To optimize the frame of a sightseeing vehicle, this paper proposes a multi-objective topology optimization method combining Analytic Hierarchy Process (AHP) and topology optimization. Firstly, the edges of the unmanned sightseeing car are statically analyzed. The rectangular steel frame structure of the original frame is replaced with square plates, the basic model of the unmanned sightseeing car frame is established, and a single-objective topology optimization mathematical model of the frame is established to optimize the topology design of the frame. Then, in order to design a frame structure that meets all the working conditions at the same time, a mathematical model of multi-working condition topology optimization is established, and the weights of each working condition are determined by using AHP, and the multi-working condition topology optimization design of the frame is carried out. Finally, a comparison of the comprehensive performance of the frame before and after optimization shows that the proposed method enables the optimized frame to meet the strength requirements under various working conditions, resulting in a weight reduction of 16.5 kg.