The present work conducts a multifidelity aerodynamic design of a medium-range commercial aircraft wing featuring hybrid laminar flow control (HLFC) technology. The design was performed to investigate the capabilities of the HLFC, considering the entire design flight envelope, low-speed performance requirements, and various potential mission scenarios. A combination of medium-fidelity aerodynamic design tools for laminar flow control using MSES-COCO-LILO, CFD RANS for high-lift cases, the quasi-three-dimensional for database generations, and SUAVE for mission analysis were used to design and assess aircraft’s performance with the HLFC wing. Studies of the design objective demonstrated a conflict between friction and compressibility drag that strongly affects the design objective function and the wing performance at various off-design conditions. A strong dependence of HLFC on flight conditions was observed to indicate technology performance limitations and a tradeoff between airplane emissions, range, and costs. Finally, a comparison of medium- and low-fidelity performance results showed deviations in the design fuel burn of 4%, a minimum possible harmonic range difference of 3%, and direct operating costs of 2%. The outcome suggests the need for better compressibility and parasite drag models for early design stages to accurately model the HLFC technology without introducing complicated methods at the first sizing steps.