Subject Of Interest Research Articles

Analysis of patient experiences regarding JAK inhibitors for atopic dermatitis, psoriasis, alopecia areata, and vitiligo.

The use of medications which target the JAK-STAT signaling pathway, also known as janus kinase (JAK) inhibitors, has rapidly increased in recent years. Patient perceptions, opinions, and concerns regarding the use of JAK inhibitors are largely uninvestigated. Our objective is to better understand patient concerns, reported side effects, and sentiments regarding the use of JAK inhibitors for dermatologic disease. The authors performed a cross-sectional analysis of the most frequented subreddits for dermatologic disease in which JAK inhibitors have obtained FDA approval (r/atopic dermatitis, r/psoriasis, r/alopecia areata, r/vitiligo, and r/eczeJAKS). The sentiment, central theme, and engagement level of each post was evaluated using previously utilized methods. Nine hundred twenty-three posts were analyzed, with the majority focusing on efficacy (433, 47%) and medication-related side effects (150, 16%). Other themes of interest to patients were Payment/Insurance (84, 9%), Study Results/News (69, 7%), Administration/Dosage (33, 4%), and Medication Interactions (31, 3%). The most frequently reported side effects were acne/folliculitis (24, 22%), nausea/gastrointestinal disturbance (11,10%), and fatigue/muscle aches (10, 9%). At the same time, the medication interactions garnering the most concern were sunscreens/facial moisturizers (5, 16%), topical calcineurin inhibitors (4, 13%), and Marijuana/THC (3, 9.%). This analysis highlights that patients are most concerned about the efficacy and side effects of JAK inhibitors in addition to issues regarding access to JAK inhibitors. Providers can use the insights gained from this study to address hesitancy better and guide comprehensive, patient-centered discussions with patients regarding JAK inhibitor use.

Special Issue of the Asian Journal of Business Ethics on Global Survey of Business Ethics (GSBE) Reports 2022–2024 from Asia, Australia, and Russia: Australia

AbstractThis report examines a study focused on current interest areas and themes of business ethics in Australia as discussed in the Australian media (major national and State newspapers) across the years 2019–2022, using content analysis and stakeholder frame of focus. The identified themes are then compared with themes identified in the Global Survey of Business Ethics 2022–2024. These themes provide a framework to compare with themes identified as important for teaching and research through a survey of Australian university educators in business schools involved in ethics teaching and research in South Australia and Western Australia. Findings indicate that ethics and ethical concerns appear across a range of media publications in Australia which in turn is placing pressure on businesses to respond to this ethics talk in the media in explaining or justifying their actions. Although no particular pattern is identified from responses, some topics are gaining more prominence such as climate change and artificial intelligence, both in the media and in university courses and research. Topics of discussion were ranked from very important to important. It is concluded that ethical issues are important for Australian business and business is responding. Key ethical issues include climate change and sustainability, governance, government and transparency, and organizational culture with ethical issues of interest to Australia featuring including sport, corporate misconduct, and Indigenous issues.

Nanomaterials in Brain Cancer Management with Special Emphasis on Personalized Therapy

Nanomaterials engineered for drug delivery penetrate the blood-brain barrier, ensuring direct access to cancerous cells, including carbon nanodots, liposomes, dendrimers, metallic nanoparticles, etc. By encapsulating therapeutic agents, nanomaterials enhance their stability and bioavailability, optimizing treatment efficacy. Furthermore, they enable real-time monitoring of treatment response, facilitating adjustments as needed. This strategy represents a significant advancement in oncology, offering a promising avenue for improving outcomes in brain cancer patients by maximizing therapeutic benefits while minimizing adverse effects. The discovery and development of novel nanomaterials and drug delivery systems based on nanotechnology are thus interesting topics for researchers working on the delivery of drugs to the brain and central nervous system. However, several challenges may be encountered in the development of nanomaterials and the commercialization of products. Further, the therapeutic outcomes may vary between patients. Thus, personalized therapy design for the delivery of nanomedicine may be a better option. The integration of personalized nanoparticle-based therapies holds great potential for transforming the landscape of brain cancer management, heralding a new era. Personalized therapy utilizing nanomaterials is revolutionizing brain cancer treatment by targeting tumours with precision while minimizing systemic toxicity. This approach tailors therapeutic interventions to individual patient profiles, accounting for tumor heterogeneity and patient-specific responses.

Pesan Dakwah Melalui Akun Tiktok Dalam Melestarikan Nilai Islami Pada Gen Z

Da'wah is very important to create a harmonious, peaceful, and of course in accordance with Islamic teachings. Da'wah messages and means are important components of the da'wah process. All materials derived from the Qur'an and Al-Hadith, which serve as the main source and guide of Islamic religious teachings, are included in the da'wah message. Young preachers among teenagers make innovations by preaching through the TikTok application and as a target is Generation Z by presenting interesting da'wah themes related to the problems faced by teenagers. There are several problems that can be formulated from the explanation of how the message of da'wah aqidah, morals, and shari'ah is. This study conducts descriptive research with a qualitative approach. The purpose of the descriptive qualitative approach is to describe the video content on the tiktok accounts of young preachers. With the characteristics and traits of generation z that are more open to differences and more accepting of diversity, making generation.

Educational Research Methodology Trends of Southeast Asia English Major Undergraduate Theses: A Content Analysis

The present study thoroughly examines the predominant research methodology trends and topics applied in a specific time frame from 2019 to 2023 in educational research of the online searchable undergraduate theses in English major programs across Southeast Asia, utilizing a comprehensive content analysis approach. By employing keyword extraction, topic-specific modelling, and thematic evaluation, our objective is to ascertain the prevailing methodologies in English language teaching and the research interest themes from 347 undergraduate downloadable theses that have been investigated. The analysis explores the possible ramifications of these patterns on the caliber of undergraduate research, English language instruction, and the broader education domain within the given area. This study revealed a strong preference (54.5%) for quantitative approaches, highlighting the importance of empirical methodologies. Additionally common were qualitative approaches (24.8%), suggesting an increasing recognition of the importance of examining human factors. While action research (8.4%), particularly Classroom Action Research (CAR), was less prevalent than mixed-method approaches (12.8%), this suggests that action research needs to be recognized. The different ratios of research methods demonstrated a dedication to investigating various questions and advancing knowledge in language, literature, and education. The interesting research themes identified the complex and diverse nature of English language raising focus in Southeast Asia such as technological integration, teacher development, cultural studies, assessment, and language teaching methodologies. The study provides useful information for enhancing research mentorship and education, and it improves knowledge of research trends in this setting. Furthermore, the findings obtained from this study have the potential to contribute to the enhancement of curriculum design, instructional approaches, and distribution of resources in the English language education research area.

Building Relationships, Forming Collaborations: Lessons Learned From an Unconference Seeking to Cultivate Solutions in Healthcare.

Calls for a 'major rethinking' of the delivery of healthcare services are echoed across Canada as the healthcare crisis continues. Proposed strategies to address the challenges of this crisis include: a transdisciplinary approach that is patient-focused and community-based; a representative team composed of patients, caregivers, healthcare providers, decision makers and policymakers; and authentic collaboration among stakeholder groups throughout the research cycle. This study aimed to enable community members to take on a leading role in building capacity and to provide a space for discourse among diverse groups while respecting community wisdom, values and priorities. The Collaborative Health Research Institute of Southern Alberta (CHRISA) organized a participant-oriented Unconference event to address the factors contributing to the healthcare crisis in Alberta, Canada. An Unconference is a participant-oriented meeting where the attendees nominate the topics, agree on the agenda and lead the sessions. This article describes the Unconference programme and presents the findings from a thematic analysis of the discussion notes from breakout sessions, feedback from participants (i.e., lessons learned) and pragmatic recommendations for future Unconference events. Findings from sessions included the following: (1) identifying the 'wicked' problems, (2) the factors/causes contributing to each problem (i.e., contributors) and (3) potential multifaceted solutions or ideas to remedy the problem. Lessons learned from the postevent evaluation resulted in six recommendations for organizing future Unconferences. The CHRISA Unconference achieved its goals by providing a venue for attendees to connect, engage and network on topics of interest, explore new ways of addressing challenges in healthcare and serve as a foundation for future initiatives and collaborations in healthcare research and practice. The Unconference was attended by community members who identify as patients, frontline workers, programme administrators and representatives of public organizations and agencies. Participants contributed to breakout session discussions, provided feedback on the Unconference and offered recommendations for future events. The co-authors are service users, people with lived experience or those work in the healthcare setting; they have been involved in data collection, analysis and interpretation, and contributed to this report.

Incentive Impact on Data Quality, Sample Composition, and Respondents’ Topic Interest

This article investigates the impact of offering a small incentive for a web survey of utility customers in the Mid-Atlantic United States. We explore background demographics and characteristics, response patterns, and data quality. Offering a small incentive was found to increase response rates. We did not find convincing evidence that offering an incentive affects data quality. However, we did find some evidence that the lack (or presence) of an incentive may impact sample composition and failing to provide an incentive may lead to more responses from people who are more interested in the survey topic.

A Practical Guide to Using Oral JAK Inhibitors for Atopic Dermatitis from the International Eczema Council.

Janus kinase inhibitors (JAKinibs) have the potential to dramatically alter the landscape of atopic dermatitis (AD) management due to their promising efficacy results from phase 3 trials and rapid onset of action. However, JAKinibs are not without risk, and their use is not appropriate for all AD patients, making this a medication class that dermatologists should understand and consider when treating patients with moderate-to-severe AD. This consensus expert opinion statement from the International Eczema Council (IEC) provides a pragmatic approach to prescribing JAKinibs, including choosing appropriate patients, dosing, clinical and lab monitoring, as well as long-term use. An international cohort of authors from the IEC with expertise in JAKinibs selected topics of interest and were formed into authorship groups covering 10 subsections. The groups performed topic-specific literature reviews, consulted up-to-date adverse event (AE) data, referred to product labels and provided analysis and expert opinion. The manuscript guidance and recommendations were reviewed by all authors as well as the IEC Research Committee. We recommend JAKinibs be considered for patients with moderate to severe AD seeking the benefits of rapid reduction in disease burden and itch, oral administration, and the potential for flexible dosing. Baseline risk factors should be assessed prior to prescribing JAKinibs, including increasing age, venous thromboembolisms, malignancy, cardiovascular health, kidney/liver function, pregnancy and lactation, and immunocompetence. Patients being considered for JAKinib therapy should be current on vaccinations and we provide a generalized framework for laboratory monitoring, though clinicians should consult individual product labels for recommendations as there are variations among the JAKinib class. Patients who achieve disease control should be maintained on the lowest possible dose, as many of the observed AEs occurred in a dose-dependent manner. Future studies are needed in AD patients to assess the durability and safety of continuous long-term use of JAKinibs, combination medication regimens, and the effects of flexible, episodic treatment over time. The decision to initiate a JAKinib should be shared among patient and provider, accounting for AD severity and personal risk/benefit assessment, including consideration of baseline health risk factors, monitoring requirements and treatment costs.

Attentional mediators of the effect of interest on comprehension

BackgroundWhile text reading is still a preferred form of learning, topic interest can be considered an important predictor of reading comprehension. However, the nature of the relationship between interest and comprehension is not yet fully understood. AimsThe present study investigates whether topic interest is related to comprehension when measured in advance and whether two indicators of attention (i.e., mind wandering and cognitive coupling) mediate this relation. SampleParticipants were 238 university students. MethodsParticipants rated their interest in three different topics. One week later, they read one text on each of these topics. The texts’ levels of difficulty were manipulated to change during reading. Measured variables during reading were the individual adaptation of the reading speed to the text difficulty (cognitive coupling) and the frequency of mind wandering. In addition, comprehension was measured after reading each text. ResultsPreliminary assessed topic interest was found to be indirectly but not directly associated with reading comprehension. Specifically, topic interest negatively predicted mind wandering during reading, while mind wandering was, in turn, negatively associated with reading comprehension. In addition, partial evidence was found for the mediating role of cognitive coupling. ConclusionsThe present study adds to the research by showing that topic interest can predict future mind wandering and one type of cognitive coupling. Because mind wandering was, in turn, negatively related to reading comprehension, the study's findings further suggest that topic interest should be encouraged to minimize harmful mind wandering, promote adaption to text properties, and thus improve comprehension.

Artificial intelligence, machine learning and GIS in environmental engineering: current trends

The use of computational tools, such as Artificial Intelligence, Machine Learning or Geographic Information Systems, has had a significant impact on the knowledge generated on environmental issues in recent years. The number of publications shown in this preliminary review of the IEEE Xplore Digital Library database shows its broad applicability and scientific relevance. Search filters and keywords such as water, air, soil, climate change, energy and waste were used. The data obtained was processed to visualize the proportion of use in key topics of environmental interest, giving scientific guidance towards the sites of greatest applicability, as well as towards areas that deserve to be reinforced. In this way, this work aims to promote the development of collaborative work solutions in the related areas of environmental and computational engineering.

Personalized Neuroimaging Reveals the Impact of Children's Interests on Language Processing in the Brain.

Cognition is shaped by individual experiences and interests. However, to study cognition in the brain, researchers typically use generic stimuli that are the same across all individuals. Language, in particular, is animated and motivated by several highly personal factors that are typically not accounted for in neuroimaging study designs, such as "interest" in a topic. Due to its inherently personal and idiosyncratic nature, it is unknown how interest in a topic modulates language processing in the brain. We conducted functional magnetic resonance imaging (fMRI) in 20 children (ages 6.98-12.01 years, mean(SD)=9.35(1.52), 5 female/15 male) as they listened to personalized narratives about a topic of specific interest, as well as to non-personalized generic narratives. We found that personalized narratives about a topic of interest increased activation in canonical language areas, as well as in reward and self-reference regions. Strikingly, we found that activation patterns elicited by topics of personal interest were more consistent across children, despite their idiosyncratic nature, than activation patterns elicited by narratives about an identical generic topic. These results reinforce the critical role that personal interests play in language processing in the human brain, and demonstrate the feasibility of using a personalized neuroimaging approach to study the effects of individually-varying factors such as interest in the brain.

The Study of Pilgrimage in Tibetan Buddhism: Overview and Recommendations for Instructors

ABSTRACTThroughout the history of Tibet, sacred places such as mountains, lakes, caves, and monasteries have been visited by laypeople and religious elites alike in search of purification, blessings, karma, long life, teachings, and spiritual transformation. More recently, scholars have studied the history and evolving present circumstances of pilgrimages across the Tibetan landscape. While the study of pilgrimage in Tibet remains a relatively small subfield, in the past 30 years, this body of scholarship has grown. This article will provide a short overview of this scholarship on pilgrimage in Tibetan Buddhism. It is intended as an introduction to people new to the field of pilgrimage studies in Tibet, so that they can orient themselves in the literature, find resources on topics of interest, or find teaching resources.

Developing the Society of Obstetric Medicine Australia and New Zealand (SOMANZ) Hypertension in Pregnancy Guideline 2023: Guideline development approaches, challenges and contextual considerations

AbstractThe Society of Obstetric Medicine Australia and New Zealand (SOMANZ) Hypertension in Pregnancy Guideline 2023 is the first evidence‐based guideline for hypertensive disorders of pregnancy that has been developed to the standards of the Australian National Health and Medical Research Council (NHMRC). This article describes the methodology, challenges and considerations in developing the guideline and includes details on group composition, literature search, evidence synthesis and development of recommendations. We also discuss several practical considerations and challenges related to contextual issues, topics of interest and resources available for guideline developers working with similar jurisdictions or topics.

Irrational Outputs from Rational Inputs in Theta-3 Functions Using Dirichlet’s Theorem

Theta Functions are not an easy subject of mathematics because new researches about this wide topic are still being published regularly. The findings about Theta Functions lead directly to many applications in different fields of applied mathematics and help also to develop old interesting mathematical topics such as Poisson summation and Riemann Zeta Function. This work proves by using a theorem of Dirichlet and a previously demonstrated useful approximation that the rational inputs of Theta-3 Functions give only irrationals as outputs of these functions. This paper applies only simple notions of sequences and represents an opportunity for the students of mathematics to easily understand the steps of the demonstrations.

Integrating emergency preparedness competency frameworks in workforce development training

BackgroundPublic health and emergency workforce development have been major topics of interest during and after the COVID-19 pandemic. The fragile state of many healthcare systems worldwide during emerging outbreaks revealed the need for regular competency-based training. The training helps to equip and remind health professionals how to tackle huge obstacles that need to be handled in emergencies. ObjectiveThis paper will examine an emergency preparedness training course we have developed and delivered multiple times. The course involved development, delivery, case scenario training, participant assessment, and a programme evaluation. Study DesignA descriptive study based on the ten essential public health functions, with the competencies for each function examined. ResultsThe evaluation showed that the curriculum was well-received, and 55 % of the participants could apply what they learned through a survey. Furthermore, the evaluation indicated a need to hold this training course frequently. Designing such courses could fill the gaps that emerged during life-threatening previous outbreaks. All participants passed the assessment with a minimal score of 63 % and the highest score of 93 %. ConclusionThe curriculum's design based on competencies needed for planning and preparedness for effective response to emergencies was well received and proved practical. Regular reminders of the tools needed, and their application are crucial. Learning and practising are critically important to tackling disasters, including mass gatherings.

Erotic countermapping and queer urban publics: the hardcore cinema of Arthur J. Bressan, Jr

ABSTRACT This article offers an analysis of hardcore films by Arthur J. Bressan, Jr, whose status as a pioneer of HIV/AIDS cinema has overshadowed his prolific work as a director of gay pornography. By focusing on the urban landscape of San Francisco as central to the dramaturgy of his early pornographic films, the article considers the documentary impulse evident in Bressan’s representation of urban queer topographies as inseparable from the films’ erotic charge. The article puts critical pressure on representations of cruising, the closet of sexual secrecy, and the prison as a site of sexual fantasy as erotic and spatial tropes central to Bressan’s queer countermapping of San Francisco. The urban landscape and its infrastructures are analyzed as central to Bressan’s cinematic mediation of San Francisco, and are reframed in this article as the scaffolding for the films’ thematic interest in queer pedagogy, gay visibility, and sexual liberation.

Survey of Multiple Destination Route Discovery Protocols

Route discovery protocols for multiple destination is one of the most interesting research topics since it is applied for real-world applications and needed in smart cities services such as: delivery services. The inclusion of artificial intelligence can improve the performance of multiple destination route discovery protocols. In this paper, we studied and analyzed multiple destination route discovery protocols based on different search strategies especially artificial intelligent methods. The survey compares between multiple destination route discovery protocols relate to its applications and implementation tools.

Analysis of the topic type and interest of YouTube content of public sports institutions : Focusing on the YouTube channel of the Korean sport and olympic committee

Analysis of the topic type and interest of YouTube content of public sports institutions : Focusing on the YouTube channel of the Korean sport and olympic committee

Two models for wave propagation in polymer/halloysite nanotube nanocomposites: network phenomena/generalized continuum mechanics

In the modeling of polymer/halloysite nanotube nanocomposites, it is essential to include the influences of halloysite nanotube/interphase network because this type of reinforcement creates networks after percolation onset. Besides, it has been proven by experimental tests and theoretical simulations that classical continuum theories are unable to study some nano-sized problems. In the present paper, considering the above facts, new research is done on wave propagation in the polymer/halloysite nanotube nanocomposites while considering the halloysite nanotube/interphase network and generalized continuum mechanics instead of classical continuum theories. In this article, two different models are used to study the effects of halloysite nanotube/interphase network and the length scale parameters on wave behaviors. The results for several different cases are compared and validated with experimental and theoretical results. As far as the authors of the present article know, this is the first time that the combination of these two interesting topics is studied, which can have its points.

Women are under-represented in adaptation policy research and are more likely to emphasise justice topics

Abstract This paper is the first to analyse the role of women authors in fostering justice-relevant topics in climate adaptation research. As representation, citation and payment patterns remain gender-biased across scientific disciplines, we explore the case of climate science, particularly adaptation, as its most human-oriented facet. In climate research and policy, there has been a recent surge of interest in climate justice topics: mentions of justice have increased almost tenfold in IPCC Working Group 2 reports between the latest assessment cycles (AR5 and AR6). We conduct a systematic examination of the topic space in the adaptation policy scholarship. As it is a vast and rapidly growing field, we use topic modelling, an unsupervised machine learning method, to identify the literature on climate justice and related fields, as well as to examine the relationship between topic prevalence and the gender of the authors. We find climate change adaptation policy research to be male dominated, with women holding 38.8% of first and 28.8% of last authorships. However, we observe topic-specific variability, whereby the share of female authors is higher among publications on justice-relevant topics. Female authorship is highly linked to topics such as Community, Local Knowledge, and Governance, but less to Food Security and Climate Finance. Our findings corroborate the evidence that female authors play a significant role in advancing the research and dialogue on the relationship between climate change and areas that have meaningful impact on lives of women and other marginalised groups.