Abstract Objective To improve fracture treatment, in vitro experiments were performed to study the influence of a full limb cast and a walking cast on the loading regimen of bones in the distal portion of the equine forelimb. Animals 6 forelimbs of 6 Shetland ponies. Procedure Loading of the third metacarpal bone was considered a representative measure for distal limb loading. Electrical resistance rosette strain gauges were attached to the dorsal, palmar, medial, and lateral surfaces of the midshaft of this bone in 6 forelimbs of 6 Shetland ponies. The limbs were tested in a pneumatic loading device to a maximal load of 1,500 N. Results Both casts decreased the amount of compressive forces acting on the metacarpal bone. Application of a full limb cast resulted in a variable and eccentric decrease, remaining strains ranging from 84 to 7% of the baseline value. A walking cast was superior in that it gave a centric and more uniform reduction of compressive loading to <11 % of the baseline value. Moreover, a walking cast neutralized the bending and torsion components of the loading. Conclusion This study confirmed the clinical experience that a walking cast creates more reliable and favorable conditions for healing of fractures than does a full limb cast. (Am J Vet Res 1996;57:1386-1389)