Total Conductance Research Articles

Peptide-induced membrane elastic deformations decelerate gramicidin dimer-monomer equilibration

Gramicidin A (gA) is a hydrophobic pentadecapeptide readily incorporating into a planar bilayer lipid membrane (BLM), thereby inducing a large macroscopic current across the BLM. This current results from ion-channel formation due to head-to-head transbilayer dimerization of gA monomers with rapidly established monomer-dimer equilibrium. Any disturbance of the equilibrium, e.g., by sensitized photoinactivation of a portion of gA monomers, causes relaxation toward a new equilibrium state. According to previous studies, the characteristic relaxation time of the gA-mediated electric current decreases as the current increases upon elevating the gA concentration in the membrane. Here, we report data on the current relaxation kinetics for gA analogs with N-terminal valine replaced by glycine or tyrosine. Surprisingly, the relaxation time increased rather than decreased upon elevation of the total membrane conductance induced by these gA analogs, thus contradicting the classical kinetic scheme. We developed a general theoretical model that accounts for lateral interaction of monomers and dimers mediated by membrane elastic deformations. The modified kinetic scheme of the gramicidin dimerization predicts the reverse dependence of the relaxation time on membrane conductance for gA analogs, with a decreased dimerization constant that is in a good agreement with our experimental data. The equilibration process may be also modulated by incorporation of other peptides (“impurities”) into the lipid membrane.

Speed Gradient Control Algorithm for Optogenetic Modeling

We discuss the feedback algorithm for the optogenetic control over the membrane conductance in the frame of Grossman-Nikolic-Toumazou-Degenaar (GNTD) ordinary differential system modeling the response of channelrhodopsin-2 (ChR2) expressing neurons to the light stimulation with the various types of ChR2 mutants. The GNTD population dynamics contains four functional states (two open and two closed) with the transitions among them due to photo-excitations with the stimulating light or decays back from the open to the closed states. The control signal in the model is defined via the photon flux per one ChR2 in the dimensionless form. The control goal is the total conductance of a neural section due to ChR2. We formulate the control algorithm in the form of Fradkov’s speed gradient method driving the dynamical system in the phase space such that the target function for the discrepancy between the actual total conductance and its desired level is minimized. We derive the explicit equation for the photon flux field stabilizing the conductance characteristics and perform the numerical simulation for the controlled GNTD differential system to prove the achievability of the control goal. Our approach can be useful for modeling different experimental problems of optogenetics, particularly, for driving the collective dynamics of neural cells in epilepsy, depression, and tumors of the central nervous system.

Ultrahigh Spin Filter Efficiency, Giant Magnetoresistance and Large Spin Seebeck Coefficient in Monolayer and Bilayer Co-/Fe-/Cu-Phthalocyanine Molecular Devices.

The spin related electrical and thermoelectric properties of monolayer and bilayer MPc (M = Co, Fe, Cu) molecular devices in a parallel spin configuration (PC) and an anti-parallel spin configuration (APC) between the V-shaped zigzag-edged graphene nanoribbon electrodes and the center bilayer MPc molecules are investigated by combining the density functional theory and non-equilibrium Green’s function approaches. The results show that there is an ultrahigh spin filter efficiency exceeding 99.99995% and an ultra-large total conductance of 0.49996G0 for FePc-CoPc molecular devices in the PC and a nearly pure charge current at high temperature in the APC and a giant MR ratio exceeding 9.87 × 106% at a zero bias. In addition, there are pure spin currents for CuPc and FePc molecular devices in the PC, and an almost pure spin current for FePc molecular devices in the APC at some temperature. Meanwhile, there is a high SFE of about 99.99585% in the PC and a reserved SFE of about −19.533% in the APC and a maximum MR ratio of about 3.69 × 108% for the FePc molecular device. Our results predict that the monolayer and bilayer MPc (M = Co, Fe, Cu) molecular devices possess large advantages in designing high-performance electrical and spintronic molecular devices.

Transport properties in gapped bilayer graphene

We investigate transport properties through a rectangular potential barrier in AB-stacked bilayer graphene (AB-BLG) gapped by dielectric layers. Using the Dirac-like Hamiltonian with a transfer matrix approach we obtain transmission and reflection probabilities as well as the associated conductance. For two-band model and at normal incidence, we find extra resonances appearing in transmission compared to biased AB-BLG, which are Fabry-P\'erot resonance type. Now by taking into account the inter-layer bias, we show that both of transmission and anti-Klein tunneling are diminished. Regarding four band model, we find that the gap suppresses transmission in an energy range by showing some behaviors look like "Mexican hats". We examine the total conductance and show that it is affected by the gap compared to AA-stacked bilayer graphene. In addition, we find that the suppression in conductance is more important than that for biased AB-BLG.

Partitioning evapotranspiration based on the total ecosystem conductance fractions of soil, interception, and canopy in different biomes

Partitioning evapotranspiration (ET) into soil evaporation (Esoil), canopy interception evaporation (Eic), and transpiration (T) yields both comprehensive insight into hydrological processes and better water management, but it is challenging. This study proposes a modified ecosystem conductance-based Priestley-Taylor (MEC-PT) algorithm for ET partitioning based on the total ecosystem conductance (GTotal) fractions of soil, interception, and canopy. Datasets from 24 flux towers around the world were used to estimate GTotal by coupling aerodynamic conductance and surface conductance (Gs). Results from the MEC-PT model were compared with those from an original best-fit ecosystem-level conductance (m-order) model that only partitions Gs into soil and canopy domains. The superior performance of the MEC-PT model, with the inclusion of an intercepted contributor and ability to fill the data gap associated with the m-order during wet conditions, describes the robustness of this approach for partitioning ET. The MEC-PT model results might reflect dew formation that produces minimal Eic volume under non-rainfall conditions with support from the diurnal temperature (DT) presence. The ratio of T to total ET (T/ET) was found highest in forest with 0.72 (±0.17 of standard deviation), followed by savanna (0.57 ± 0.11), cropland (0.48 ± 0.10), and grassland (0.39 ± 0.17). Also, sensitivity analysis was conducted with main input variables of the MEC-PT and m-order models over four land cover types and the whole study period of each site used in this study. The results demonstrated that, in general conditions, net radiation was the key driver controlling T/ET variations, whereas air temperature and wind speed indirectly and slightly affected T/ET. This study underlines that the inclusion of Eic might bridge the gap in knowledge about ET and its components regarding canopy dynamics and ecosystem behaviors in the context of climate change.

Effects of different electrical arrangements and Thomson effect on the system performance as well as the optimum allocation of thermocouples in a self-driven two-stage TEC & TEG

In this study, four different electrical arrangements of a two-stage thermoelectric cooler (TEC) driven by a two-stage thermoelectric generator (TEG) are analyzed, and the best combination is identified in terms of maximum cooling capacity and coefficient of performance (COP). The results demonstrate that the inclusion of the Thomson effect increases the maximum COP and cooling capacity and shifts the optimum thermocouple ratio towards a lower value. Simple regression equations are developed for quick and accurate prediction of optimum thermocouples ratio for maximum cooling capacity and maximum COP conditions. As observed, the optimum thermocouple ratio is a strong function of total thermal conductance, source and sink temperatures, thermocouple ratio in stages of TEG and TEC and the type of electrical arrangement. The best combination is further confirmed by analyzing the variation of exergetic efficiency with the total thermocouple ratio. Although both the arrangement, i.e. TEG in parallel and TEC in series and TEG in series and TEC in series, yield comparable COP, TEG in parallel and TEC in series is quite advantageous from the cooling capacity point of view. In the absence of the Thomson effect, TEG in parallel TEC in series yields the best COP and cooling capacity.

High-Temperature Skin Softening Materials Overcoming the Trade-Off between Thermal Conductivity and Thermal Contact Resistance.

The trade-off between thermal conductivity (κ) and thermal contact resistance (Rc ) is regarded as a hurdle to develop superior interface materials for thermal management. Here a high-temperature skin softening material to overcome the trade-off relationship, realizing a record-high total thermal conductance (254.92 mW mm-2 K-1 ) for isotropic pad-type interface materials is introduced. A highly conductive hard core is constructed by incorporating Ag flakes and silver nanoparticle-decorated multiwalled carbon nanotubes in thermosetting epoxy (EP). The thin soft skin is composed of filler-embedded thermoplastic poly(ethylene-co-vinyl acetate) (PEVA). The κ (82.8 W m-1 K-1 ) of the PEVA-EP-PEVA interface material is only slightly compromised, compared with that (106.5 W m-1 K-1 ) of the EP core (386µm). However, the elastic modulus (E= 2.10GPa) at the skin is significantly smaller than the EP (26.28GPa), enhancing conformality and decreasing Rc from 108.41 to 78.73 mm2 K W-1 . The thermoplastic skin is further softened at an elevated temperature (100°C), dramatically decreasing E (0.19GPa) and Rc (0.17 mm2 K W-1 ) with little change in κ, overcoming the trade-off relationship and enhancing the total thermal conductance by 2030%. The successful heat dissipation and applicability to the continuous manufacturing process demonstrate excellent feasibility as future thermal management materials.

Cuticular conductance of adaxial and abaxial leaf surfaces and its relation to minimum leaf surface conductance

Cuticular conductance to water (gcw ) is difficult to quantify for stomatous surfaces due to the complexity of separating cuticular and stomatal transpiration, and additional complications arise for determining adaxial and abaxial gcw . This has led to the neglect of gcw as a separate parameter in most common gas exchange measurements. Here, we describe a simple technique to simultaneously estimate adaxial and abaxial values of gcw , tested in two amphistomatous plant species. What we term the 'Red-Light method' is used to estimate gcw from gas exchange measurements and a known CO2 concentration inside the leaf during photosynthetic induction under red light. We provide an easy-to-use web application to assist with the calculation of gcw . While adaxial and abaxial gcw varies significantly between leaves of the same species we found that the ratio of adaxial/abaxial gcw (γn ) is stable within a plant species. This has implications for use of generic values of gcw when analysing gas exchange data. The Red-Light method can be used to estimate total cuticular conductance (gcw-T ) accurately with the most common setup of gas exchange instruments, i.e. a chamber mixing the adaxial and abaxial gases, allowing for a wide application of this technique.

Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.

What is the central question of this study? Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady-state hypoxaemia, whereas men do not? What is the main finding and its importance? Sympathetically mediated vasoconstriction is preserved or even enhanced during steady-state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex-related differences in hypoxic vascular control. Activation of the sympathetic nervous system causes vasoconstriction and a reduction in peripheral blood flow. Sympathetically mediated vasoconstriction may be attenuated during systemic hypoxia to maintain oxygen delivery; however, in predominantly male participants sympathetically mediated vasoconstriction is preserved or even enhanced during hypoxaemia. Given the potential for sex-specific differences in hypoxic vascular control, prior results are limited in application. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady-state hypoxaemia, whereas men do not. Healthy young men (n=13, 25±4years) and women (n=11, 24±4years) completed two trials consisting of a 2-min cold pressor test (CPT, a well-established sympathoexcitatory stimulus) during baseline normoxia and steady-state hypoxaemia. Beat-to-beat blood pressure (finger photoplethysmography) and forearm blood flow (venous occlusion plethysmography) were measured continuously. Total and forearm vascular conductance (TVC and FVC, respectfully) were calculated. A change (Δ) in TVC and FVC from steady-state during the last 1min of CPT was calculated and differences between normoxia and systemic hypoxia were assessed. In men, the reduction in TVC during CPT was greater during hypoxia compared to normoxia (ΔTVC, P=0.02), whereas ΔTVC did not differ between conditions in women (P=0.49). In men, ΔFVC did not differ between normoxia and hypoxia (P=0.92). In women, the reduction in FVC during CPT was attenuated during hypoxia (ΔFVC, P<0.01). We confirm sympathetically mediated vasoconstriction is preserved or enhanced during hypoxaemia in young men, whereas peripheral vascular responsiveness to sympathetic activation during hypoxaemia is attenuated in young women. The results advance our understanding of sex-related differences in hypoxic vascular control.

Role of dephasing on the conductance signatures of Majorana zero modes

Conductance signatures that signal the presence of Majorana zero modes in a three terminal nanowire-topological superconductor hybrid system are analyzed in detail, in both the clean nanowire limit and in the presence of non-coherent dephasing interactions. In the coherent transport regime for a clean wire, we point out contributions of the local Andreev reflection and the non-local transmissions toward the total conductance lineshapes while clarifying the role of contact broadening on the Majorana conductance lineshapes at the magnetic field parity crossings. Interestingly, at larger B-field parity crossings, the contribution of the Andreev reflection process decreases which is compensated by the non-local processes in order to maintain the conductance quantum regardless of contact coupling strength. In the non-coherent transport regime, we include dephasing that is introduced by momentum randomization processes, that allows one to smoothly transition to the diffusive limit. Here, as expected, we note that while the Majorana character of the zero modes is unchanged, there is a reduction in the conductance peak magnitude that scales with the strength of the impurity scattering potentials. Dephasing due to fluctuating impurities is shown to affect the conductance lineshapes in ways that are distinguishable from the effects of contact-induced tunnel broadening. Most importantly our results reveal that the addition of dephasing in the set up does not lead to any notable length dependence to the conductance of the zero modes, contrary to what one would expect in a gradual transition to the diffusive limit. We believe this work paves a way for a systematic introduction of scattering processes into the realistic modeling of Majorana nanowire hybrid devices and assessing topological signatures in such systems in the presence of non-coherent scattering processes.

Supercritical CO2 Binary Mixtures for Recompression Brayton s-CO2 Power Cycles Coupled to Solar Thermal Energy Plants

In this work, an evaluation and quantification of the impact of using mixtures based on supercritical carbon dioxide “s-CO2” (s-CO2/COS, s-CO2/H2S, s-CO2/NH3, s-CO2/SO2) are made as a working fluid in simple and complex recompression Brayton s-CO2 power cycle configurations that have pressure drops in their components. These cycles are coupled with a solar thermal plant with parabolic-trough collector (PTC) technology. The methodology used in the calculation performance is to establish values of the heat recuperator total conductance (UAtotal) between 5 and 25 MW/K. The main conclusion of this work is that the cycle’s efficiency has improved due to using s-CO2 mixtures as working fluid; this is significant compared to the results obtained using the standard fluid (pure s-CO2). Furthermore, a techno-economic analysis is carried out that compares each configuration’s costs using pure s-CO2 and a mixture of s-CO2/COS with a molar fraction (70/30), respectively, as working fluid where relevant results are obtained. These results show that the best configuration in terms of thermal efficiency and cost is the RCC-RH for pure sCO2 with values of 41.25% and 2811 $/kWe, while for the mixture sCO2/COS, the RCC-2RH configuration with values of 45.05% and 2621 $/kWe is optimal. Using the mixture costs 6.75% less than if it is used the standard fluid (s-CO2).

Imbalance between nitrogen and potassium fertilization influences potassium deficiency symptoms in winter oilseed rape (Brassica napus L.) leaves

Chlorosis at leaf margins is a typical symptom of potassium (K) deficiency, but inappropriate application of K with other nutrients often masks symptoms of K deficiency. A two-year field experiment was conducted to measure the interactive effects of N and K on leaf photosynthesis and dry matter accumulation and the resulting growth dilution effect on K concentration and leaf K deficiency symptoms. N application aggravated the imbalance of N and K nutrients and further exacerbated K deficiency symptoms under K limitation. Synergistic effects of N and K promoted plant growth, amplified the growth dilution effect, and reduced the critical K concentration in leaves. Using 90% of the maximum shoot biomass as a threshold, the critical K concentration was 0.72% at the recommended N (N180) fertilization level. The critical K concentration increased by 62.5% owing to the reduced biomass under insufficient N (N90) supply. In contrast, high N (N270) reduced the critical K concentration (0.64%), accelerating chlorophyll decomposition and exacerbating K deficiency symptoms. The basis of changing the critical K concentration by magnifying growth dilution effect was the functional synergistic effect of N and K on photosynthetic characteristics. Under insufficient N, the low maximum carboxylation rate (Vcmax) limited the net photosynthetic rate (An) and necessitated more K to maintain high CO2 transmission capacity, to improve the total conductance gtot /Vcmax ratio. High N supply increased gtot and Vcmax, possibly mitigating the effect of K reduction on photosynthesis. In conclusion, it is unwise to judge K status of plants only by K concentration without accounting for crop mass (or dilution effect), critical K concentration and deficiency symptoms are affected by N fertilization, and the synergistic effect of N and K on leaf photosynthesis is the foundation of maximal growth of plants under diverse critical K concentrations.

Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/overweight males during submaximal exercise

ABSTRACT We investigated the effect of chronic grape seed extract (GSE) on blood pressure and aortic stiffness (AoS) among overweight and obese males. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS were measured during two submaximal cycling exercises (40% and 60% VO2max), after 7 consecutive days of GSE or placebo (PL) ingestion with one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest (85 ± 3 mmHg vs. 82 ± 3 mmHg), 40% (102 ± 3 mmHg vs. 99 ± 3 mmHg), and 60% workloads (109 ± 3 mmHg vs. 107 ± 3 mmHg) (P = 0.001, ES = 0.2). AoS was significantly reduced (13.0 ± 1.9 AU vs. 10.2 ± 1.0 AU) at rest (P = 0.002, ES = 0.6). Q was decreased at rest and across all workloads, but there were no significant differences (7.5 ± 0.4 L/min vs. 7.1 ± 0.4 L/min; 20.4 ± 1.2 L/min vs. 19.6 ± 0.9 L/min; 26.3 ± 1.1 L/min vs. 25.5 ± 1.6 L/min, respectively). GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the substantial reduction in AoS. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise. Trial registration: ClinicalTrials.gov identifier: NCT04465110.

Sympathetic Transduction During Euglycemic‐Hyperinsulinemia in Humans

Insulin plays an important role in post-prandial blood pressure (BP) regulation. Within the central nervous system insulin acts to stimulate sympathetic outflow to skeletal muscle. Concurrently, insulin acts locally in the periphery to promote vasodilation and is suggested to also attenuate sympathetically-mediated vasoconstriction. Given these divergent actions, the ‘net effect’ of insulin on the sympathetic control of BP remains incompletely understood. Therefore, the purpose of this study was to examine the effect of hyperinsulinemia on sympathetic transduction to BP. To accomplish this, in 10 young healthy men, heart rate (ECG), BP (finometer or brachial arterial line) and muscle sympathetic nerve activity (MSNA) were measured at rest and during euglycemic-hyperinsulinemia. Signal-averaging was used to characterize the changes in mean arterial pressure (MAP) and total vascular conductance (TVC; derived from ModelFlow) over 10 cardiac cycles following spontaneous bursts of MSNA at rest and during hyperinsulinemia. No significant differences were found in the peak MAP (Rest: ∆2.8 ± 0.3; Insulin: ∆2.4 ± 0.2 mmHg, P=0.15) or TVC (Rest: ∆-3.0 ± 0.4; Insulin: ∆-2.7 ± 0.5 mL/min/mmHg, P=0.38) responses following bursts of MSNA between rest and hyperinsulinemia (i.e., ‘net’ sympathetic transduction was unchanged). Notably, the average size of normalized MSNA bursts was increased during hyperinsulinemia (Rest: 45.6 ± 1.8; Insulin 65.3 ± 5.0 Au, P<0.01). To take into account changes in burst height, MSNA bursts were divided into amplitude-matched bins. When MSNA burst amplitude bins were matched between rest and hyperinsulinemia, sympathetic transduction for a given burst amplitude was blunted during insulin infusion (e.g., largest resting bursts: MAP, Rest: ∆4.4 ± 0.5; Insulin: ∆3.0 ± 0.3 mmHg, P=0.02; TVC, Rest: ∆-5.2 ± 0.8; Insulin: ∆-3.1 ± 0.7 mL/min/mmHg, P=0.05). However, it is important to note that 15 ± 5% of MSNA bursts exhibited amplitudes greater than that which existed at rest and overall during hyperinsulinemia ~50% of all MSNA bursts were comparable or greater in amplitude to the largest bursts present at rest. Collectively, these preliminary findings suggest that during hyperinsulinemia, sympathetic transduction for a given burst amplitude is attenuated while ‘net’ sympathetic transduction remains unchanged due to the generation of larger MSNA bursts.

Power and Thermal Efficiency Optimization of an Irreversible Steady-Flow Lenoir Cycle.

Using finite time thermodynamic theory, an irreversible steady-flow Lenoir cycle model is established, and expressions of power output and thermal efficiency for the model are derived. Through numerical calculations, with the different fixed total heat conductances () of two heat exchangers, the maximum powers (), the maximum thermal efficiencies (), and the corresponding optimal heat conductance distribution ratios () and () are obtained. The effects of the internal irreversibility are analyzed. The results show that, when the heat conductances of the hot- and cold-side heat exchangers are constants, the corresponding power output and thermal efficiency are constant values. When the heat source temperature ratio () and the effectivenesses of the heat exchangers increase, the corresponding power output and thermal efficiency increase. When the heat conductance distributions are the optimal values, the characteristic relationships of and are parabolic-like ones. When is given, with the increase in , the , , , and increase. When is given, with the increase in , and increase, while and decrease.

Modeling and operation optimization of an integrated ground source heat pump and solar PVT system based on heat current method

Multisource cleaning energy supply is a significant solution for reducing carbon emission and achieving carbon neutral. This paper proposed an integrated ground source heat pump-photovoltaic-thermal (GSHP-PVT) system to achieve the combined clean heating/cooling, reduce the heat transfer irreversible loss, and increase the flexibility of the system by introducing double-evaporators with different working fluids. According to the heating or cooling in day or night, we proposed five kinds of operation modes of the system in the annual year in winter, summer, and other seasons. Moreover, we applied the heat current method for constructing the overall heat current models of each operation mode. On this basis, the minimum of the total input work of the system can obtain the optimal mass flow rate allocation in each component under five operation modes. The optimization results show that the COP of the GSHP-PVT system always remains between 4 and 6 in the annual year. Meanwhile, the proposed system can effectively prevent the ground source's temperature decrease and operate with high efficiency. Besides, the increase of the total thermal conductance of this system, the PVT collector areas, and the temperature of water-antifreeze flowing out of the PVT collector can effectively improve the overall performance of the proposed system.

Engineering adjustable two-pore devices for parallel ion transport and DNA translocations.

We report ionic current and double-stranded DNA (dsDNA) translocation measurements through solid-state membranes with two TEM-drilled ∼3-nm diameter silicon nitride nanopores in parallel. Nanopores are fabricated with similar diameters but varying in effective thicknesses (from 2.6 to 10 nm) ranging from a thickness ratio of 1:1 to 1:3.75, producing distinct conductance levels. This was made possible by locally thinning the silicon nitride membrane to shape the desired topography with nanoscale precision using electron beam lithography (EBL). Two nanopores are engineered and subsequently drilled in either the EBL-thinned or the surrounding membrane region. By designing the interpore separation a few orders of magnitude larger than the pore diameter (e.g., ∼900 vs 3 nm), we show analytically, numerically, and experimentally that the total conductance of the two pores is the sum of the individual pore conductances. For a two-pore device with similar diameters yet thicknesses in the ratio of 1:3, a ratio of ∼1:2.2 in open-pore conductances and translocation current signals is expected, as if they were measured independently. Introducing dsDNA as analytes to both pores simultaneously, we detect more than 12 000 events within 2 min and trace them back with a high likelihood to which pore the dsDNA translocated through. Moreover, we monitor translocations through one active pore only when the other pore is clogged. This work demonstrates how two-pore devices can fundamentally open up a parallel translocation reading system for solid-state nanopores. This approach could be creatively generalized to more pores with desired parameters given a sufficient signal-to-noise ratio.

Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction.

The current study evaluated the influence of resting muscle sympathetic nerve activity (MSNA) burst size and firing pattern on time-to-peak sympathetic transduction in 36 young healthy men and women. Participants underwent a 5-10 min resting baseline with beat-to-beat measures of heart rate, mean arterial pressure (MAP), and MSNA (microneurography). Cardiac output and total vascular conductance were calculated using the Modelflow algorithm. Sympathetic transduction was quantified using the burst-triggered signal averaging technique to examine the changes in MAP, cardiac output, and total vascular conductance for 15 cardiac cycles after each MSNA burst or non-burst. A stepwise increase in the peak MAP (i.e., sympathetic transduction) was observed throughout all quartiles of normalized MSNA burst area (quartile 1 (Q1): 1.7 ± 1.3 mm Hg; Q2: 2.1 ± 1.3 mm Hg; Q3: 2.6 ± 1.4 mm Hg; Q4: 3.5 ± 1.4 mm Hg; P < 0.01). The largest quartile of normalized MSNA burst area demonstrated faster time-to-peak MAP responses (5.7 ± 2.5 s) than both Q1 (10.1 ± 3.9 s, P < 0.01) and Q2 (9.3 ± 4.1 s, P < 0.01), as well as, faster time-to-peak cardiac output and time-to-nadir total vascular conductance compared with Q1 and Q2 (All P < 0.05). Larger clusters of sympathetic bursts (i.e., triplets and ≥ quadruplets) did not have increased time-to-peak transduction compared with singlets and doublet bursts across all MSNA quartiles. These results highlight intraindividual variability in the time-course of sympathetic transduction and reveal an intrinsic property of larger sympathetic bursts to increase time-to-peak sympathetic transduction in humans. Novelty: Muscle sympathetic burst size can modulate time-to-peak sympathetic transduction in young healthy men and women. These observations appear independent of the pattern of sympathetic firing.

Application of geographical information system to geoelectrical data for evaluation of the vulnerability of aquifers in parts of Bauchi, Northeastern Nigeria

The poor quality and inconsistent nature of most surface water supply in arid and semi-arid regions of the world has increased the reliance on groundwater resources. However, the susceptibility of groundwater to anthropogenic pollution in most cities and rural communities in Nigeria has become a major source of concern. In this study, the protective capacity of the aquifers in parts of the Bauchi State, Northeastern, Nigeria, from surface contamination was investigated in light of the geoelectrical characteristics of the overburden materials for sustainable management of the resources. This study applied a geographical information system (GIS) technique to secondary geoelectrical parameters (Dar-Zarrouk) derived from 94 vertical electrical soundings (VES) to delineate aquifer vulnerability zones. Five different thematic maps (topsoil longitudinal unit conductance, total overburden longitudinal unit conductance, total transverse unit resistance, coefficient of anisotropy, and total overburden isopach) were developed. Suitable weights were assigned to the thematic maps based on their relative influence on the protection of groundwater systems in the area. Subsequently, the ranks of the subclasses of the themes were reclassified based on their respective suitability before the thematic maps were integrated using ArcGIS 10.3 software to generate the overall aquifer protective capacity map of the study area. To validate the map, water samples were collected from 40 wells and trace elements (e.g., Ni, Cu, Sb, Cr, and As) were analyzed. The study area was categorized into three aquifer vulnerability zones: moderate (32.4%), weak/fair (54.5%), and low/poor (13.1%). Moderate zones with limited portions of fair/weak zones were the predominant zones within the basement setting. This reflects the occurrence of clayey saprolitic units within the basement terrain ( 15,000 Ωm2). Over 60% of the basement settings are characterized by moderate aquifer protective capacity. On the other hand, the sedimentary zones due to weak and poor protective capacity zones are more vulnerable to pollution. The trace elemental analysis shows the predominance of As, Cu, and Sb in the sedimentary zones as compared to the basement setting which corroborates the aquifer protective capacity map produced.

Thermal transport across wrinkles in few-layer graphene stacks.

Wrinkles significantly influence the physical properties of layered 2D materials, including graphene. In this work, we examined thermal transport across wrinkles in vertical assemblies of few-layer graphene crystallites using the Raman optothermal technique supported by finite-element analysis simulations. A high density of randomly oriented uniaxial wrinkles were frequently observed in the few-layer graphene stacks which were grown by chemical vapor deposition and transferred on Si/SiO2 substrates. The thermal conductivity of unwrinkled regions was measured to be, κ ∼ 165 W m−1 K−1. Measurements at the wrinkle sites revealed local enhancement of thermal conductivity, with κ ∼ 225 W m−1 K−1. Furthermore, the total interface conductance of wrinkled regions decreased by more than an order of magnitude compared to that of the unwrinkled regions. The physical origin of these observations is discussed based on wrinkle mediated decoupling of the stacked crystallites and partial suspension of the film. Wrinkles are ubiquitous in layered 2D materials, and our work demonstrates their strong influence on thermal transport.