40 days after sowing.