Objective. Comparative analysis of data on various plant extracts and their components, characterized by antitumor and antiinflammatory effects. Materials and methods. Systematic data analysis using topological recognition theory methods, clinical study of patients with fibrocystic mastopathy (FCM). Results. The analysis showed that the anti-inflammatory, antioxidant and antitumor properties of extracts of oleander, hauttuynia cordata, mistletoe, bitter melon, ginkgo biloba, grape seeds, cohosh, chasteberry and common spruce may be useful in the treatment of mastopathy and the prevention of breast cancer. A new class of candidate molecules with special antitumor properties, resinol lignans, has been isolated from Norway spruce extracts. In particular, 7-hydroxymatairesinol can be used for FCM, accompanied by various manifestations of menopausal syndrome, incl. mastalgia. The presented results of the original clinical study showed that during therapy with FCM 7-hydroxymatairesinol, there was a decrease or complete disappearance of menopausal syndrome, pain in the mammary glands and other symptoms. Positive dynamics of estrogen metabolites, their ratios and blood lipid profile indicators were noted, indicating normalization of estrogen metabolism. According to ultrasound data, after therapy with 7-hydroxymatairesinol, a decrease in the number and size of cystic formations in FCM was noted. Conclusion. Despite the fact that lignans from spruce extracts are the least studied, this group of compounds is promising for use in FCM to normalize estrogen metabolism and reduce fibrocystic changes in the mammary glands. Key words: phytoextracts, fibrocystic mastopathy, mastalgia, menopausal syndrome, 7-hydroxymatairesinol
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