Abstract
A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy
Highlights
Over the last decade, deep brain stimulation (DBS) has emerged as a possible therapy for refractory epilepsy patients
Since 2001, 11 patients with refractory mesial temporal lobe (MTL) complex partial seizures with or without secondary generalisation underwent uni-or bilateral MTL DBS depending on seizure onset localisation as determined by invasive video-EEG monitoring
2) In 5/6 patients in whom unilateral DBS failed to decrease seizure frequency with >90% after 2.5 to 3 years, bilateral DBS was started resulting in improved seizure control in 3/5 patients (> 90% reduction or seizure free)
Summary
Deep brain stimulation (DBS) has emerged as a possible therapy for refractory epilepsy patients. Different intracerebral targets have been targeted, including remote network structures (e.g. the anterior thalamic nucleus, the centromedian thalamic nucleus, the subthalamic nucleus, the caudate nucleus and the cerebellum) and the ictal onset zone. The latter can be approached by either continuous or responsive stimulation. In this abstract we present our long-term results with continuous mesial temporal lobe (MTL) DBS for MTL epilepsy
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