On the Mekong Riverbank, clean water mapping is a commonly utilized tool for disaster risk reduction and public health promotion initiatives. The purpose of this research is to investigate the possibility of clean water mapping as a transnational catastrophe mitigation initiative. A comprehensive literature analysis will be conducted to identify existing research and data on clean water maps, disaster risk reduction, and transnational water governance on the Mekong riverbank. The semi-structured interviews reveal current challenges and opportunities associated with cleaning water mapping, disaster risk prevention, and water governance, such as technical and institutional barriers, the need for collaborative and transdisciplinary approaches, and the complexity of transboundary water governance. The qualitative data demonstrate the potential benefits of cleaning water for disaster mitigation efforts, such as identifying high-risk areas and developing early warning systems for water-related disasters, as well as having broader public health benefits beyond the context of disasters. With the proper plans and tactics in place, clean water can make a big contribution to the region's long-term growth and people's well-being.