The modified N50 austenitic stainless steel has been determined to be applied as the superconducting magnet supporting material of the Chinese Fusion Engineering Test Reactor (CFETR), especially the jacket material of the CICCs of both the TF coils and the CS coils and the case material of the TF coils, which inevitably requires welding connection. The welding process generally results in welding defects as well as degradation of cryogenic mechanical properties of metallurgical inhomogeneous zones. However, limited research has been reported to demonstrate the distinct localized performance of these zones at cryogenic temperature. The present paper presents an approach to characterize localized mechanical properties of the modified N50 welds at both room temperature (300 K) and cryogenic temperature (6 K). We identified the welding zone (WZ) through metallographic analysis and then the boundaries of the heat-affected zone (HAZ) were recognized by hardness measurements at room temperature. Finally, the localized optical digital image correlation (DIC) technique was used to obtain the localized yield strength Rp0.2 and percentage extension e of the WZ, the HAZ, and the base metal (BM) at both room and cryogenic temperature, of which the observed trend is verified through comparison with that of hardness measurements at room temperature. The technique proposed provides the localized measurement of cryogenic tensile properties of weld metals and also presents experimental data on different zones of the modified N50 welded joints as a jacket material for the next-generation fusion reactors.