Topic Citation Research Articles

Mapping sexual orientation research in management: A review and research agenda

AbstractAttitudes, norms, and laws regarding sexual orientation are undergoing a worldwide revolution. Managers and HR professionals play a key role in responding to these changes, and managing issues related to sexual orientation diversity in organizations. As such, the amount of management scholarship on sexual orientation has been rapidly growing to help inform practice. However, at present, the literature is fragmented across management specialty areas. This makes it difficult to have an overview of what has been learned to date, and detect research opportunities. Thus, this article aims to provide the first integrative review of sexual orientation research across the management field over 23 years. We use bibliometric techniques to (a) systematically identify and map 111 topics in this literature (map downloads from:https://bit.ly/SOTopicMap), (b) identify topic trends and topic citation rates, and (c) derive an inductive taxonomy of major topic clusters. We then identify key theories and relationships in the literature, review key findings for scholars and practitioners, and identify future research directions. Among these, we highlight the need to incorporate sexual orientation as a standard demographic question in management research, and highlight best practices for doing so from other scientific fields.

Deep Learning Research Trends Analysis with Ego Centered Topic Citation Analysis

Deep Learning Research Trends Analysis with Ego Centered Topic Citation Analysis

Journal topic citation potential and between-field comparisons: The topic normalized impact factor

Abstract The journal impact factor is not comparable among fields of science and social science because of systematic differences in publication and citation behavior across disciplines. In this work, a source normalization of the journal impact factor is proposed. We use the aggregate impact factor of the citing journals as a measure of the citation potential in the journal topic, and we employ this citation potential in the normalization of the journal impact factor to make it comparable between scientific fields. An empirical application comparing some impact indicators with our topic normalized impact factor in a set of 224 journals from four different fields shows that our normalization, using the citation potential in the journal topic, reduces the between-group variance with respect to the within-group variance in a higher proportion than the rest of indicators analyzed. The effect of journal self-citations over the normalization process is also studied.

폭소노미 연구 문헌에 대한 자아 중심 주제 인용 분석

이 연구에서는 White가 제안한 자아 중심 인용 분석을 응용하여 연구 주제에 대한 다층적인 분석을 가능하게 해주는 자아 중심 주제 인용 분석 기법을 제안하였다. 시험적으로 폭소노미에 대한 연구문헌을 Web of Science 데이터베이스로부터 검색한 후 이에 대한 주제 인용 분석을 수행해보았다. 폭소노미 주제에 대한 자아 중심 인용 분석은 자아 문헌 집단 분석, 주제 인용 정체성 분석, 주제 인용 이미지 분석의 세 단계로 나뉘어 수행되었다. 분석 결과 이 연구에서 제안된 자아 중심 주제 인용 분석을 통해서 폭소노미 연구의 내부 지적 구조와 외부 지적 구조를 함께 파악하는 것이 가능함이 확인되었다.

Differential Default Mode Network Response to Rest Cues in Adults with Attention Deficit Hyperactivity Disorder

Differential Default Mode Network Response to Rest Cues in Adults with Attention Deficit Hyperactivity Disorder

“Classifying memory traces in Judgments of Learning using Support-Vector Machines”

Event Abstract Back to Event “Classifying memory traces in Judgments of Learning using Support-Vector Machines” Luciana Falbo1* and Peter Stiers1 1 Maastricht University, Neuropsychology and psychopharmacology, Netherlands Behavioural studies have demonstrated that monitoring the study process helps scholars regulate learning more efficiently. The mechanisms of monitoring one’s own knowledge are still under debate. It has been suggested that memory processes are involved, but only indirect proofs exist. The purpose of the present study is to provide supporting evidence of a key role of memory when students make Judgments of Learning (JOL), by looking at the underlying neural mechanisms with fMRI. We verified the hypothesis that immediate JOL are based on working memory networks, while delayed JOL involve long-term memory processes. A slow event-related design of a word pair paradigm was used to investigate brain activity of 5 healthy subjects during JOL and retrieval, both occurring at different time lags from encoding (8 seconds, 100 seconds, 24 hours). Multivariate pattern analyses, which have shown to be more sensitive at capturing distributed patterns of activity simultaneously measured, were used to classify BOLD signal of JOL and memory in each individual data set. Different classifiers were used and they successfully attributed immediate JOL to working memory, and delayed JOL to long-term memory with accuracies ranging from 85 to 90%. Our findings indicate that memory is a fundamental cue during JOL. Keywords: Memory, Judgments of Learning, fMRI, multivariate analysis, Learning Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Falbo L and Stiers P (2012). “Classifying memory traces in Judgments of Learning using Support-Vector Machines”. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00022 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Miss. Luciana Falbo, Maastricht University, Neuropsychology and psychopharmacology, Maastricht, Netherlands, luciana.falbo@maastrichtuniversity.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Luciana Falbo Peter Stiers Google Luciana Falbo Peter Stiers Google Scholar Luciana Falbo Peter Stiers PubMed Luciana Falbo Peter Stiers Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Spatial extent of the local field potential in macaque area LIP

Event Abstract Back to Event Spatial extent of the local field potential in macaque area LIP Elsie Premereur1 and Peter Janssen1* 1 KULeuven, Belgium The spatial extent of gamma oscillations in the local field potential (LFP) is heavily debated at present. To address this issue we recorded multi-unit activity (MUA) and LFPs in the Lateral Intraparietal area (LIP) with a multi-electrode probe with 16 contact points spaced 150 microns apart (total distance covered: 2.25 mm). The recording cylinder was positioned in an oblique angel to allow recordings orthogonal to the lateral bank of the intraparietal sulcus. We positioned the probe so that all electrodes were located in the cortex of the lateral bank. Spike rate and LFP-activity were recorded while the monkey was performing a memory guided saccade task towards ten different positions in the contralateral visual field. We recorded activity in 14 grid positions, during 40 recording sessions. We found that only the MUA and high-gamma (80-170 Hz) power were significantly affected by target position. Furthermore, for every recording session, we determined the electrode which showed the highest visual spike rate response across target positions (0-320 ms after target onset), which we termed the primary electrode. We then calculated the MUA and LFP responses for this condition on neighboring electrodes and determined the distance from the primary electrode where the response fell below 50% of the response at the primary electrode. Consistent with previous studies we found that the visual MUA response was highly localized within 200 micron around the primary electrode: the MUA response fell below 50% of the primary electrode response at an average distance of 213 micron. The high-gamma response was also significantly affected by distance from the primary electrode but fell to 50% of the primary electrode response at an average distance of 1650 micron (where no MUA response was present), indicating that even the high-gamma oscillations are shared over a much larger distance across the cortical thickness. The medium gamma (50-80 Hz), low gamma (25-50 Hz), beta (12-25 Hz) and alpha (8-12 Hz) power never fell below 50% of the primary electrode response along the probe shaft. These results show that target-selective MUA responses in area LIP are highly localized, whereas LFP-responses, even in the high, medium and low gamma band, extend over a much larger region of cortex, sometimes even across the entire cortical thickness. Acknowledgements ERC-StG 260607, FWO, GOA, PFV, IUAP Keywords: multielectrode arrays, Macaca mulatta, Lateral Intraprietal Area (LIP), Saccades, local field potential (LFP) Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Premereur E and Janssen P (2012). Spatial extent of the local field potential in macaque area LIP. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00072 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Aug 2012; Published Online: 12 Sep 2012. * Correspondence: Prof. Peter Janssen, KULeuven, Leuven, Belgium, Peter.Janssen@med.kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elsie Premereur Peter Janssen Google Elsie Premereur Peter Janssen Google Scholar Elsie Premereur Peter Janssen PubMed Elsie Premereur Peter Janssen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Functional and Effective Connectivity in Healthy Human EEG across Sleep Stages.

Functional and Effective Connectivity in Healthy Human EEG across Sleep Stages.

Modulation of cortex–muscle coherence by observation of another person’s hand movements

Event Abstract Back to Event Modulation of cortex–muscle coherence by observation of another person’s hand movements Mathieu Bourguignon1, 2*, Harri Piitulainen2, Eero Smeds2, Xavier De Tiège1, Veikko Jousmäki2 and Riitta Hari2 1 Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Belgium 2 Brain Research Unit, O.V. Lounasmaa Laboratory, School of Science, Aalto University, Finland During steady contraction of hand muscles, ~20-Hz oscillations of the contralateral primary motor cortex (M1) are coherent with surface electromyogram (EMG). This cortex–muscle coherence (CMC) likely reflects population-level modulation of the motoneuron pool. Here we used CMC as an index of the motor-cortex state during observation of another person’s movements. We recorded CMC between cortical signals, measured with 306-channel MEG (Elekta Oy, Finland) and the right first dorsal interosseous EMG from 14 healthy subjects who viewed an experimenter performing transient index–thumb flexions against a load cell once every 3–6 s; the experimenter was sitting 2 m in front of the subject, only his hand visible. Measurements were carried out at the MEG Core of the Aalto University, Finland. CMC was first evaluated over the whole experiment to identify the gradiometer displaying the strongest coherence in the 10–30 Hz range. Five subjects lacking significant coherence were removed from the further analysis, and thus results are based on the data of 9 subjects (mean age 29 yrs, range 22–35; 4 f, 5 m). Time–frequency power and coherence maps from –3000 to 3000 ms time-locked to experimenter’s movement onsets were computed for the selected gradiometer and averaged across subjects. The group-level coherence map revealed a significant coherence increase at ~18 Hz about 500 ms after the movement onset; ~7-Hz and ~15-Hz signals were suppressed around 400 ms. The viewer’s M1 cortex is activated during action observation, as is evident from the suppression of the rolandic 20-Hz rhythm. Nevertheless a healthy viewer does not automatically imitate the seen action. The current findings of increased CMC following the observed action can be interpreted to indicate improved stabilization of the motor-cortex output, thereby contributing to the prevention of automatic imitation. Keywords: corticomuscular coherence, action observation, Magnetoencephalography, Electromyography, brain rhythms Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Bourguignon M, Piitulainen H, Smeds E, De Tiège X, Jousmäki V and Hari R (2012). Modulation of cortex–muscle coherence by observation of another person’s hand movements. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00017 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Mr. Mathieu Bourguignon, Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Brussel, Belgium, mabourgu@ulb.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mathieu Bourguignon Harri Piitulainen Eero Smeds Xavier De Tiège Veikko Jousmäki Riitta Hari Google Mathieu Bourguignon Harri Piitulainen Eero Smeds Xavier De Tiège Veikko Jousmäki Riitta Hari Google Scholar Mathieu Bourguignon Harri Piitulainen Eero Smeds Xavier De Tiège Veikko Jousmäki Riitta Hari PubMed Mathieu Bourguignon Harri Piitulainen Eero Smeds Xavier De Tiège Veikko Jousmäki Riitta Hari Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Event Abstract Back to Event On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination Kamila Skieterska1*, Pieter Rondou1, Dasiel O. Borroto-Escuela2, Dorien Clarisse1, Béatrice Lintermans1, Guy Haegeman1, Kjell Fuxe2 and Kathleen Van Craenenbroeck1 1 Ghent University, Physiology, Belgium 2 Karolinska Institutet, Neuroscience, Sweden The dopamine D4 receptor belongs to the superfamily of G protein-coupled receptors (GPCRs), the most common drug targets. The dopamine D4 gene displays a remarkable polymorphisms that differ in a variable number of tandem repeats in the region encoding the third intracellular loop. The most frequent variants in the human population are respectively: the 4-repeat allele (D4.4R), 7-repeat allele (D4.7R) and 2-repeat allele (D4.2R), of which the D4.7R polymorphic variant is associated with a predisposition to develop Attention Deficit Hyperactivity Disorder (ADHD). The functional role of the receptor polymorphic region is still poorly understood. We have identified a BTB-Kelch protein, KLHL12, which specifically interacts with the polymorphic repeats and enhances ubiquitination of the D4R. Interestingly, however, we have found that KLHL12 only marginally affects ubiquitination of the D4.7R variant, in contrast to strong induction of ubiquitination of the D4.2R and D4.4R variants. This suggests that differential ubiquitination of the D4R has functional implications. Most studies have focused on the role of GPCR ubiquitination in receptor degradation; nevertheless, our experimental results gave clear evidence that KLHL12-mediated D4R ubiquitination does not lead to receptor degradation. Moreover, our preliminary data suggest that KLHL12 might mediate a non-lysine ubiquitination of the receptor which is currently studied more profoundly. Furthermore, we are investigating the influence of ubiquitination on receptor signaling and found a role in modulation of cAMP level upon D4R activation. Acknowledgements This work was financially supported by FWO (Fonds voor Wetenschappelijk Onderzoek) Vlaanderen: project No. G.0109.09N. K. Skieterska is a recipient of a pre-doctoral FWO fellowship. K. Van Craenenbroeck has a post-doctoral FWO fellowship. Keywords: dopamine D4 receptor, Ubiquitination, KLHL12, ADHD, GPCR Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Skieterska K, Rondou P, Borroto-Escuela DO, Clarisse D, Lintermans B, Haegeman G, Fuxe K and Van Craenenbroeck K (2012). On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00053 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Ms. Kamila Skieterska, Ghent University, Physiology, Ghent, 9000, Belgium, kamila.skieterska@ugent.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kamila Skieterska Pieter Rondou Dasiel O Borroto-Escuela Dorien Clarisse Béatrice Lintermans Guy Haegeman Kjell Fuxe Kathleen Van Craenenbroeck Google Kamila Skieterska Pieter Rondou Dasiel O Borroto-Escuela Dorien Clarisse Béatrice Lintermans Guy Haegeman Kjell Fuxe Kathleen Van Craenenbroeck Google Scholar Kamila Skieterska Pieter Rondou Dasiel O Borroto-Escuela Dorien Clarisse Béatrice Lintermans Guy Haegeman Kjell Fuxe Kathleen Van Craenenbroeck PubMed Kamila Skieterska Pieter Rondou Dasiel O Borroto-Escuela Dorien Clarisse Béatrice Lintermans Guy Haegeman Kjell Fuxe Kathleen Van Craenenbroeck Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Can vision influence trigeminal nociception: A study of the effect of visual cortex activation on the nociceptive blink reflex in healthy subjects and migraine patients.

Can vision influence trigeminal nociception: A study of the effect of visual cortex activation on the nociceptive blink reflex in healthy subjects and migraine patients.

State dependent changes in resting electroencephalographic activity in children with and without Attention Deficit Hyperactivity Disorder

State dependent changes in resting electroencephalographic activity in children with and without Attention Deficit Hyperactivity Disorder

The minimum effective shape feature for neurons in the macaque Anterior Intraparietal area

Event Abstract Back to Event The minimum effective shape feature for neurons in the macaque Anterior Intraparietal area Maria C. Romero1* and Peter Janssen1* 1 KULeuven, Laboratory for Neuro- and Psychofysiology, Belgium Neurons in the Anterior Intraparietal area (AIP) respond selectively to two-dimensional shapes and contours (Romero et al., 2012). In the present study we investigated the minimum effective shape features evoking selective responses in AIP of two rhesus monkeys using a stimulus reduction approach. The stimulus set in this reduction test consisted of contour shapes derived from images of real-world objects (full outlines; circumference ~16 deg), and line segments obtained by subdividing the full contours into 4, 8 and 16 segments (length 4, 2 and 1 deg, respectively). We first mapped the receptive field (RF) of every responsive AIP neuron with effective (preferred) and non-effective (nonpreferred) images of real-world objects (size 3 deg) presented in a 12 by 8 deg area around the fixation point during passive fixation. All stimuli in the reduction test were presented on the RF center, at their corresponding position in the original image. Almost all AIP neurons tested (47/48) responded significantly to at least one of the 4, 8 or 16-fragment stimuli obtained by reduction. We considered that a shape fragment was effective for the neuron if the response rate to the fragment was at least 50 % of their maximum response in the test. With this criterion, 83% (40/48) of our AIP cells responded to at least one of the 4-fragment stimuli, 88% (42/48) responded to at least one of the 8-fragment stimuli, and 75% (36/48) responded to at least one of the 16- fragment stimuli. However, the number of effective fragments for each cell was on average low, as most neurons (41/ 48; 85 %) were only responsive for less than 6 fragments in the test. A large majority of cells (41/48; 88%) responding to fragments in the preferred shape were also responsive to fragments derived from the nonpreferred shape. The RF mapping revealed a cluttered RF profile in a high proportion of AIP cells (33/48; 69%), with several local maxima and minima. Furthermore, the RF profile depended heavily on the stimulus used, as measured by the low 2D correlation between responses to the best 3 deg surface and the best fragment (average r = 0.36). The remaining AIP cells (15/48; 31%) showed localized, foveal RFs. Overall, our results demonstrate that for most AIP neurons the minimum effective shape feature consists of very small line fragments measuring merely 1 deg. The RF structure in AIP can be highly complex and depending on the stimulus used. Acknowledgements Supported by ERC-StG-260607, PFV10 ⁄ 008, GOA 10 ⁄ 19, FWO (G.0713.09). References Romero M.C., Van Dromme I., Janssen P. (2012) Responses to two-dimensional shapes in the macaque anterior intraparietal area. European Journal of Neuroscience, 36: 2324-2334. Keywords: Visual Neuroscience, shape, Parietal Lobe, Electrophysiology, monkey Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Romero MC and Janssen P (2012). The minimum effective shape feature for neurons in the macaque Anterior Intraparietal area. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00109 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Aug 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Maria C Romero, KULeuven, Laboratory for Neuro- and Psychofysiology, Leuven, 3000, Belgium, Maria.C.Romero@med.kuleuven.be Prof. Peter Janssen, KULeuven, Laboratory for Neuro- and Psychofysiology, Leuven, 3000, Belgium, Peter.Janssen@med.kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Maria C Romero Peter Janssen Google Maria C Romero Peter Janssen Google Scholar Maria C Romero Peter Janssen PubMed Maria C Romero Peter Janssen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

CONSOLIDATION THROUGH THE LOOKING-GLASS: SLEEP-DEPENDENT PROACTIVE INTERFERENCE ON PROCEDURAL LEARNING IN CHILDREN

Event Abstract Back to Event CONSOLIDATION THROUGH THE LOOKING-GLASS: SLEEP-DEPENDENT PROACTIVE INTERFERENCE ON PROCEDURAL LEARNING IN CHILDREN Charline Urbain1, 2*, Emeline Houyoux1, Genevieve Albouy3 and Philippe Peigneux1 1 Université Libre de Bruxelles, UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles , Belgium 2 Université Libre de Bruxelles, LCFC - Laboratoire de Cartographie Fonctionnelle du Cerveau, Hôpital Érasme, Belgium 3 University of Montreal, Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Canada Although a beneficial role of post-training sleep for declarative memory has been consistently evidenced in children like in adults, available data suggest that procedural memory consolidation does not benefit from sleep in children. We surmised that despite a possible absence of sleep-dependent changes in performance in children, sleep-dependent plasticity processes involved in procedural memory consolidation might be expressed through differential interference effects on the learning of novel but related procedural material. To do so, thirty-two 10-12 years old children were trained to the rotation adaptation task then retested after either a sleep or a wake period on the same rotation applied at learning, thus assessing offline sleep-dependent changes in performance. We then presented at retest the opposite (unlearned) rotation to assess sleep-dependent modulations in proactive interference of the consolidated visuomotor memory trace against learning of the new rotation. Results show that children gradually improve performance over the learning session, showing effective adaptation to the imposed rotation. Notwithstanding, besides a conspicuous absence of sleep-dependent changes in performance for the learned rotations, the presentation of the opposite, unlearned deviation elicited significantly worse performance (i.e. higher interference effects) after post-training sleep than wakefulness in children. Considering that a definite feature of procedural memory and skill acquisition is the implementation of highly automatized motor behaviour, thus lacking flexibility, our results suggest a better integration and/or automation or motor adaptation skills after post-training sleep, eventually resulting in higher proactive interference effects on untrained material. Consequently, our results suggest that sleep contributes in the consolidation of a procedural adaptation memory in children. Acknowledgements CU is supported by a grant of the ULB-ARC project "Pathophysiology of Memory Consolidation Processes“ and the Fondation Vigneron. GA is supported by a Canadian Institutes of Health Research (CIHR) postdoctoral grant. Keywords: Children, visuomotor adaptation, procedural learning, interference, Sleep, memory consolidation Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Urbain C, Houyoux E, Albouy G and Peigneux P (2012). CONSOLIDATION THROUGH THE LOOKING-GLASS: SLEEP-DEPENDENT PROACTIVE INTERFERENCE ON PROCEDURAL LEARNING IN CHILDREN. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00019 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Charline Urbain, Université Libre de Bruxelles, UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles, Bruxelles, 1050, Belgium, curbain@ulb.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Charline Urbain Emeline Houyoux Genevieve Albouy Philippe Peigneux Google Charline Urbain Emeline Houyoux Genevieve Albouy Philippe Peigneux Google Scholar Charline Urbain Emeline Houyoux Genevieve Albouy Philippe Peigneux PubMed Charline Urbain Emeline Houyoux Genevieve Albouy Philippe Peigneux Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

IS CORTICAL EXCITABILITY IN RATS ALTERED AFTER 1H OF HIGH FREQUENCY, POISSON DISTRIBUTED CORTICAL STIMULATION?

Event Abstract Back to Event IS CORTICAL EXCITABILITY IN RATS ALTERED AFTER 1H OF HIGH FREQUENCY, POISSON DISTRIBUTED CORTICAL STIMULATION? Ine Buffel1*, Alfred Meurs1, Robrecht Raedt1, Veerle De Herdt1, Riem El Tahry1, Bregt Van Nieuwenhuyse1, Lies Mollet1, Wytse Wadman2, Kristl Vonck1 and Paul Boon1 1 University Ghent, Internal Diseases - Neurology, Belgium 2 University of Amsterdam, Neurobiology, Netherlands Aims Neurostimulation is a promising treatment for patients with refractory focal epilepsy who are not amenable to resective surgery. We have evaluated the effect of high-frequency cortical stimulation on cortical excitability in the motor cortex model (CSM). In the CSM, a ramp-shaped pulse train with increasing intensity is delivered to the motor cortex. The threshold intensity for eliciting forelimb clonus is determined through behavioural observation, and used as a measure for cortical excitability. Methods Seven male Wistar rats were implanted with epidural electrodes over the motor cortex (AP-1mm; ML±3mm). All rats underwent 1h of sham stimulation, cortical stimulation (Poisson pulse, 130Hz, PW100µs) with an intensity of 10µA, or cortical stimulation at 100µA below the baseline threshold intensity on alternating days. The threshold intensity needed to elicit forelimb clonus was determined before (mean of 4measurements at 20min intervals) and immediately, 1h, 2h and 24h after stimulation. Results Sham stimulation did not alter the threshold to forelimb clonus. Therapeutic stimulation with an intensity of 100µA lower than baseline threshold (mean intensity 205±22µA) significantly increased the threshold to forelimb clonus from 305±22µA (before) to 347±19 (immediately after), 339±23 (1h), 327±20 (2h) and 277±21µA (24h) after stimulation (p<0.001). When stimulated at 10µA, the threshold increased from 302±25µA to 319±15µA, 318±21µA, 319±18 µA, 321±32µA. Conclusion High-frequency, Poisson-distributed cortical stimulation during 1h decreases cortical excitability at high intensities. This effect lasted 1h. Further studies are needed to determine whether this type of stimulation can become an effective alternative treatment for patients with focal neocortical epilepsy who are not amenable to surgery. Keywords: cortical stimulation, cortical excitability, Epilepsy, Rats, Poisson-distributed stimulation Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Buffel I, Meurs A, Raedt R, De Herdt V, El Tahry R, Van Nieuwenhuyse B, Mollet L, Wadman W, Vonck K and Boon P (2012). IS CORTICAL EXCITABILITY IN RATS ALTERED AFTER 1H OF HIGH FREQUENCY, POISSON DISTRIBUTED CORTICAL STIMULATION?. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00078 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Mrs. Ine Buffel, University Ghent, Internal Diseases - Neurology, Ghent, 9000, Belgium, Ine.Buffel@UGent.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ine Buffel Alfred Meurs Robrecht Raedt Veerle De Herdt Riem El Tahry Bregt Van Nieuwenhuyse Lies Mollet Wytse Wadman Kristl Vonck Paul Boon Google Ine Buffel Alfred Meurs Robrecht Raedt Veerle De Herdt Riem El Tahry Bregt Van Nieuwenhuyse Lies Mollet Wytse Wadman Kristl Vonck Paul Boon Google Scholar Ine Buffel Alfred Meurs Robrecht Raedt Veerle De Herdt Riem El Tahry Bregt Van Nieuwenhuyse Lies Mollet Wytse Wadman Kristl Vonck Paul Boon PubMed Ine Buffel Alfred Meurs Robrecht Raedt Veerle De Herdt Riem El Tahry Bregt Van Nieuwenhuyse Lies Mollet Wytse Wadman Kristl Vonck Paul Boon Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

High-resolution macaque MRI at 3T using implanted multichannel array coils.

High-resolution macaque MRI at 3T using implanted multichannel array coils.

Right Temporal Regions Help to Rapidly Create New Semantic Representations about the Functions of Novel Objects in Children

Event Abstract Back to Event Right Temporal Regions Help to Rapidly Create New Semantic Representations about the Functions of Novel Objects in Children Charline Urbain1, 2*, Mathieu Bourguignon2, Marc Op De Beeck2, Rémy Schmitz1, Sophie Galer1, 2, Vincent Wens2, Brice Marty2, Xavier De Tiège2, Patrick Van Bogaert2 and Philippe Peigneux1 1 Université Libre de Bruxelles, UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, Belgium 2 Université Libre de Bruxelles, LCFC - Laboratoire de Cartographie Fonctionnelle du Cerveau, Hôpital Érasme, Belgium Learning the functional properties of objects is a core mechanism in the development of conceptual, cognitive and linguistic knowledge in children. The cerebral process underlying these learning mechanisms remains unclear in adults and unexplored in children. Here, we investigated the neurophysiological patterns underpinning the learning of semantic properties about novel objects functions in eleven 10-years old healthy children. Event-related fields (ERFs) were recorded using magnetoencephalography (MEG) during a picture-definition task. Two MEG sessions were administered, separated by a behavioral verbal learning session during which children learned short definitions about the “magical” function of 50 unknown non-objects. Additionally, 50 familiar real objects and 50 other unknown non-objects for which no functions were taught were presented at both MEG sessions. Behavioral results showed that children learned at least 75% of the 50 proposed definitions in less than one hour, emphasizing children's powerful ability to rapidly map new functional meanings to novel objects. ERFs were analyzed first in sensor then in source space. Results in sensor space disclosed a learning-dependent modulation of ERFs for learned non-objects developing 500-800 msec post-stimulus onset. Analyses in the source space windowed over this late temporal component of interest disclosed underlying activity in right parietal, bilateral orbito-frontal and right temporal regions. Altogether, our results suggest that learning-related evolution in late ERF components over those regions may support the challenging task of rapidly creating new semantic representations about the functionalities and usage of novel objects in children. Acknowledgements CU was supported by a special grant of the Université Libre de Bruxelles (Vigneron Foundation) and the ULB-ARC project "Pathophysiology of Memory Consolidation Processes". RS, XDT and SG are supported by FRS-FNRS. MB is supported by FRIA (FRS-FNRS). The authors thank Claudine Morsa for the drawing of the stimuli used in this study, Willy Bruyr for help in the digitalization of each object and Antoine Désir for help in building and matching non-words. Keywords: Learning, Semantic representations, Magnetoencephalography, Children, declarative memory Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Urbain C, Bourguignon M, Op De Beeck M, Schmitz R, Galer S, Wens V, Marty B, De Tiège X, Van Bogaert P and Peigneux P (2012). Right Temporal Regions Help to Rapidly Create New Semantic Representations about the Functions of Novel Objects in Children. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00013 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Charline Urbain, Université Libre de Bruxelles, UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, Bruxelles, Belgium, curbain@ulb.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Charline Urbain Mathieu Bourguignon Marc Op De Beeck Rémy Schmitz Sophie Galer Vincent Wens Brice Marty Xavier De Tiège Patrick Van Bogaert Philippe Peigneux Google Charline Urbain Mathieu Bourguignon Marc Op De Beeck Rémy Schmitz Sophie Galer Vincent Wens Brice Marty Xavier De Tiège Patrick Van Bogaert Philippe Peigneux Google Scholar Charline Urbain Mathieu Bourguignon Marc Op De Beeck Rémy Schmitz Sophie Galer Vincent Wens Brice Marty Xavier De Tiège Patrick Van Bogaert Philippe Peigneux PubMed Charline Urbain Mathieu Bourguignon Marc Op De Beeck Rémy Schmitz Sophie Galer Vincent Wens Brice Marty Xavier De Tiège Patrick Van Bogaert Philippe Peigneux Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy

A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy

New stimulation pattern for covert SSVEP-based brain-computer interface

New stimulation pattern for covert SSVEP-based brain-computer interface

Cognitive interference with the control of precision grip

Event Abstract Back to Event Cognitive interference with the control of precision grip Erwan Guillery1*, André Mouraux1 and Jean-Louis Thonnard1 1 Université Catholique de Louvain (UCL), Institut of Neuroscience (IoNS), Belgium Simultaneous execution of cognitive and sensorimotor tasks is critical in our daily life. The purpose of this study was to examine the requirement of high-level cognitive controls in precision grip, using a motor-cognitive dual-task paradigm. In the motor task, subjects were asked to grip, lift and hold an instrumented manipulandum. The cognitive task consisted in a complex visual search combined with counting. Eighteen healthy naïve subjects took part in the experiment, (9 men and 9 women; mean age: 26 ± 3). Subjects sat comfortably in a chair in front of a desk supporting the manipulandum and a computer screen. The experiment consisted in performing three tasks: a motor task (M), a motor task with a concomitant cognitive task (MC), and a measure of the finger static friction coefficient. The M task was a grip-lift movement. In the MC task, participants were asked to grip and lift the manipulandum while counting the number of pictures in which a chimney and/or a garage could be seen. The skin-apparatus coefficient of static friction was measured for each subject in each task before and after each bloc of 10 trials in a series of eight lift-and-drop maneuvers. Different temporal and dynamics parameters were used to compare the M & MC tasks. The preloading phase was significantly lengthened in the MC task (p=0.010). It was about 60 ms longer in MC condition. The loading and the transition phase were not modified by the cognitive task. The cross correlation function did not reveal any alteration of the coupling between GF and LF. In both conditions the cross correlation coefficients were higher than 0,90 and the absolute time shift were around 20 ms. The peak grip force exerted during the grip-lift movement was significantly increased by the cognitive task (p=0.007), with respectively 6.57N ± 0.83 and 7.18N ± 1.01 (mean ± standard deviation), for the M and the MC task. This significant increase of the grip force remained at lift off during the MC task (p=0.035) and during the static phase when subjects hold the manipulandum while performing the cognitive task (p=0.009. Given that the lift force magnitude was equal in both conditions and since the coefficient of friction remains stable (p>0.5) along the experiment, the ratio GF/LF and the safety margin were obviously increased in the MC task (p<0.05). Keywords: Precision Grip, interference, Cognition, Dual Task Performance, Behavioral Research Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Guillery E, Mouraux A and Thonnard J (2012). Cognitive interference with the control of precision grip. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00050 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 31 Aug 2012; Published Online: 12 Sep 2012. * Correspondence: Mr. Erwan Guillery, Université Catholique de Louvain (UCL), Institut of Neuroscience (IoNS), Woluwe-Saint-Lambert, Bruxelles, 1200, Belgium, erwgn@yahoo.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Erwan Guillery André Mouraux Jean-Louis Thonnard Google Erwan Guillery André Mouraux Jean-Louis Thonnard Google Scholar Erwan Guillery André Mouraux Jean-Louis Thonnard PubMed Erwan Guillery André Mouraux Jean-Louis Thonnard Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.